DNA Replication Gaps, Cancer and Disease

April 27-30, 2025 | Daejeon Convention Center, DaejeonKorea, Republic of
Scientific Organizers: Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung

  In Person
  On Demand

April 27-30, 2025 | Daejeon Convention Center, DaejeonKorea, Republic of
Scientific Organizers: Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung

Available Formats:   = In Person     = On Demand
Sunday, April 27, 2025
Registration
4:00–8:00 PM
 2nd Floor Lobby/Terrace
Welcome Mixer
6:00–8:00 PM
 2nd Floor Lobby/Terrace
Monday, April 28, 2025
Breakfast
7:30–8:30 AM
 Individual Hotel
Poster Setup
8:00–8:30 AM
 Room 202
Welcome and Keynote Address
8:30–9:30 AM
 Room 202
Poster Viewing
8:30–5:00 PM
 Room 202
Helle D. Ulrich, Institute of Molecular Biology
Mind the Gap: How Ubiquitylation Controls Postreplicative Gap Formation and Repair in Response to DNA Replication Stress
DNA Replication Gaps: Causes and Consequences
9:30–11:45 AM
 Room 202
Vincenzo Costanzo, IFOM
Causes and Consequences of DNA Replication Gaps
Alessandro Vindigni, Washington University
Factors Modulating Gap Formation and Repair
Aura Carreira, Centro de Biologia Molecular Severo Ochoa (CSIC-UAM)
Mediating Replication ssDNA Gap Prevention and Repair Through the Lenses of BRCA2
Catherine H. Freudenreich, Tufts University
Gap-Induced Fragility at DNA Structures Revealed in a Yeast Model
Short Talk(s) Chosen from Abstracts
Coffee Break
10:00–10:20 AM
 Foyer
Lunch
11:45–12:45 PM
 Room 202
Posters
12:30–2:30 PM
 Room 202
Workshop 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
 Room 202
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Foyer
Gaps, Cell Death and Immune Responses
5:00–7:00 PM
 Room 202
Sharon B. Cantor, University of Massachusetts Chan Medical School
How the Gap Model Redefines Chemotherapy Response
Roger Greenberg, University of Pennsylvania
Tolerance to Stress vs. Immune Induction
Vanesa M. Gottifredi, Fundación Instituto Leloir
Causes and Consequences of the Choice between Template Switching, Traslesion DNA Synthesis and Repriming
Short Talk(s) Chosen from Abstracts
On Own for Dinner
7:00–8:00 PM
Tuesday, April 29, 2025
Breakfast
7:30–8:30 AM
 Individual Hotel
Visualizing and Defining the Gap Architecture
8:30–11:30 AM
 Room 202
Maria Spies, University of Iowa
Structure Activity Relationships: Capturing Gap Binding Proteins in the Act with CryoEM
Katharina Schlacher, MD Anderson Cancer Center
Talk Title to be Announced
Nitika Taneja, Erasmus Medical Center
BRCA1 Mediated Chromatin Organization at Gaps and Forks
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
 Foyer
On Own for Lunch
11:30–5:00 PM
Poster Setup
11:30–1:00 PM
 Room 202
Poster Viewing
1:00–10:00 PM
 Room 202
Roundtable Discussion: Gender and Diversity Issues in Biomedical Research
2:15–3:15 PM
 Room 202
Career Roundtable
3:30–4:30 PM
 Room 202
Coffee Available
4:30–5:00 PM
 Foyer
Gap Suppression and Avoidance Pathways in Cancer
5:00–7:00 PM
 Room 202
Alberto Ciccia, Columbia University
Gap Suppression in BRCA1/2-Deficient Cells
Dale A. Ramsden, University of North Carolina
Pol Theta and the Response to Replication Stress
Dana Branzei, FIRC Institute of Molecular Oncology
Cohesion in Replication Stress Tolerance
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
 Room 202
Posters
7:30–10:00 PM
 Room 202
Wednesday, April 30, 2025
Breakfast
7:30–8:30 AM
 Individual Hotel
Gaps, R-Loops and Replication Stress
8:30–11:30 AM
 Room 202
Keith W. Caldecott, University of Sussex
DNA Nicks, BER and Cancer
Thanos D. Halazonetis, University of Geneva
DNA Replication Stress and Cancer
Karlene A. Cimprich, Stanford University
R-Loops in Cancer
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
 Foyer
On Own for Lunch
11:30–5:00 PM
Workshop 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Foyer
Drugs Modulating and Capitalizing on a Cancer Gap Vulnerability
5:00–6:45 PM
 Room 202
Alan D. D'Andrea, Dana-Farber Cancer Institute
Pol theta Inhibitors Capitalize on a Gap Vulnerability
Orlando Schärer, IBS Center for Genomic Integrity
Trabectedin - Targeting Tumors through Transcription-Coupled Nucleotide Excision Repair Induced DNA Gaps
Jill Bargonetti, Hunter College, City University of New York
Gain of Function Mutant p53, MDM2, and PARP1 Coordinate Responses for Cancer Persistent Repair at Gaps
Kyungjae Myung, Institute for Basic Science and UNIST
Translation of DNA Damage Including Gap for Cancer Therapy
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
 Room 202
Social Hour with Lite Bites
7:00–8:00 PM
 Room 202
Cash Bar
8:00–9:00 PM
 Room 202
Thursday, May 1, 2025
Departure
12:00–11:59 PM

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