Neurodegenerative disorders are a leading cause of disability and the second leading cause of death, therefore disease modifying therapeutics and biomarkers for early diagnosis and monitoring of target engagement during treatment are desperately required. Neurodegenerative diseases share many disease overarching mechanisms. These not only include the deposition of insoluble prion-like proteins but also strong non-neuronal contributions. Vascular and neuro-immunological risk factors are described for numerous neurodegenerative disorders. Moreover, peripheral modifiers of disease progression have been identified. A systemic view of neurodegeneration, which includes all non-neuronal brain cells and influences from peripheral organs, will open new avenues for the identification of diagnostic biomarkers and targeted disease overarching interventions. The conference will therefore cover a broad spectrum of neurodegenerative disorders and include targeted sessions to discuss system-wide mechanistic research and the exciting possibility to identify unexpected disease overarching therapeutic targets.