The rapid increase in RNA modification studies in higher organisms now established that chemical modifications of nucleotides regulate RNA metabolism, modulate cell functions and contribute to severe human diseases including cancer and metabolic disorders. Moreover, the power of single chemically modified nucleotides to alter the electrostatic charge, base pairing and stability of RNA molecules is exploited for clinical use of stable artificial RNA transcripts such as mRNA vaccines or synthetic small RNA molecules to increase or decrease the expression of therapeutic proteins. The meeting will highlight recent developments and focus on future aspects and current challenges of the field: 1. Novel molecular function of RNA modifications in regulating RNA metabolism 2. Critical evaluation of language models predicing RNA modifications & function 3. Discuss medicinal chemistry advances and bioengineering technologies (function in RNA-based treatment regimens) 4. Advances in RNA modification function in immune related diseases 5. Advances in RNA modification function in metabolic diseases and cancer 6. Highlight novel RNA therapeutics (RNA modifications as prognostic marker in disease) In summary, the meeting will provide a broad overview how basic science discoveries have unraveled the molecular and cellular functions of RNA modifications, provided new prospects for therapeutic manipulation and led to a range of innovative clinical approaches. Our program will bring together field-leading experts from across the globe covering multidisciplinary aspects of RNA modification research from chemistry, clinical applications, bioengineering and industry. Our comprehensive program provides young scientists with a broad view of state-of-the-art research in the field that is not available in other meetings or workshop centered around RNA more generally. Pairing the meeting with a meeting focusing on regulatory RNAs is highly beneficial as it provides an overview of not in depth covered emerging novel mechanisms how RNA regulate gene expression and cellular functions that could involve RNA modifications.