This meeting is focused on the tumor cell and the tumor intrinsic mechanisms involved in cancer. The sessions are intended to cover broad topics from cancer evolution, tumor heterogenity, metabolic rewiring and plasticity to drugging tumor intrinsic pathways and cancer cell vulnerabilities. Given the timeline for the meeting, we have included a session to focus on forward looking topics to discuss emerging topics and questions in the field from both academia and industry. Attendees will take away a broad based overview of the field that is uniquely focused on the tumor cell itself. The aim is for this meeting to complement the cancer immunotherapy focused meeting.