Systemic metabolism plays a critical role in controlling tumor development and provides several new opportunities to improve cancer therapy. The symposium will address topics that go beyond the impact of metabolic changes in the cancer cells themselves – the subject of many meetings – and explore the reciprocal relationship between tumors and whole-body metabolism. While systemic metabolism is important in the control of the immune system, this meeting is designed to explore other aspects of this important, but complex, area of research. The Symposium will cover diverse topics that impact will impact systemic metabolism and cancer, including the microbiome, diet (including obesity, cachexia and antioxidants), aging and other metabolic diseases. The aims of the meeting are to bring together fields that are only now beginning to intersect, to inspire a cohort of trainees to develop projects that span different disciplines and establish new collaborations, and to consider how progress in this area is being translated into clinical utility. The meeting will help to broaden the scope and complexity of cancer metabolism to consider the tumor in the context of the entire organism.