Significance: Proximity Based Modalities are a rapidly developing field at the intersection of biology, chemical biology, drug discovery and development, across a range of therapeutic areas. This rapid evolution requires collaboration and knowledge sharing amongst scientists in academic, non-profit and industry sectors to bring early induced proximity ideas from concept to chemical biology validation and ultimately into clinical development. The goals of this conference are to 1) foster connection between academic, industry and non-profit scientists, 2) provide perspective on the early discoveries of induced proximity, 3) provide a working knowledge of induced proximity mechanism of action, 4) inform on approaches to discover and develop induced proximity agents and 5) discuss the most recent advancements in the clinic. Innovation: Induced proximity (IP) is a rapidly evolving field that is includes protein degradation and other novel IP approaches that have significant therapeutic potential. New therapeutic modalities and paradigms do not arise often, and it is critical that academic, industry and non-profit scientist are regularly interacting to drive quality research, drug discovery and translation to clinical development. Providing a comprehensive perspective from concept and chemical biology to drug discovery and development will aid the field in realizing the scientific and medical opportunity that induced proximity approaches represent.