SIGNIFICANCE: A challenge of studying human neurodevelopmental conditions involves its heterogeneity in terms of etiologies, symptoms, disease course, and outcomes. As live human brain tissue is inaccessible, most studies involving the analysis of cellular function have been restricted to the examination of human postmortem tissues or animal models. While these approaches have yielded important insights, there are limitations regarding the transferability of these results to human physiology and psychiatry. Considering that, human induced pluripotent stem cells (iPSCs) appear as powerful models for studying predisposition to neurodevelopmental conditions with complex etiology as they allow researchers to uncover the idiosyncratic developmental deficits that arise from an individual's genetic landscape in combination with environmental disturbances. The goals of this symposium are: to discuss novel approaches for studying neurodevelopmental disorders; to connect scientists investigating global gene expression, neural patterning, maturation, inflammation, and synaptic function on neurons and astrocytes; to provide an interdisciplinary, stimulating, and high-level scientific environment related to psychiatric conditions or with a mutation related to brain development; to build knowledge in a two or tridimensional (brain organoids) culture systems. ANTICIPATED OUTCOMES: This meeting will promote the bringing of complementary expertise, providing an in-depth overview of the basis for neurodevelopmental conditions, the status of the art, cutting-edge technologies, and innovative approaches, benefiting attendees and fostering collaboration in science. INNOVATION: The meeting will narrow panels that will consider a variety of innovative techniques for generating neural cell types and analyzing cellular phenotypes relevant to psychiatric/ neurodevelopmental conditions, including glial-induced neuroinflammation and single-cell transcriptomics. The panels will also discuss the advantages and limitations of case/control studies and CRISPR-mediated gene editing for isogenic comparisons. The joining of our meeting with “developmental mechanisms and insights into disease” will favor an interdisciplinary, but somehow related scientific environment.