Antimicrobial resistance is an urgent public health threat that represents the single greatest challenge in infectious disease across the globe. The objective of this Keystone Symposium is to bring together a diverse group of world leaders focused on new and innovative strategies for combating antimicrobial resistant bacterial infections. The meeting will focus on emerging concepts for treating antimicrobial resistance across a wide array of clinically relevant bacterial pathogens. Specific focus will be given to three primary areas: i.) bacteriophage therapy, ii.) microbiome-based medicine, and iii.) harnessing of host immunity for treatment of bacterial infections. The symposium will fill a major need in the scientific community by integrating both basic and applied research with the goal of bringing together broad experts at various stages of the scientific process and creating an environment for building interactions and collaborations that will push the field forward. The meeting will hold unique and interactive sessions addressing the opportunities and challenges facing scientists, clinicians, and regulatory agencies in this rapidly evolving space. Speakers and attendees will represent leaders in academic research, industry, and government agencies from across the globe. The design of the symposium will encourage new collaborations and start conversations about the future of medicine without antibiotics.