The innate immune system serves to detect perturbations in organismal physiology and orchestrate responses that aim to reinstate homeostasis. Such perturbations sensed by innate immunity are diverse – including dangers such as infection, tissue injury and metabolic stress – and require a diversity of cells, receptors, and effector pathways to sense and interpret such signals, mount an appropriate innate immune response, and orchestrate inflammation resolution and wound healing. While such innate immune mechanisms are often host-protective, if they become unbalanced this can lead to infection or pathology. In this rapidly developing field, it is increasingly clear that maladaptive innate immune responses contribute to a myriad of diseases, including many human diseases associated with lifestyle and ageing (e.g. metabolic syndrome, neurodegeneration). This conference will bring together multidisciplinary perspectives on innate immunity, covering the fundamental science of innate immune mechanisms and the integration of immune diversity, including recent advances in innate immune danger-sensing and effector mechanisms across diverse cell types including macrophages, dendritic cells and epithelial barrier cells. As a joint meeting with the Keystone Aging Symposium, this meeting will allow valuable exchange and world-leading expertise in the fields of Ageing and Inflammation, to discuss the clinical aspects of inflammatory diseases associated with ageing, as well as industry approaches and emerging therapeutic opportunities for targeting inflammatory mechanisms in such diseases.