SIGNIFICANCE Stromal immunology describes the influence of fibroblasts and endothelial cells on immune cells and immune-driven outcomes. It underpins immune development, function and major pathologies such as infection, cancer, autoimmunity and fibrosis. Meeting goals: 1. To expand scientific frontiers by bringing together outstanding researchers solving important biomedical problems 2. To promote new breakthroughs in thought and practice by exposing siloed researchers to new findings that may be cross-disciplinary 3. To nurture emerging scientific leaders by providing a stimulating, inclusive environment to learn from and share with leaders in academia, clinical medicine and industry. We anticipate important knowledge gains including breakthroughs in understanding; the application of existing knowledge to new research frontiers; the emergence of new testing and technical modalities; and creation of collaborative and training opportunities. We want attendees to leave this meeting with exciting new ideas, and a topographical view of how stromal cells impact immunity across disciplines. INNOVATION The emerging collective identity of stromal immunology is already yielding transformative advances, reflected in the rapid increase in stromal-targeting therapies undergoing clinical experimentation. However, many efforts remain siloed in discrete disciplines, and our meeting will bring these scientists together. Career development and networking events are built into the program to foster collaboration and mentorship. Our pairing with the immune-driven fibrosis meeting is outstanding and unique. Both programs deal extensively with fibroblast function in homeostasis, inflammation, and immunity, including disease pathogenesis and therapeutic targeting. Our program covers emerging mechanism-driven insights in fibroblast development and function across a range of disease states dovetailed with fibrosis and matrix biology. Both meetings have strong relevance to a majority of attendees; thus we expect extensive interaction and cross-fertilization of ideas.