How individual cells coordinate tissue functions across cellular to organ level scales is a rapidly advancing area primed for discoveries. With increasingly powerful single-cell approaches we can now rapidly catalog the cell types, subsets, and states present in tissues, as well as localize these cells in space and in relation to each other, within the context of healthy and diseased contexts. These advances have precipitated a critical turning point in the field, where single cell data can now be effectively translated into biological and medical insights.

In this meeting we will build upon insights derived from studying individual cells to understand the rules and regulators of tissue structure, function and dysfunction. Specifically, the program will focus on:

1. biologically driven conceptual and technical advances in deconstructing and reconstructing tissues;
2. leveraging natural human and animal variation to identify new cell states and their clinical implications for translational research and drug discovery;
3. the development of novel methods to identify cellular and spatial modules that underlie health and disease.

This meeting will integrate biological concepts with experimental and computational approaches, bringing together scientists across techniques, tissues, organisms, and diseases to yield cross-disciplinary insights and advances. We hope that our meeting will provide a collaborative place for investigators who may not typically interact in the current structure of single-cell meetings to come together and share ideas and insights. By bringing these communities together we aim to  catalyze the next stage of discoveries in this field towards translational impacts.

This conference will be co-located with the Keystone Symposium on Organoids: Engineering Innovative Approaches for Basic and Translational Insight to enable cross-disciplinary insights and collaborations towards understanding the complex cellular ecosystem that makes up tissues and model organoids.