Stem Cells are defined by their ability to both self-renew and differentiate into multiple cell types. It is increasingly apparent that stem cells and their progeny underlying many critical aspects of development, tissue homeostasis, regeneration and repair. Advances in molecular and cellular biology have also stretched our understanding of how stem cell biology underlies these processes. Experimental and therapeutic interventions based on principals extracted from the stem cell field are now increasingly used to manipulate differentiated cell fates and overcome disease pathology. We plan a meeting that will unify the stem cell and aligned organoid field for one of the first major in-person gatherings to reflect on the discipline broadly and to discuss new important discoveries in this established field. the co-organization with the organoids field will help ensure that these two disciplines, one emerging and one well established are a major convening event for our community.