Microbiota and Cancer Immunity (K2)
March 17-20, 2024  | Humanities/Social Sciences Building of Academia Sinica, Taipei, Taiwan
Giorgio Trinchieri, Jenny P.Y. Ting, Hsing-Jien Kung and Shie-Liang Hsieh
Scholarship Deadline: Dec. 26, 2023 | Abstract Deadline: Dec. 26, 2023 | Early Registration Deadline: Jan. 17, 2024
This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities.
* Session Chair † Invited but not yet accepted | Program current as of July 22, 2024 | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, March 17, 2024
Arrival and Registration (4:00–8:00 PM)
Welcome Mixer (6:00–8:00 PM)
Monday, March 18, 2024
Welcome and Keynote Address (9:00–10:00 AM)
Keynote Address (9:00–10:00 AM)
Arlene H. Sharpe, Harvard Medical School
The Multi-Faceted Functions of the PD-1 Pathway
Microbiota and Immunity (10:00–12:15 PM)
Giorgio Trinchieri, NCI, National Institutes of Health
Microbiota and Cancer Immunotherapy
Kenya Honda, Keio University School of Medicine
Understanding Gut Microbiota and Its Possible Role in Preventing Cancer
Cheng-Yuan Kao, Amgen
Host Genes Shaping Gut Microbiota, Barrier Functions and Immune Responses
Sergei Grivennikov, Cedars-Sinai Medical Center
Short Talk: Microbiota Induced Cytokines Control Inflammation, Anti-Tumor Immunity and Colorectal Cancer Metastasis
Kylynda C Bauer †, National Institutes of Health - National Cancer Institute
Short Talk: Gut Microbiome-Brain Arc Shapes Liver Anti-Tumor Immunity
Lunch (12:15–1:15 PM)
Poster Session 1 (12:30–2:30 PM)
Panel: Effects of Race and Ethnicity on Microbiome: Impacts on Cancer Health Disparities (2:30–4:30 PM)
Coffee Available (4:30–5:00 PM)
Microbiota and Cancer (5:00–7:00 PM)
Sin-Hyeog Im, POSTECH
Modulation of Iron Sequestration by Commensal Microbes to Augment Tumor Immunity
Wen-Ching Wang, National Tsing Hua University
Strategic Evasion of Host Defense by Helicobacter pylori
Bertalan Takacs, Biological Research Centre, Szeged
Short Talk: Comparative Analysis of the Microbial Composition of Different Tumor Tissues
Polina Turbina, University of Luxembourg
Short Talk: A Personalised Cancer-on-Chip Model for the Study of Gut Microbiota in Colorectal Cancer Initiation and Progression
Jonas Schluter, NYU Langone Health
Short Talk: Cross-kingdom Ecosystem Dynamics in the Gut Influence Immunotherapy Outcomes and May Be Targeted Therapeutically
On Own for Dinner (7:00–8:00 PM)
Tuesday, March 19, 2024
Microbiota and Cancer Therapy (9:00–12:00 PM)
Marlies Meisel, University of Pittsburgh
Exercise-Induced Microbiota Changes Enhance Cancer Immunotherapy Efficacy in Melanoma
Yardena Samuels, Weizmann Institute of Science
Towards Deciphering the Neo-Antigenic and Microbial Landscapes in Melanoma
Marcel van den Brink, City of Hope
The Role of the Intestinal Microbiome in Cancer Immunotherapy
Laurence Zitvogel, Institut Gustave Roussy
Microbiota in Anti-Lung Cancer Immunotherapy
Ashray Gunjur, Wellcome Sanger Institute
Short Talk: A Pan-Cancer Gut Microbial Response Signature for Combination Immune Checkpoint Blockade Using Genome-Resolved Metagenomics
Luigi Nezi, European Institute of Oncology
Short Talk: Stability of the Gut Microbiota During Anti-pd1 Immunotherapy Defines Complete Response in Melanoma Patients
Lunch (12:00–1:00 PM)
Poster Session 2 (12:30–2:30 PM)
Career Roundtable (3:00–4:30 PM)
Cheng-Yuan Kao, Amgen
Principal Scientist - Inflammation Therapeutic Area
Florencia McAllister, MD Anderson Cancer Center
Physician Scientist/Associate Professor
Wanjun Chen, NIDCR, National Institutes of Health
Senior Investigator
Coffee Available (4:30–5:00 PM)
Innate Resistance (5:00–7:00 PM)
Andreas Diefenbach, Charité – Universitätsmedizin Berlin
IL-22 and Genotoxic Stress Response of Epithelial Stem Cells
Florencia McAllister, MD Anderson Cancer Center
Talk Title to be Announced
Kuo-I Lin, Academia Sinica
Signaling and Molecular Pathways Contributing to B Cell Chronic Lymphocytic Leukemia Progression and the Survival of Multiple Myeloma
Marco Colonna, Washington University School of Medicine
Pre-Recorded: TREM 2 in Cancer
On Own for Dinner (7:00–8:00 PM)
Wednesday, March 20, 2024
Innate and Immune Cells in the Tumor Microenvironment (9:00–12:00 PM)
Yi-Ching Wang, National Cheng Kung University
Post-Translational Modifications of PD-1 in Regulating T cell Functionality
Chen Dong, Tsinghua University
Pre-Recorded: Tumor Infiltrating Myeloid Cells and Impact on Checkpoint Inhibition
Mien-Chie Hung, China Medical University
Marker-Guided Effective Therapy (Mget) and Tumor Microenvironment
Ping-Chih Ho, Ludwig Institute for Cancer Research
Short Talk: Heme-Mediated Reprogramming on Guiding CD8+ T Cell Exhaustion in Response to Mitochondrial Dysfunction
Jian-Da Lin, National Taiwan University
Short Talk: Elucidating the Possible Associations Between Gut Microbiota and Immunity in Pancreatic Cancer with Single-Cell Multi-Omics Technology
Brendan Jenkins, The University of Adelaide
Short Talk: The Driver Role of Innate Immune Pattern Recognition Receptors in Pancreatic Cancer
Lunch (12:00–1:00 PM)
Workshop (2:30–4:30 PM)
Erik Thiele Orberg, University Clinic Rechts der Isar, Technical University Munich
Bacteria and Bacteriophage Consortia are Associated with Protective Intestinal Microbial Metabolites in Patients Receiving Stem Cell Transplantation
Kuan-lin Huang, Icahn School of Medicine at Mount Sinai
AI-Guided Prediction of Personalized Immunotherapy Outcomes
Jennifer Pak Yan Ho, Columbia University
Colon-Derived Ketone Bodies Modulate Metabolic Inflammation and Bacteria-Mediated Pro-Tumor Immunity
Xiaojing Ma, Weill Cornell Medical College
Targeting a Novel E3 Ubiquitin Ligase for Cancer Immunotherapy
Hung-Chia Hsieh, National Cheng Kung University
Deubiquitinase USP24 Suppresses T Cell Anti-Tumor Activity via Enhancement of PD-1 Protein Stability
Ching-Yu Lin, Taipei Medical University
Metabolic Modulation of Drug Resistance and Tumor Microenvironment in Prostate Cancer
Coffee Available (4:30–5:00 PM)
Tumor Immunity and Immunitherapeutics (5:00–6:00 PM)
* Yi-Ching Wang, National Cheng Kung University
Session Chair
Muh-Hwa Yang, National Yang Ming Chiao Tung University
Tumor-Associated Macrophages: Unveiling the Pathogenic Role and Unlocking the Therapeutic Potential
Robert Jenq, University of Texas MD Anderson Cancer Center
Short Talk: Bacteroides Ovatus Reduces Intestinal Graft-Versus-Host Disease Severity
Kai Trepka, University of California San Francisco
Short Talk: Oral Fluoropyrimidine Treatment Rapidly Alters the Gut Microbiota of Colorectal Cancer Patients, Selecting for Drug-Metabolizing Microbes
Closing Keynote Address (6:00–6:45 PM)
Jenny P.Y. Ting, University of North Carolina at Chapel Hill
The Impact of Innate Immune Receptor on Immunity, Cancer and the Microbiota
On Own for Dinner (7:00–8:00 PM)
Thursday, March 21, 2024
Departure (8:00–8:00 AM)