Joint with: Epigenetics in Development and Disease
Interplay of Chromatin Architecture and Transcription Regulation
March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Seychelle Vos, John T. Lis and Luca Giorgetti
In Person
On Demand
March 30–April 02, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Seychelle Vos, John T. Lis and Luca Giorgetti
Available Formats:
Supported by:
In Person
On Demand
Available Formats: = In Person = On Demand
Merchandise Options
Registration Options
Sunday, March 30, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Riverview Lounge
Welcome Mixer
6:00–8:00 PM
Riverview Lounge
Monday, March 31, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Cascade Ballroom
Patrick Cramer, Max Planck Institute for Biophysical Chemistry
Chromatin and Transcription
Chromatin and Transcription
Mechanisms of Gene Control and Epigenetic Regulation (Joint)
9:00–11:30 AM
Cascade Ballroom
Danny F Reinberg, University of Miami
Epigenetics and Inheritance
Epigenetics and Inheritance
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research
Transcription Factors and DNA Methylation
Transcription Factors and DNA Methylation
Lacramioara Bintu, Stanford University
Cofactors in Enhancer-Promoter Communication
Cofactors in Enhancer-Promoter Communication
François Fuks, University of Brussels
Short Talk: RNA Modifications in Health and Disease
Short Talk: RNA Modifications in Health and Disease
Thomas G Graham, University of California, Berkeley
Short Talk: Single-molecule Live Imaging of Transcriptional Regulatory Complex Interactions using Proximity-assisted Photoactivation (PAPA)
Short Talk: Single-molecule Live Imaging of Transcriptional Regulatory Complex Interactions using Proximity-assisted Photoactivation (PAPA)
Coffee Break
9:30–9:50 AM
Riverview Lounge
Award Recipient Acknowledgement
9:50–9:55 AM
Cascade Ballroom
Poster Setup
11:30–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Symposia Spotlight 1: Research presentations selected from abstract submissions
2:30–4:30 PM
Alhambra
Julia Schaepe, Stanford University
Thermodynamic Principles Link in vitro Transcription Factor Affinities to Single-molecule Chromatin States in Cells
Thermodynamic Principles Link in vitro Transcription Factor Affinities to Single-molecule Chromatin States in Cells
Allison James, Harvard Medical School
Structural Basis of Human CHD1 Nucleosome Recruitment and Pausing
Structural Basis of Human CHD1 Nucleosome Recruitment and Pausing
Blaine Bartholomew, MD Anderson Cancer Center
SWI/SNF Regulates Nuclear Condensates in an eRNA Dependent Manner
SWI/SNF Regulates Nuclear Condensates in an eRNA Dependent Manner
Sumitabha Brahmachari †, Rice University
The Dual Role of Nucleosomes in Transcription Regulation
The Dual Role of Nucleosomes in Transcription Regulation
Zachary A Drum, University of North Carolina at Chapel Hill
Mechanisms of Phase-separation Driven Chromatin Looping in Acute Myeloid Leukemia
Mechanisms of Phase-separation Driven Chromatin Looping in Acute Myeloid Leukemia
Erica N. Larschan, Brown University
Differential Competition between Similar Pioneer Transcription Factors Drives Gene Activation versus Gene Repression by Controlling the Size of Chromatin Loops
Differential Competition between Similar Pioneer Transcription Factors Drives Gene Activation versus Gene Repression by Controlling the Size of Chromatin Loops
Daniel Ibrahim, Berlin Institute of Health
Enhancer-promoter Specificity Mediated by the Promoter-proximal Region
Enhancer-promoter Specificity Mediated by the Promoter-proximal Region
Wen Yan, Pfizer
Identification Of A Selective And Orally Bioavailable BPTF PROTAC With Anti-Tumor Activity In SWI/SNF Mutant Lung Cancer
Identification Of A Selective And Orally Bioavailable BPTF PROTAC With Anti-Tumor Activity In SWI/SNF Mutant Lung Cancer
Coffee Available
4:30–5:00 PM
Riverview Lounge
Enhancer-Promoter Communication
5:00–7:00 PM
Alhambra
William Forrester †, Novartis
Talk Title to be Announced
Talk Title to be Announced
Jennifer E. Phillips-Cremins, University of Pennsylvania
Genome Looping and its Consequences on Transcription
Genome Looping and its Consequences on Transcription
Luca Giorgetti, Friedrich Miescher Institute for Biomedical Research
Dynamics of Chromatin Loops and the Consequence on Transcription
Dynamics of Chromatin Loops and the Consequence on Transcription
Mervenaz Koska †, Stanford University
Short Talk: Understanding the Mechanism of Promoter Competition
Short Talk: Understanding the Mechanism of Promoter Competition
Evgeny Kvon, University of California, Irvine
Short Talk: Bystander Chromatin Poising by Pioneer Factors Confers Aberrant Long-Range Enhancer Activation in Congenital Disease
Short Talk: Bystander Chromatin Poising by Pioneer Factors Confers Aberrant Long-Range Enhancer Activation in Congenital Disease
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Posters
7:30–10:00 PM
Alberta/New Brunswick
Tuesday, April 1, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Mechanisms of Chromatin Transcription
8:00–11:00 AM
Alhambra
Yanhui Xu, Fudan University
Structural Basis of Transcription Initiation on Chromatin
Structural Basis of Transcription Initiation on Chromatin
Stephen Buratowski, Harvard Medical School
Single Molecule Approaches to Study Transcription in a Chromatin Context
Single Molecule Approaches to Study Transcription in a Chromatin Context
Karen Arndt, University of Pittsburgh
Chromatin and Transcription Elongation
Chromatin and Transcription Elongation
Carl Wu, Johns Hopkins University
The biogenesis and regulation of chromatin accessibility for dynamic transcription complexes
The biogenesis and regulation of chromatin accessibility for dynamic transcription complexes
Sarah Hainer, University of Pittsburgh
Short Talk: Widespread Impact of Nucleosome Remodelers on Transcription at Cis-regulatory Elements
Short Talk: Widespread Impact of Nucleosome Remodelers on Transcription at Cis-regulatory Elements
Michael J Guertin, UConn Health
Short Talk: Mechanisms of Direct cis Repression by a Transcriptional Activator
Short Talk: Mechanisms of Direct cis Repression by a Transcriptional Activator
Coffee Break
9:00–9:20 AM
Riverview Lounge
Poster Setup
11:00–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:00–5:00 PM
Career Roundtable (Joint)
1:00–2:30 PM
Alhambra
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Coffee Break with Hot Chocolate, Firepits & Mountain Views
4:00–5:00 PM
Conservatory Terrace
Mechanisms and Dynamics of Genome Folding
5:00–7:00 PM
Alhambra
Tineke L Lenstra, Netherlands Cancer Institute
Understanding Transcription: One Molecule at a Time
Understanding Transcription: One Molecule at a Time
Xavier Darzacq, University of California, Berkeley
Quantifying the Molecular Transactions that Control Transcription in Live Cells
Quantifying the Molecular Transactions that Control Transcription in Live Cells
Marieke Oudelaar, Max Planck Institute for Biophysical Chemistry
Regulation of Gene Expression in the 3D Genome
Regulation of Gene Expression in the 3D Genome
Noura Maziak, Imperial College; LMS MRC
Short Talk: Extensive 3D Genome Reorganization Foreshadows Zygotic Genome Activation in Drosophila
Short Talk: Extensive 3D Genome Reorganization Foreshadows Zygotic Genome Activation in Drosophila
Erika Anderson, UCSF
Short Talk: Enhancers Regulate Transcription without Acting as Loading Sites for Extruding Cohesin
Short Talk: Enhancers Regulate Transcription without Acting as Loading Sites for Extruding Cohesin
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Posters
7:30–10:00 PM
Alberta/New Brunswick
Wednesday, April 2, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Pausing Dynamics/Transcription Termination
8:00–11:00 AM
Alhambra
John T. Lis, Cornell University
The Architecture and Functional Mechanisms of Active Human Enhancers
The Architecture and Functional Mechanisms of Active Human Enhancers
Seychelle Vos, Massachusetts Institute of Technology
Pausing and Release into Productive Elongation
Pausing and Release into Productive Elongation
Lidia Vasilieva, University of Oxford
Kinases, Phosphatases and their Role in Transcription Termination
Kinases, Phosphatases and their Role in Transcription Termination
Benjamin R. Sabari, University of Texas Southwestern Medical Center
Short Talk: Gain-of-function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions
Short Talk: Gain-of-function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions
William Lai, Cornell University
Short Talk: High-resolution Mapping of the Pol II and Pol III Regulatory Complexes under Transcriptional Perturbation
Short Talk: High-resolution Mapping of the Pol II and Pol III Regulatory Complexes under Transcriptional Perturbation
Katerina Kraft, Stanford
Short Talk: Enhancer Activation from Transposable Elements in Extrachromosomal DNA
Short Talk: Enhancer Activation from Transposable Elements in Extrachromosomal DNA
Roberto Vazquez Nunez, Massachusetts Institute of Technology
Short Talk: GATO-Seq Uncovers RNA Polymerase II Promoter-Proximal Pausing Dynamics
Short Talk: GATO-Seq Uncovers RNA Polymerase II Promoter-Proximal Pausing Dynamics
Coffee Break
9:00–9:20 AM
Riverview Lounge
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Research presentations selected from abstract submissions
2:30–4:30 PM
Alhambra
Kalon J Overholt, MIT
High-resolution Footprints in Chromatin Architecture Enable Discovery of Transcription Factor Nano-assemblies
High-resolution Footprints in Chromatin Architecture Enable Discovery of Transcription Factor Nano-assemblies
Michael Quezada, Harvard Medical School
High-throughput Characterization of Interactions between Transcription Factors and Intrinsically Disordered Regions with Optical Pooled Screening
High-throughput Characterization of Interactions between Transcription Factors and Intrinsically Disordered Regions with Optical Pooled Screening
Havva Ortabozkoyun, University of Miami / HHMI
Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries
David Gross, Louisiana State University Health Sciences Center
Identification of Regulators that Drive Dynamic, Heat Shock-Induced Genome Restructuring
Identification of Regulators that Drive Dynamic, Heat Shock-Induced Genome Restructuring
Darko Barisic, Weill Cornell Medicine
Mammalian SWI/SNF Remodeling Complexes Regulate Chromatin Topology and Mitotic Stability by Antagonizing CTCF and Cohesin on Chromatin
Mammalian SWI/SNF Remodeling Complexes Regulate Chromatin Topology and Mitotic Stability by Antagonizing CTCF and Cohesin on Chromatin
Katherine Fleck †, University of Connecticut
Novel Gene Evolution and 3D Chromatin Organization
Novel Gene Evolution and 3D Chromatin Organization
Matt Franklin, Stanford University
Human Satellite 3 DNA Encodes Megabase-scale Transcription Factor Binding Platforms
Human Satellite 3 DNA Encodes Megabase-scale Transcription Factor Binding Platforms
Djem Kissiov, University of California, Berkeley
Decoupling Transcriptional Memory from Chromatin Structure through Analysis of Single Chromatin Fibers
Decoupling Transcriptional Memory from Chromatin Structure through Analysis of Single Chromatin Fibers
Coffee Available
4:30–5:00 PM
Riverview Lounge
Keynote Address (Joint)
5:00–5:45 PM
Cascade Ballroom
Mark A. Dawson, Peter MacCallum Cancer Centre
Functional Genomics to Study Transcription Factors and Chromatin Remodelers in Cancer
Functional Genomics to Study Transcription Factors and Chromatin Remodelers in Cancer
Transcription and Epigenetics in Disease (Joint)
5:45–7:15 PM
Cascade Ballroom
Paola Scaffidi, European Institute of Oncology
Epigenetics and Functional Intratumor Heterogeneity
Epigenetics and Functional Intratumor Heterogeneity
Gromek Smolen, Foghorn Therapeutics
Targeting Chromatin Modulators with Therapeutic Degraders
Targeting Chromatin Modulators with Therapeutic Degraders
Tony Kouzarides, Cambridge Gravity, University of Cambridge
Regulation of Gene Expression by RNA Modifications
Regulation of Gene Expression by RNA Modifications
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
7:15–7:30 PM
Cascade Ballroom
Social Hour with Lite Bites
7:30–8:30 PM
Alberta/New Brunswick
Trivia!
8:30–9:30 PM
Cascade Ballroom
Thursday, April 3, 2025
Departure
12:00–11:59 PM
Subscribe for Updates