Microproteins: from Discovery to Applications

Feb 06–08, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

  In Person
  On Demand

Feb 06–08, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

Available Formats:   = In Person     = On Demand
Thursday, February 6, 2025
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Friday, February 7, 2025
Breakfast
7:30–8:30 AM
Poster Setup
8:00–8:30 AM
Poster Viewing
8:00–5:00 PM
Welcome and Keynote Address
8:30–9:30 AM
Jonathan W. Yewdell, NIAID, National Institutes of Health
Noncanonical Translation as a Source of Novel Antigens
Microprotein Annotation Across Species
9:30–12:00 PM
Anne-Ruxandra Carvunis, University of Pittsburgh
Systems Approaches to Unravel Microprotein Biology in S. cerevisiae
Kousuke Hanada, Kyushu Institute of Technology
Identification and Characterization of Microproteins in Arabidopsis
Julie Aspden, University of Leeds
Discovery of Non-Canonical Peptides during Neuronal Differentiation
Ariel Alejandro Bazzini †, Stowers Institute for Medical Research
Short Talk: Translation of Small Downstream Orfs (Dorf) Enhances Translation of Canonical Main Open Reading Frames
Gisela Storz †, NICHD, NIH
Short Talk: Regulating Membrane Protein Stability with Small Proteins
Coffee Break
10:00–10:20 AM
Lunch
12:00–1:00 PM
Posters 1
12:30–3:00 PM
Coffee Available
3:00–3:30 PM
Disease-Regulating Microproteins
3:30–5:30 PM
Thomas F. Martínez, University of California, Irvine
Uncovering Novel Microprotein Regulators of Squamous Cell Carcinoma Growth
Jennifer Snead, Velia
Talk Title to be Announced
Catherine A. Makarewich, Cincinnati Children's Hospital Medical Center
Microproteins Implicated in Heart Failure
Jin Chen, Altos Labs
Functional Genomics Strategies Reveal Microproteins Involved in Disease
On Own for Dinner
5:30–9:30 PM
Transportation to Dinner Options
5:45–9:30 PM
Saturday, February 8, 2025
Breakfast
7:30–8:30 AM
Microprotein Interactions and Functions
8:30–11:30 AM
Lena Ho, Duke-NUS Medical School
Microprotein Interactions with Mitochondrial Protein Complexes
Christine Brun, TAGC Inserm-Univ. Mediterranee
Computational Predictions of Microprotein Interactions
Sarah Slavoff, Yale University
Microproteins and Chromatin Modifying-Proteins
Short Talk(s) Chosen from Abstracts
Ryan L. Boudreau †, University of Iowa
Short Talk: A Misannotated LncRNA that is Dysregulated in Alzheimer’s Disease Encodes a Microprotein that Influences Amyloid Beta Processing and Learning and Memory in Mice
Yiwen Chen, University of Texas MD Anderson Cancer Center
Short Talk: Large-Scale Approaches to Unravel the Functions of the “Dark” Proteome in Cancer Signaling Pathways
Hao Gong †, Queensland Brain Institute
Short Talk: Exploring the Role of Translatable Circular Rnas During the Formation of Fear Extinction Memory
Jasmyn Hoeger †, University of Iowa- Internal Medicine-Cardiovascular Medicine
Short Talk: Discovery and Initial Characterization of a Diverse Family of Microproteins Derived from Alternative Open Reading Frames in SCN(NaV) Genes
Coffee Break
9:30–9:50 AM
Lunch
11:30–12:30 PM
Posters 2
12:00–2:30 PM
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Nasim Akbari †, University of Saskatchewan
The Human Microproteins Encoded by Long Non-Coding Rnas LINC00888 and LINC00887 are Potent Restriction Factors for Enterovirus D68
Igor Fesenko, NIH
Evolution of Bacterial Microproteome
Puri Fortes †, Foundation for Applied Medical Research
Microproteins Translated from Long Non-Coding Rnas Expressed in Liver and Breast Cancer are Required for Cell Growth and Produce Tumor-Specific Antigens of Interest for Anticancer Vaccination
Vighnesh V Ghatpande †, The University of Texas at Austin
Single-Embryo Ribosome Profiling Reveals Pervasive Non-Canonical Translation Oof Micropeptides During Early Mouse Embryonic Development
Beyza-Nur Güven, Goethe-University Frankfurt
The Inflammation-Induced Microprotein Mip-PSTPIP2 Modulates Intracellular Trafficking and Endothelial Cell Activation
Fabricio Loayza-Puch †, German Cancer Research Center
The Inflammation-Induced Microprotein Mip-PSTPIP2 Modulates Intracellular Trafficking and Endothelial Cell Activation
Neelanjan Mukherjee †, University of Colorado School of Medicine
Proteogenomic Discovery of Neoepitopes in Human Beta Cells
Daniel Rebibo, Sanford Burnham Prebys
Characterizing the MYC-Regulated Microproteome in B-Cell Lymphoma
Coffee Available
4:30–5:00 PM
The Functional Potential of Natural and Synthetic Microproteins
5:00–6:45 PM
Gabriel Jacob Rocklin, Northwestern University
Stability and Dynamics of Miniproteins at Scale
Xuebing Wu, Columbia University
Noncoding Translation Mitigation
Aaron Wacholder, University of Pittsburgh School of Medicine
Evolutionary Multi-Omics Strategies for Microprotein Characterization
Alex S Holehouse †, Washington University in St. Louis
Short Talk: Prediction of Microprotein Conformational Ensembles and Intermolecular Interactions from Sequence
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Dinner
7:00–8:00 PM
Sunday, February 9, 2025
Departure
8:00–9:00 AM

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