Microproteins: from Discovery to Applications

Feb 06–08, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

  In Person
  On Demand

Feb 06–08, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

Supported by the  Directors' Fund
Available Formats:   = In Person     = On Demand
Thursday, February 6, 2025
Registration  
4:00–8:00 PM
 Conference Center Atrium
Welcome Mixer  
6:00–8:00 PM
 Conference Center Atrium
Friday, February 7, 2025
Breakfast  
7:30–8:30 AM
 Conference Center Atrium
Poster Setup  
8:00–8:30 AM
 Ipswich
Poster Viewing  
8:00–5:00 PM
 Ipswich
Welcome and Keynote Address  
8:30–9:30 AM
 Beverly Room
* Thomas F. Martínez, University of California, Irvine
Sarah Slavoff, Yale University
Microproteins and Chromatin Modifying-Proteins
Microprotein Annotation Across Species  
9:30–12:00 PM
 Beverly Room
* Lin Chou, University of Pittsburgh
Session Chair
Anne-Ruxandra Carvunis, University of Pittsburgh
Systems Approaches to Unravel Microprotein Biology in S. cerevisiae
Kousuke Hanada, Kyushu Institute of Technology
Identification and Characterization of Microproteins in Arabidopsis
Julie Aspden, University of Leeds
Discovery of Non-Canonical Peptides during Neuronal Differentiation
Claudio Casola, Texas A&M University
Short Talk: Degradation Determinants are Abundant in Human Microproteins
Coffee Break  
10:00–10:20 AM
 Beverly Foyer
Lunch  
12:00–1:00 PM
 Newburyport
Women in Science Networking Event  
12:05–1:05 PM
 Hamilton
* Lena Ho, Duke-NUS Medical School
Session Chair
* Anne-Ruxandra Carvunis, University of Pittsburgh
Session Chair
Poster Session 1  
12:45–3:00 PM
 Ipswich
Coffee Available  
3:00–3:30 PM
 Beverly Foyer
Disease-Regulating Microproteins  
3:30–5:30 PM
 Beverly Room
* Miranda E Kelly, University of California, Irvine
Thomas F. Martínez, University of California, Irvine
Investigation of Oncogenic KRAS-regulated Microproteins in Pancreatic Ductal Adenocarcinoma
Erin E. Duffy, Harvard Medical School
Developmental Dynamics of Microprotein Translation in the Human Brain
Catherine Makarewich, Cincinnati Children's Hospital Medical Center
Microproteins Implicated in Heart Failure
Jin Chen, Altos Labs
Functional Genomics Strategies Reveal Microproteins Involved in Disease
On Own for Dinner  
5:30–9:30 PM
Transportation to Dinner Options  
5:45–9:30 PM
Saturday, February 8, 2025
Breakfast  
7:30–8:30 AM
 Conference Center Atrium
Poster Setup  
8:00–8:30 AM
 Ipswich
Poster Viewing  
8:00–5:00 PM
 Ipswich
Microprotein Interactions and Functions  
8:30–11:30 AM
 Beverly Room
* Carly Houghton, University of Pittsburgh
Session Chair
Lena Ho, Duke-NUS Medical School
EMBO Young Investigator Lecture: Microprotein Interactions with Mitochondrial Protein Complexes
Christine Brun, TAGC Inserm-Univ. Mediterranee
Computational Predictions of Microprotein Interactions
Ariel Alejandro Bazzini, Stowers Institute for Medical Research
Translation of Small Downstream Orfs (Dorf) Enhances Translation of Canonical Main Open Reading Frames
Ryan L Boudreau, University of Iowa
Short Talk: A Misannotated LncRNA that is Dysregulated in Alzheimer’s Disease Encodes a Microprotein that Influences Amyloid Beta Processing and Learning and Memory in Mice
Yiwen Chen, University of Texas MD Anderson Cancer Center
Short Talk: Large-Scale Approaches to Unravel the Functions of the “Dark” Proteome in Cancer Signaling Pathways
Jasmyn Hoeger, University of Iowa
Short Talk: Discovery and Initial Characterization of a Diverse Family of Microproteins Derived from Alternative Open Reading Frames in SCN(NaV) Genes
Coffee Break  
9:30–9:50 AM
 Beverly Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
 Beverly Room
Lunch  
11:30–12:30 PM
 Newburyport
Poster Session 2  
12:00–2:30 PM
 Ipswich
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions  
2:30–4:30 PM
 Beverly Room
* Lena Ho, Duke-NUS Medical School
Anil Kumar, University of Saskatchewan
The Human Microproteins Encoded by Long Non-Coding Rnas LINC00888 and LINC00887 are Potent Restriction Factors for Enterovirus D68
Mauro Siragusa, Goethe University
Identification and Functional Characterization of Endothelial Cell Microproteins Encoded by Non-Canonical Open Reading Frames.
Vighnesh V Ghatpande, The University of Texas at Austin
Non-canonical Translation during Early Mouse Embryonic Development
Beyza-Nur Güven, Goethe-University Frankfurt
The Inflammation-Induced Microprotein Mip-PSTPIP2 Modulates Intracellular Trafficking and Endothelial Cell Activation
Fabricio Loayza-Puch, German Cancer Research Center
Upstream Open Reading Frame Translation Generates Microproteins and Enhances Immunogenic Peptide Presentation in Mitotically Arrested Cancer Cells
Neelanjan Mukherjee, University of Colorado School of Medicine
Proteogenomic Discovery of Neoepitopes in Human Beta Cells
Daniel Rebibo, Sanford Burnham Prebys
Characterizing the MYC-Regulated Microproteome in B-Cell Lymphoma
Maria Abad, Altos Labs
Mining the Hidden Microproteome for Key Drivers of Cellular Plasticity
Coffee Available  
4:30–5:00 PM
 Beverly Foyer
The Functional Potential of Natural and Synthetic Microproteins  
5:00–6:45 PM
 Beverly Room
* Anne-Ruxandra Carvunis, University of Pittsburgh
Xuebing Wu, Columbia University
Noncoding Translation Mitigation
Aaron Wacholder, University of Pittsburgh School of Medicine
Evolutionary Multi-Omics Strategies for Microprotein Characterization
Alex S Holehouse, Washington University in St. Louis
Prediction of Microprotein Conformational Ensembles and Intermolecular Interactions from Sequence
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Beverly Room
Dinner  
7:00–8:00 PM
 Tupper Manor Ballroom
Sunday, February 9, 2025
Departure  
8:00–9:00 AM