Targeting Dry Age-related Macular Degeneration: Pathophysiology and Emerging Therapies
September 17-20, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers:
Wai T. Wong and Aparna Lakkaraju
In Person
On Demand
September 17-20, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers:
Wai T. Wong and Aparna Lakkaraju
Available Formats:
In Person
On Demand
Supported by BrightFocus Foundation
Available Formats: = In Person = On Demand
Booking Function
Tuesday, September 17, 2024
Fundraising
Merchandise Options
Registration Options
Registration
4:00–6:00 PM
Kiln
Pre-Dinner Drinks and Mixer
5:00–6:00 PM
Kiln
Dinner
6:00–7:00 PM
Crocker Dining Room
Welcome Mixer
7:00–9:00 PM
Kiln
Wednesday, September 18, 2024
Breakfast
7:30–8:30 AM
Crocker Dining Room
Welcome and Keynote Address
8:30–9:30 AM
Fred Farr Forum
Botond Roska, Institute of Ophthalmology Basel
Optogenetic Vision Restoration
Optogenetic Vision Restoration
Speaker Session 1: Drusen in Intermediate AMD: How do they Arise, how they Drive Disease, how do we Treat?
9:30–10:55 AM
Fred Farr Forum
Imre Lengyel, Queen's University Belfast
Overview of Drusenoid Deposits in AMD and their Pathophysiology
Overview of Drusenoid Deposits in AMD and their Pathophysiology
Robyn H Guymer, Centre for Eye Research Australia
Targeting Intermediate AMD as a Therapeutic Concept
Targeting Intermediate AMD as a Therapeutic Concept
Goldis Malek, Duke University
Lipid Dysregulation as a Mechanism for Drusen Formation and a Target
Lipid Dysregulation as a Mechanism for Drusen Formation and a Target
Coffee Break
10:45–11:15 AM
Fred Farr Forum
Session 1 Panel Discussion: Drusen in Intermediate AMD: How do they Arise, how they Drive Disease, how do we Treat? (Drs. Lengyel, Guymer and Malek)
11:15–11:50 AM
Fred Farr Forum
Lunch
12:00–1:00 PM
Crocker Dining Room
Poster Setup
12:00–1:00 PM
Kiln
Free Time/Scheduled Activities
1:00–2:30 PM
Workshop Session 1: Pros and Cons of in vivo and in vitro Models to Study AMD Pathology
2:30–3:15 PM
Fred Farr Forum
* David Williams †, UCLA
Session Chair
Session Chair
Nathan Boles †, Neural Stem Cell Institute
Panelist
Panelist
Holly Chen †, University of Alabama at Birmingham
Panelist
Panelist
Patsy Nishina †, The Jackson Laboratory
Panelist
Panelist
Workshop Session 2: Translating Research Findings to Therapeutic Applications and Innovations
3:15–4:00 PM
Fred Farr Forum
* Marie Csete †, OkuloVision Inc
Session Chair
Session Chair
John G Flannery †, University of California, Berkeley
Panelist
Panelist
Erik Karrer †, Character Biosciences
Panelist
Panelist
Cheryl Rowe-Rendleman †, Omar Consulting Group, LLC
Panelist
Panelist
Rusty Kelley †, Foundation Fighting Blindness
Panelist
Panelist
Coffee Available
4:00–4:15 PM
Fred Farr Forum
Speaker Session 2: Geographic Atrophy (GA) in Advanced AMD: Mechanisms Underlying Disease Progression
4:15–5:30 PM
Fred Farr Forum
Emily Chew, NEI, National Institutes of Health
Nature of the Beast: How GA Arises and Grows and what are the Drivers?
Nature of the Beast: How GA Arises and Grows and what are the Drivers?
Robert Mullins, University of Iowa
Choroidal Vascular Change: How it Drives GA and how we can Target It
Choroidal Vascular Change: How it Drives GA and how we can Target It
James Handa, Johns Hopkins University
Mechanisms Driving RPE Demise: What they are and how to Target?
Mechanisms Driving RPE Demise: What they are and how to Target?
Session 2 Panel Discussion: Geographic Atrophy (GA) in Advanced AMD: Mechanisms Underlying Disease Progression (Drs. Chew, Mullins and Handa)
5:30–5:55 PM
Fred Farr Forum
Dinner
6:00–7:00 PM
Crocker Dining Room
Poster Session 1
7:00–9:00 PM
Kiln
Thursday, September 19, 2024
Breakfast
7:30–8:30 AM
Crocker Dining Room
Speaker Session 3: Pathogenic Mechanisms and Targets in Non-Exudative AMD: Complement and Beyond
8:30–10:15 AM
Fred Farr Forum
Anneke Den Hollander, AbbVie
What (Gen)omics are Telling us about the Etiology of AMD
What (Gen)omics are Telling us about the Etiology of AMD
Florian Sennlaub, Institut de la Vision
Neuroinflammatory Mechanisms Driving Atrophy in GA
Neuroinflammatory Mechanisms Driving Atrophy in GA
Aparna Lakkaraju, University of California, San Francisco
Multifunctional Therapeutics for AMD: Complement, Lipids, and Neuroprotection
Multifunctional Therapeutics for AMD: Complement, Lipids, and Neuroprotection
Session 3 Panel Discussion: Pathogenic Mechanisms and Targets in Non-Exudative AMD: Complement and Beyond (Drs. Den Hollander, Sennlaub and Lakkaraju)
10:00–10:20 AM
Fred Farr Forum
* Sarah L. Doyle, Trinity College Dublin
Session Chair
Session Chair
Coffee Break
10:20–10:45 AM
Fred Farr Forum
Short Talks From Abstracts
10:45–11:45 AM
Fred Farr Forum
Glenn Yiu, University of California, Davis
Drusen and AMD: Insights from Nonhuman Primates
Drusen and AMD: Insights from Nonhuman Primates
Emily Tom, University of California, Irvine
Rescue of Age-related Vision Decline: Targeting ELOVL2-Mediated Fatty Acid Elongation
Rescue of Age-related Vision Decline: Targeting ELOVL2-Mediated Fatty Acid Elongation
Ruchi Sharma †, NEI/NIH
Human Endogenous Retrovirus (HERV)-K Upregulation Triggers Degeneration in Induced Pluripotent Stem Cell Derived Retinal Pigment Epithelium (Ipsc-RPE) and Mice Model
Human Endogenous Retrovirus (HERV)-K Upregulation Triggers Degeneration in Induced Pluripotent Stem Cell Derived Retinal Pigment Epithelium (Ipsc-RPE) and Mice Model
Kaitryn E Ronning, Sorbonne Université
Deregulation of the Inflammatory Reflex Exacerbates Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration
Deregulation of the Inflammatory Reflex Exacerbates Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration
Lunch
12:00–1:00 PM
Crocker Dining Room
Free Time/Scheduled Activities
1:00–3:30 PM
Coffee Available
3:30–3:45 PM
Fred Farr Forum
Speaker Session 4: Therapeutic Approaches Moving to the Clinic: The Present and the Future
3:45–5:00 PM
Fred Farr Forum
Speaker to be Announced
Wai T. Wong, Johnson & Johnson
Neuroinflammatory Targets for the Treatment of GA
Neuroinflammatory Targets for the Treatment of GA
Valeria Canto-Soler, University of Colorado School of Medicine
Cell Transplantation as a Treatment for GA
Cell Transplantation as a Treatment for GA
Session 4 Panel Discussion: Therapeutic Approaches Moving to the Clinic: The Present and the Future (Drs. Wong and Canto-Soler)
5:00–5:20 PM
Fred Farr Forum
* Deepak Lamba, Genentech
Session Chair
Session Chair
Short Talks From Abstracts
5:20–6:20 PM
Fred Farr Forum
Douglas Vollrath †, Stanford University School of Medicine
A Critical Role for RPE Coenzyme Q Oxidation in Outer Retinal Health
A Critical Role for RPE Coenzyme Q Oxidation in Outer Retinal Health
Cristhian J Ildefonso, University of Florida College of Medicine
Unraveling the Role of the Mitochondrial Common Deletion on RPE Function
Unraveling the Role of the Mitochondrial Common Deletion on RPE Function
Lindsey A Chew, Duke University
Truncated Complement Factor H (Y402) Gene Therapy Restores Complement Regulation in Multiple Organ Systems
Truncated Complement Factor H (Y402) Gene Therapy Restores Complement Regulation in Multiple Organ Systems
Jessica D Gumerson, REGENXBIO
Suprachoroidal Delivery of a Novel Capsid Expressing a C5 Inhibitor as a Potential Treatment for Dry Age-Related Macular Degeneration
Suprachoroidal Delivery of a Novel Capsid Expressing a C5 Inhibitor as a Potential Treatment for Dry Age-Related Macular Degeneration
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:20–6:30 PM
Fred Farr Forum
Banquet Dinner
6:30–7:30 PM
Crocker Dining Room
Poster Session 2
7:30–9:30 PM
Kiln
Friday, September 20, 2024
Breakfast
7:30–9:00 AM
Crocker Dining Room
Career Roundtable: Career Research Paths in Academia vs. Government vs. Industry
9:00–10:00 AM
Fred Farr Forum
Early Career/Grant Writing: Early Career Development in Vision Research, Choosing and Starting a Research Focus and Writing a First Grant
10:00–11:00 AM
Fred Farr Forum
Checkout/Departure
11:00–1:00 PM
Social Hall
Lunch
12:00–1:00 PM
Crocker Dining Room
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