Targeting Dry Age-related Macular Degeneration: Pathophysiology and Emerging Therapies

Sep 17–20, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Wai T. Wong and Aparna Lakkaraju

  In Person
  On Demand

Sep 17–20, 2024 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers: Wai T. Wong and Aparna Lakkaraju

Available Formats:   = In Person     = On Demand
Tuesday, September 17, 2024
Registration  
4:00–6:00 PM
 Kiln
Pre-Dinner Drinks and Mixer  
5:00–6:00 PM
 Kiln
Dinner for Hotel Guests  
6:00–7:00 PM
 Crocker Dining Room
Welcome Mixer and Registration  
7:00–9:00 PM
 Kiln
Wednesday, September 18, 2024
Breakfast for Hotel Guests  
7:30–9:00 AM
 Crocker Dining Room
Poster Setup  
8:00–12:00 PM
 Kiln
Welcome Remarks
8:50–9:00 AM
 Fred Farr Forum
* Wai T. Wong, Tiresias Biopharma Consulting
* Aparna Lakkaraju, University of California, San Francisco
Keynote Address  
9:00–10:00 AM
 Fred Farr Forum
Botond Roska, Institute of Molecular and Clinical Ophthalmology (IOB) Basel
Optogenetic Vision Restoration
Speaker Session 1: Drusen in Intermediate AMD: How do they Arise, how they Drive Disease, how do we Treat?  
10:00–11:15 AM
 Fred Farr Forum
Imre Lengyel, Queen's University Belfast
Overview of Drusenoid Deposits in AMD and their Pathophysiology
Robyn H Guymer, Centre for Eye Research Australia
Targeting Intermediate AMD as a Therapeutic Concept
Goldis Malek, Duke University
Lipid Dysregulation as a Mechanism for Drusen Formation and a Target
Coffee Break  
11:00–11:15 AM
 Fred Farr Forum
Session 1 Panel Discussion: Drusen in Intermediate AMD: How do they Arise, how they Drive Disease, how do we Treat? (Drs. Lengyel, Guymer and Malek)  
11:15–11:50 AM
 Fred Farr Forum
* Wai T. Wong, Tiresias Biopharma Consulting
Moderator
Lunch for Hotel Guests  
12:00–1:00 PM
 Crocker Dining Room
Women in Science Networking Event
12:00–1:00 PM
 Crocker Dining Room
Poster Viewing  
1:00–9:00 PM
 Kiln
Free Time/Scheduled Activities  
1:00–2:30 PM
Workshop Session 1: Pros and Cons of in vivo and in vitro Models to Study AMD Pathology  
2:30–3:15 PM
 Fred Farr Forum
* David Williams, UCLA
Moderator
Nathan Boles, Neural Stem Cell Institute
Panelist
Holly Chen, University of Alabama at Birmingham
Panelist
Patsy Nishina, The Jackson Laboratory
Panelist
Workshop Session 2: Translating Research Findings to Therapeutic Applications and Innovations  
3:15–4:00 PM
 Fred Farr Forum
* Marie Csete, OkuloVision Inc
Moderator
John G Flannery, University of California, Berkeley
Panelist
Erik Karrer, Character Biosciences
Panelist
Sri Mudumba, PYC Therapeutics
Panelist
Rusty Kelley, Foundation Fighting Blindness
Panelist
Coffee Available  
4:00–4:15 PM
 Fred Farr Forum
Speaker Session 2: Geographic Atrophy (GA) in Advanced AMD: Mechanisms Underlying Disease Progression  
4:15–5:30 PM
 Fred Farr Forum
Emily Chew, NEI, National Institutes of Health
Nature of the Beast: How GA Arises and Grows and what are the Drivers?
Robert Mullins, University of Iowa
Choroidal Vascular Change: How it Drives GA and how we can Target It
James Handa, Johns Hopkins University
Mechanisms Driving RPE Demise: What they are and how to Target?
Session 2 Panel Discussion: Geographic Atrophy (GA) in Advanced AMD: Mechanisms Underlying Disease Progression (Drs. Chew, Mullins and Handa)  
5:30–5:55 PM
 Fred Farr Forum
* Patricia A. D'Amore, Mass Eye and Ear, Harvard Medical School
Moderator
Dinner for Hotel Guests  
6:00–7:00 PM
 Crocker Dining Room
Poster Session 1  
7:00–9:00 PM
 Kiln
Thursday, September 19, 2024
Breakfast for Hotel Guests  
7:30–8:30 AM
 Crocker Dining Room
Poster Setup  
8:00–12:00 PM
 Kiln
Speaker Session 3: Pathogenic Mechanisms and Targets in Non-Exudative AMD: Complement and Beyond  
8:30–9:45 AM
 Fred Farr Forum
Anneke Den Hollander, AbbVie
What (Gen)omics are Telling us about the Etiology of AMD
Florian Sennlaub, Institut de la Vision
Neuroinflammatory Mechanisms Driving Atrophy in GA
Aparna Lakkaraju, University of California, San Francisco
Multifunctional Therapeutics for AMD: Complement, Lipids, and Neuroprotection
Session 3 Panel Discussion: Pathogenic Mechanisms and Targets in Non-Exudative AMD: Complement and Beyond (Drs. Den Hollander, Sennlaub and Lakkaraju)  
9:45–10:15 AM
 Fred Farr Forum
* Sarah L. Doyle, Trinity College Dublin
Moderator
Coffee Break  
10:15–10:45 AM
 Fred Farr Forum
Short Talks From Abstracts  
10:45–11:45 AM
 Fred Farr Forum
* Sydney Williams, UCSF
Moderator
Glenn Yiu, University of California, Davis
Short Talk: Drusen and AMD: Insights from Nonhuman Primates
Emily Tom, University of California, Irvine
Short Talk: Rescue of Age-related Vision Decline: Targeting ELOVL2-Mediated Fatty Acid Elongation
Ruchi Sharma, NEI/NIH
Short Talk: Human Endogenous Retrovirus (HERV)-K Upregulation Triggers Degeneration in Induced Pluripotent Stem Cell Derived Retinal Pigment Epithelium (Ipsc-RPE) and Mice Model
Kaitryn E Ronning, Sorbonne Université
Short Talk: Deregulation of the Inflammatory Reflex Exacerbates Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration
Lunch for Hotel Guests  
12:00–1:00 PM
 Crocker Dining Room
Poster Viewing  
1:00–9:30 PM
 Kiln
Free Time/Scheduled Activities  
1:00–3:30 PM
Coffee Available  
3:15–3:30 PM
 Fred Farr Forum
Speaker Session 4: Therapeutic Approaches Moving to the Clinic: The Present and the Future  
3:30–4:55 PM
 Fred Farr Forum
Alex McKeown, Apellis Pharmaceuticals
Treatments for GA: Intravitreal Pegcetacoplan and Beyond
Wai T. Wong, Tiresias Biopharma Consulting
Neuroinflammatory Targets for the Treatment of GA
Valeria Canto-Soler, University of Colorado School of Medicine
Cell Transplantation as a Treatment for GA
Session 4 Panel Discussion: Therapeutic Approaches Moving to the Clinic: The Present and the Future (Drs. McKeown, Wong and Canto-Soler)  
4:55–5:25 PM
 Fred Farr Forum
* Deepak Lamba, Genentech
Moderator
Short Talks From Abstracts  
5:25–6:25 PM
 Fred Farr Forum
* Nan Hultgren, University of California, Los Angeles
Moderator
Douglas Vollrath, Stanford University School of Medicine
Short Talk: A Critical Role for RPE Coenzyme Q Oxidation in Outer Retinal Health
Cristhian J Ildefonso, University of Florida College of Medicine
Short Talk: Unraveling the Role of the Mitochondrial Common Deletion on RPE Function
Lindsey A Chew, Duke University
Short Talk: Truncated Complement Factor H (Y402) Gene Therapy Restores Complement Regulation in Multiple Organ Systems
Jessica D Gumerson, REGENXBIO
Short Talk: Suprachoroidal Delivery of a Novel Capsid Expressing a C5 Inhibitor as a Potential Treatment for Dry Age-Related Macular Degeneration
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:25–6:30 PM
 Fred Farr Forum
Banquet Dinner for Hotel Guests  
6:30–7:30 PM
 Crocker Dining Room
Poster Session 2  
7:30–9:30 PM
 Kiln
Friday, September 20, 2024
Breakfast for Hotel Guests  
7:30–9:00 AM
 Crocker Dining Room
Career Development: Exploring Research Paths and Possibilities in Academia, Industry, and Beyond  
9:00–10:00 AM
 Fred Farr Forum
* Claire M. Gelfman, CMG Consulting
Independent Consultant
Kathy Boesze Battaglia, University of Pennsylvania
Professor
Preeti Subramanian, BrightFocus Foundation
Director of Vision Science
Andrew Kocab, ONL Therapeutics, Inc.
Vice President, Research
Sun Young Lee, University of Southern California
Assistant Professor of Ophthalmology
Navigating your Professional Role(s): Overcoming Challenges and Discovering Solutions, Facing Barriers and Finding Allies  
10:00–11:00 AM
 Fred Farr Forum
* Aparna Lakkaraju, University of California, San Francisco
Professor
Robert Mullins, University of Iowa
Professor of Ophthalmology and Visual Sciences
Diane Bovenkamp, BrightFocus Foundation
Vice President of Scientific Affairs
Goldis Malek, Duke University
Professor
Sydney Williams, UCSF
Graduate Student
Checkout/Departure  
11:00–1:00 PM
 Social Hall
Lunch for Hotel Guests  
12:00–1:00 PM
 Crocker Dining Room

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