Joint with: Antibodies as Drugs: Innovative Formats, Design and Engineering
Drug Delivery to the Brain: Emerging Modalities
February 17-20, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
James Gorman, Stina Syvänen and Danica Stanimirovic (in memoriam)
In Person
On Demand
February 17-20, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
James Gorman, Stina Syvänen and Danica Stanimirovic (in memoriam)
Available Formats:
In Person
On Demand
Supported by the Directors' Fund
Available Formats: = In Person = On Demand
Booking Function
Monday, February 17, 2025
Fundraising
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, February 18, 2025
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Robert G. Thorne, Denali Therapeutics / University of Minnesota
Delivery of Therapeutics to CNS via Different Routes of Administration: An Overview of Applications, Advantages and Disadvantages
Delivery of Therapeutics to CNS via Different Routes of Administration: An Overview of Applications, Advantages and Disadvantages
Advances in RMT Delivery Targets and Modalities
9:00–11:15 AM
Meritxell Teixidó, Gate2Brain S.L.
Gate2Brain Shuttles, going Beyond the Transport of Small Molecules
Gate2Brain Shuttles, going Beyond the Transport of Small Molecules
James Gorman, Wyss Institute
A Platform of Distinct Brain Shuttles Binding Known and Novel Targets
A Platform of Distinct Brain Shuttles Binding Known and Novel Targets
Benjamin A Smith, Biogen
Building a Toolbox for Efficacious and Safe Delivery of a Variety of Biologics and Oligonucleotides to the CNS
Building a Toolbox for Efficacious and Safe Delivery of a Variety of Biologics and Oligonucleotides to the CNS
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
On Own for Lunch
11:15–5:00 PM
Poster Setup
11:15–1:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable (Joint)
3:30–4:30 PM
Coffee Available
4:30–5:00 PM
Advances in Brain Delivery of Gene Therapies With Viral Vectors
5:00–7:00 PM
Mathieu E. Nonnenmacher, Voyager Therapeutics
BBB Receptors for Enhanced Delivery of AAV to the CNS
BBB Receptors for Enhanced Delivery of AAV to the CNS
Shannon Mansuo Lu, AskBio
Strategy and Progress to Enhance AAV Delivery to the CNS
Strategy and Progress to Enhance AAV Delivery to the CNS
Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania
Selection of Delivery Approach in Gene Therapy for AD, LSD, HD and other CNS Diseases
Selection of Delivery Approach in Gene Therapy for AD, LSD, HD and other CNS Diseases
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
Modeling for Translation: In vitro to in vivo
8:00–11:00 AM
Anna Jezierski, National Research Council Canada & University of Ottawa
On-Chip and Bioprinted BBB Models for Evaluation of Protein and Cell-based Therapeutics
On-Chip and Bioprinted BBB Models for Evaluation of Protein and Cell-based Therapeutics
Stina Syvänen, Uppsala University
Linking Brain PK and PD Using in vivo Imaging
Linking Brain PK and PD Using in vivo Imaging
Fei Hua, Certara
Talk Title to be Announced
Talk Title to be Announced
Speaker to be to be Announced
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Workshop 1: Emerging Principles of Anti-TfR Shuttle Engineering
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Nanoparticle and Cell-Based Platforms for Cross-BBB Delivery
5:00–7:00 PM
Derrick Gibbings, University of Ottawa
Extracellular Vesicle Trafficking and Therapeutic Delivery into the CNS
Extracellular Vesicle Trafficking and Therapeutic Delivery into the CNS
Samir Mitragotri, Harvard University
A Back-Pack based Myeloid Cell Therapy for Multiple Sclerosis
A Back-Pack based Myeloid Cell Therapy for Multiple Sclerosis
Michael Mitchell, University of Pennsylvania
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood−Brain Barrier Transfection and Crossing
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood−Brain Barrier Transfection and Crossing
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, February 20, 2025
Breakfast
7:00–8:00 AM
Translational Studies and Representative Clinical Trials
8:00–11:00 AM
Luka Kulic, F. Hoffmann-La Roche Ltd.
Clinical Data on the Gantenerumab Shuttle
Clinical Data on the Gantenerumab Shuttle
Mathias Schmidt, JCR Pharma
Clinical Advancement and Measuring Efficacy of Biologics Crossing the Blood-Brain-Barrier
Clinical Advancement and Measuring Efficacy of Biologics Crossing the Blood-Brain-Barrier
Daniel Grant, Novartis Pharmaceuticals Corporation
Talk Title to be Announced
Talk Title to be Announced
Speaker to be to be Announced
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Workshop 2: Emerging Modalities and Future Opportunities in Targeted Brain Delivery
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
‘Tailoring’ Delivery to Disease Pathophysiology
5:00–7:00 PM
Christian Haass, Ludwig-Maximilians University Munich
TREM2-a Master Regulator of Neuroinflammation: From Target Biology to Targeted Therapy
TREM2-a Master Regulator of Neuroinflammation: From Target Biology to Targeted Therapy
Joy Yu Zuchero, Denali Therapeutics Inc
Transport Vehicle: Utilizing the Brain Vasculature to Delivery CNS Therapeutics
Transport Vehicle: Utilizing the Brain Vasculature to Delivery CNS Therapeutics
Speaker to be to be Announced
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–7:15 PM
Social Hour with Lite Bites
7:15–8:15 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Friday, February 21, 2025
Departure
12:00–11:59 PM
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