Joint with: B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics
T and B Cell Collaboration in Germinal Centers and Beyond
October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Shane Crotty, Michela Locci and Jennifer L. Gommerman
In Person
On Demand
October 1-4, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Shane Crotty, Michela Locci and Jennifer L. Gommerman
Available Formats:
In Person
On Demand
Supported by the Directors' Fund
Available Formats: = In Person = On Demand
Booking Function
Fundraising
Sunday, October 1, 2023
Arrival and Registration
9:00–1:00 PM
Grand Foyer
Welcome Mixer
11:00–1:00 PM
Grand Foyer
Monday, October 2, 2023
Breakfast
12:00–1:00 AM
Sea to Sky A
Welcoming Remarks and Keynote Session (Joint)
1:00–2:00 AM
Sea to Sky B/C
* Tullia C. Bruno, University of Pittsburgh
Session Chair
Session Chair
* Shane Crotty, La Jolla Institute for Immunology
Session Chair
Session Chair
* Michela Locci, University of Pennsylvania
Session Chair
Session Chair
Pamela L. Schwartzberg, NIAID, National Institutes of Health
Hyperactivated PI3Kd, in a Human Primary Immunodeficiency, Influences Tfh and Germinal Centers, Altering Self and Commensal Reactivity and Humoral Immunity
Hyperactivated PI3Kd, in a Human Primary Immunodeficiency, Influences Tfh and Germinal Centers, Altering Self and Commensal Reactivity and Humoral Immunity
Coffee Break
2:00–2:30 AM
Grand Foyer
Tfh Differentiation
2:30–4:15 AM
Sea to Sky C
* Michela Locci, University of Pennsylvania
Session Chair
Session Chair
* Di Yu, University of Queensland
Session Chair
Session Chair
Hongbo Chi, St. Jude Children's Research Hospital
Functional Genomics of Metabolic Control of Tfh Differentiation
Functional Genomics of Metabolic Control of Tfh Differentiation
Di Yu, University of Queensland
Regulation of Tfh Cells by Ferroptosis
Regulation of Tfh Cells by Ferroptosis
Jennifer A. Juno, University of Melbourne
Biogenesis and Recall of CD4 and cTFH Responses to Viral Infection and Vaccination
Biogenesis and Recall of CD4 and cTFH Responses to Viral Infection and Vaccination
Youn Soo Choi, Seoul National University College of Medicine
Short Talk: Transcription Factor Mef2d Functions as a Critical Rheostat to Control SAP- and IL-21-Dependent Humoral Immunity
Short Talk: Transcription Factor Mef2d Functions as a Critical Rheostat to Control SAP- and IL-21-Dependent Humoral Immunity
On Own for Lunch
4:15–10:00 AM
Poster Setup
4:15–6:00 AM
Sea to Sky A
Poster Viewing
6:00–3:00 PM
Sea to Sky A
Workshop 1: Tfh and GC B Cell Biology
7:30–9:30 AM
Sea to Sky C
* Andre Ballesteros Tato, The University of Alabama at Birmingham
Session Chair
Session Chair
* Joanna R. Groom, Walter and Eliza Hall Institute of Medical Research
Session Chair
Session Chair
Jungseo Choi, Seoul National University
Air Pollutants Induce an IgE-promoting Follicular Helper T Cell Subset Independently of CD301b+ DCs
Air Pollutants Induce an IgE-promoting Follicular Helper T Cell Subset Independently of CD301b+ DCs
Diana M Castaño, University of Pennsylvania and Universidad de Antioquia
IL-12 Drives the Differentiation of Human T Follicular Regulatory Cells
IL-12 Drives the Differentiation of Human T Follicular Regulatory Cells
Emily Siniscalco, Yale University
Layers of T Cell Redundancy in the Gut Enable Resilient Food-specific IgA Production
Layers of T Cell Redundancy in the Gut Enable Resilient Food-specific IgA Production
Juhee Pae, Rockefeller University
Tracking Germinal Center B Cell Cycling in vivo
Tracking Germinal Center B Cell Cycling in vivo
Katlyn Lederer, Perelman School of Medicine at the University of Pennsylvania
Early Stroma-driven Notch Signals are Required for T Follicular Helper Cell Differentiation and Germinal Center Responses to SARS-CoV-2 mRNA Vaccines
Early Stroma-driven Notch Signals are Required for T Follicular Helper Cell Differentiation and Germinal Center Responses to SARS-CoV-2 mRNA Vaccines
Dinis Pedro Calado, Francis Crick Institute
Regulation of BCR-mediated Ca2+ Mobilization by MIZ1-TIMBIM4 Safeguards IgG1+ GC B Cell Positive Selection
Regulation of BCR-mediated Ca2+ Mobilization by MIZ1-TIMBIM4 Safeguards IgG1+ GC B Cell Positive Selection
Andrew Cox, Cincinnati Children's Hospital Medical Center
Follicular Helper T Cells Lacking KLF2 are no Longer Susceptible to Natural Killer Cell Immunoregulation
Follicular Helper T Cells Lacking KLF2 are no Longer Susceptible to Natural Killer Cell Immunoregulation
Coffee Available
9:30–10:00 AM
Grand Foyer
Germinal Center Biology
10:00–12:00 PM
Sea to Sky C
* Amelia Escolano, Wistar Institute
Session Chair
Session Chair
* Oliver Bannard, University of Oxford
Session Chair
Session Chair
Gabriel D. Victora, Rockefeller University
Secondary Germinal Centers and Recall of Memory B Cells
Secondary Germinal Centers and Recall of Memory B Cells
Tomohiro Kurosaki, Osaka University
Regulation of Plasma Cell Egress from Secondary Lymphoid Tissues and its Retention in Bone Marrow
Regulation of Plasma Cell Egress from Secondary Lymphoid Tissues and its Retention in Bone Marrow
Oliver Bannard, University of Oxford
B Cell Selection in Germinal Centers
B Cell Selection in Germinal Centers
Zhoujie Ding, Monash University
Short Talk: Intrinsically Determined Turnover Underlies Broad Heterogeneity in Plasma-cell Lifespan
Short Talk: Intrinsically Determined Turnover Underlies Broad Heterogeneity in Plasma-cell Lifespan
Andre Ballesteros Tato, The University of Alabama at Birmingham
Short Talk: IFN-γ Production by Tfh Cells Control Lung Memory B Cell Responses to Influenza
Short Talk: IFN-γ Production by Tfh Cells Control Lung Memory B Cell Responses to Influenza
Social Hour with Lite Bites
12:00–1:00 PM
Sea to Sky A
Poster Session 1
12:30–3:00 PM
Sea to Sky A
Tuesday, October 3, 2023
Breakfast
12:00–1:00 AM
Sea to Sky A
T and B Cell Interactions in Tissues and TLS (Joint)
1:00–4:00 AM
Sea to Sky B/C
* Tullia C. Bruno, University of Pittsburgh
Session Chair
Session Chair
* Shane Crotty, La Jolla Institute for Immunology
Session Chair
Session Chair
Ziv Shulman, Weizmann Institute
Unexpected Tumor-Reactive Antibodies
Unexpected Tumor-Reactive Antibodies
Nikhil S. Joshi, Yale University School of Medicine
Neoantigen-Driven B Cell and CD4 T Follicular Helper Cell Collaboration Promotes Anti-Tumor CD8 T Cell
Neoantigen-Driven B Cell and CD4 T Follicular Helper Cell Collaboration Promotes Anti-Tumor CD8 T Cell
Jennifer L. Gommerman, University of Toronto
Meningeal Inflammation in Multiple Sclerosis – What are B Cells Doing?
Meningeal Inflammation in Multiple Sclerosis – What are B Cells Doing?
Shane Crotty, La Jolla Institute for Immunology
The Importance of Tfh and Germinal Centers in Regulating Immunodominance for Vaccines Against Challenging Targets
The Importance of Tfh and Germinal Centers in Regulating Immunodominance for Vaccines Against Challenging Targets
Inta Gribonika, National Allergy and Infectious Diseases
Short Talk: Microbiota Induced Humoral Immunity is Driven by Autonomous Skin-intrinsic Germinal Centers
Short Talk: Microbiota Induced Humoral Immunity is Driven by Autonomous Skin-intrinsic Germinal Centers
Ian MacFawn, University of Pittsburgh
Short Talk: The Activity of Tertiary Lymphoid Structures in High Grade Serous Ovarian Cancer is Governed by Site, Stroma, and Cellular Interactions
Short Talk: The Activity of Tertiary Lymphoid Structures in High Grade Serous Ovarian Cancer is Governed by Site, Stroma, and Cellular Interactions
Coffee Break
2:00–2:20 AM
Grand Foyer
On Own for Lunch
4:00–10:00 AM
Poster Setup
4:00–6:00 AM
Sea to Sky A
Poster Viewing
6:00–3:00 PM
Sea to Sky A
Career Roundtable (Joint)
7:30–9:30 AM
Tyler J. Curiel, Dartmouth College
Professor of Medicine
Professor of Medicine
Hong I. Wan, Tallac Therapeutics
President, Chief Executive Officer and Co-Founder
President, Chief Executive Officer and Co-Founder
Dinis Pedro Calado, Francis Crick Institute
Senior Group Leader
Senior Group Leader
Myong-Hee Mia Sung, NIH
Earl Stadtman Investigator & Chief, Transcription Systems Dynamics and Biology Unit
Earl Stadtman Investigator & Chief, Transcription Systems Dynamics and Biology Unit
Coffee Available
9:30–10:00 AM
Grand Foyer
T:B Interactions in Infectious Diseases and Vaccines
10:00–12:00 PM
Sea to Sky C
* Robert Abbott, University of Texas Medical Branch
Session Chair
Session Chair
* Lucy S. K. Walker, University College London
Session Chair
Session Chair
Ali H. Ellebedy, Washington University School of Medicine
Germinal Center Responses to COVID-19 and Influenza Vaccination in Humans
Germinal Center Responses to COVID-19 and Influenza Vaccination in Humans
Lucy S. K. Walker, University College London
The CTLA-4-IL-21 Axis in the Regulation of T Cell / B Cell Collaboration
The CTLA-4-IL-21 Axis in the Regulation of T Cell / B Cell Collaboration
Michela Locci, University of Pennsylvania
Mechanisms of Germinal Center Induction by mRNA Vaccines
Mechanisms of Germinal Center Induction by mRNA Vaccines
Sydney Ramirez, LJI
Short Talk: Longitudinal Tracking of Upper Respiratory Tract Germinal Center Populations
Short Talk: Longitudinal Tracking of Upper Respiratory Tract Germinal Center Populations
Nimesh Gupta, National Institute of Immunology
Short Talk: Distinct Features of a Peripheral T Helper Subset that Majorly Drives the B Cell Response in Dengue
Short Talk: Distinct Features of a Peripheral T Helper Subset that Majorly Drives the B Cell Response in Dengue
Social Hour with Lite Bites
12:00–1:00 PM
Sea to Sky A
Poster Session 2
12:30–3:00 PM
Sea to Sky A
Wednesday, October 4, 2023
Breakfast
12:00–1:00 AM
Sea to Sky A
Regulation of T:B Interactions
1:00–4:00 AM
Sea to Sky C
* Marion Pepper, University of Washington
Session Chair
Session Chair
* Kai-Michael Toellner, University of Birmingham
Session Chair
Session Chair
Steven F. Ziegler, Benaroya Research Institute
B Cell– and T Cell–intrinsic Regulation of Germinal Centers by Thymic Stromal Lymphopoietin
B Cell– and T Cell–intrinsic Regulation of Germinal Centers by Thymic Stromal Lymphopoietin
Marion Pepper, University of Washington
IL-4 Downregulates BCL6 to Promote Memory B Cell Selection in Germinal Centers
IL-4 Downregulates BCL6 to Promote Memory B Cell Selection in Germinal Centers
Bo Liu, Tsinghua University
Short Talk: B Cell-reactive Triad of B Cells, Follicular Helper and Regulatory T Cells at Homeostasis
Short Talk: B Cell-reactive Triad of B Cells, Follicular Helper and Regulatory T Cells at Homeostasis
Alexandra R Dvorscek, Monash University
Short Talk: T Cell-dependent B Cell Responses are Shaped by the Amount, Affinity and Specificity of Antigen-specific Antibody
Short Talk: T Cell-dependent B Cell Responses are Shaped by the Amount, Affinity and Specificity of Antigen-specific Antibody
Kai-Michael Toellner, University of Birmingham
Short Talk: Recycling of Memory B Cells Between Germinal Center and Lymph Node Subcapsular Sinus Supports Affinity Maturation to Antigenic Drift
Short Talk: Recycling of Memory B Cells Between Germinal Center and Lymph Node Subcapsular Sinus Supports Affinity Maturation to Antigenic Drift
Julia Eve Merkenschlager, Rockefeller University
Short Talk: Dynamic Regulation of T Follicular Cells throughout Time in the GC Space
Short Talk: Dynamic Regulation of T Follicular Cells throughout Time in the GC Space
Carola G. Vinuesa, Francis Crick Institute
Remote Presentation: Novel Human TLR7 Mutations cause Human Lupus and Impact both Germinal Center B Cells and Helper T Cells
Remote Presentation: Novel Human TLR7 Mutations cause Human Lupus and Impact both Germinal Center B Cells and Helper T Cells
Coffee Break
2:00–2:20 AM
Grand Foyer
On Own for Lunch
4:00–10:00 AM
Poster Setup
4:00–6:00 AM
Sea to Sky A
Poster Viewing
6:00–3:00 PM
Sea to Sky A
Workshop 2: T:B Interactions in Disease States
7:30–9:30 AM
Sea to Sky C
* Jason G. Cyster, HHMI/University of California, San Francisco
Session Chair
Session Chair
* Joshua F.E. Koenig, McMaster University
Session Chair
Session Chair
Joshua F.E. Koenig, McMaster University
A Distinct Phenotype of Polarized Memory B Cell Holds IgE Memory
A Distinct Phenotype of Polarized Memory B Cell Holds IgE Memory
Courtney McDougal, University of Washington
Plasmodium-specific Memory B Cells Generated in the Absence of Germinal Centers are Biased Towards High Avidity Epitopes and have Limited Ability to Self-renew
Plasmodium-specific Memory B Cells Generated in the Absence of Germinal Centers are Biased Towards High Avidity Epitopes and have Limited Ability to Self-renew
Nathan Bracey, Stanford
The Dynamics of TCR Specificity Groups Between Secondary Lymphoid Organs and the Periphery Reveal Mechanisms of Age-associated Immune Dysfunction
The Dynamics of TCR Specificity Groups Between Secondary Lymphoid Organs and the Periphery Reveal Mechanisms of Age-associated Immune Dysfunction
Jia Le Lee, Babraham Institute, Babraham Research Campus
B Cell-intrinsic Changes with Age do not Impair B Cell Responses to Immunisation
B Cell-intrinsic Changes with Age do not Impair B Cell Responses to Immunisation
Tiago Abreu Mota, University of Basel
Arenavirus Cross-reactive Memory B Cells Afford Protection against Lassa Virus Infection
Arenavirus Cross-reactive Memory B Cells Afford Protection against Lassa Virus Infection
Jonathan A. Lagos Orellana, Seattle Children's Research Institute
Role of B Cell Adapter for PI-3 Kinase (BCAP) in Antigen Internalization and Processing
Role of B Cell Adapter for PI-3 Kinase (BCAP) in Antigen Internalization and Processing
Ragan A. Pitner, University of Washington
Blunting Specific T-dependent Antibody Responses by Exploiting Affinity Selection with Engineered 'Decoy' Exogenous B Cells
Blunting Specific T-dependent Antibody Responses by Exploiting Affinity Selection with Engineered 'Decoy' Exogenous B Cells
Coffee Available
9:30–10:00 AM
Grand Foyer
T:B Biology in Lungs, Gut, and Nonlymphoid Organs
10:00–11:45 AM
Sea to Sky C
* Jennifer L. Gommerman, University of Toronto
Session Chair
Session Chair
* Andrea Reboldi, University of Massachusetts Chan Medical School
Session Chair
Session Chair
Hai Qi, Tsinghua University
T-B Interactions and B-Cell Memory
T-B Interactions and B-Cell Memory
Troy D. Randall, University of Alabama at Birmingham
Establishment of Resident Memory B Cells in the Lung, and the Potential of Intranasal Vaccines
Establishment of Resident Memory B Cells in the Lung, and the Potential of Intranasal Vaccines
Carla R. Nowosad, New York University
Germinal Center B Cell Dynamics in the Gut
Germinal Center B Cell Dynamics in the Gut
Andrea Reboldi, University of Massachusetts Chan Medical School
Short Talk: Divergent Intracellular Nutrient Sensing Pathways Modulate Plasma Cell Function
Short Talk: Divergent Intracellular Nutrient Sensing Pathways Modulate Plasma Cell Function
Closing Keynote Address
11:45–12:30 PM
Sea to Sky C
* Jennifer L. Gommerman, University of Toronto
Session Chair
Session Chair
Jason G. Cyster, HHMI/University of California, San Francisco
Mast Cells Help Organize Peyer’s Patch Niche for Induction of IgA Responses
Mast Cells Help Organize Peyer’s Patch Niche for Induction of IgA Responses
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
12:30–12:45 PM
Sea to Sky C
Social Hour with Lite Bites
12:45–1:30 PM
Sea to Sky A
Poster Session 3
12:45–3:00 PM
Sea to Sky A
Cash Bar
1:00–3:00 PM
Sea to Sky A
Thursday, October 5, 2023
Departure
12:00–4:59 PM
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