Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches
February 16-19, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:
Philip Chamberlain and Fleur M. Ferguson
In Person
On Demand
February 16-19, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:
Philip Chamberlain and Fleur M. Ferguson
Available Formats:
In Person
On Demand
Supported by the Directors' Fund
Available Formats: = In Person = On Demand
Booking Function
Sunday, February 16, 2025
Fundraising
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Monday, February 17, 2025
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Benjamin F. Cravatt III, The Scripps Research Institute
Talk Title to be Announced
Talk Title to be Announced
Molecular and Structural Biology of Induced Proximity Drugs
9:00–11:15 AM
Brenda A. Schulman, Max Planck Institute of Biochemistry
E3-Ligase Activation, Regulation and Structure
E3-Ligase Activation, Regulation and Structure
Benjamin L. Ebert, Dana-Farber Cancer Institute
New TPD Mechanisms from Functional Genomics
New TPD Mechanisms from Functional Genomics
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
On Own for Lunch
11:15–5:00 PM
Poster Setup
11:15–1:00 PM
Poster Viewing
1:00–10:00 PM
Workshop 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
New Induced Proximity Approaches
5:00–7:00 PM
Gerald R. Crabtree, Stanford University
Rewiring Cancer Drivers to Activate Programmed Cell Death Pathways
Rewiring Cancer Drivers to Activate Programmed Cell Death Pathways
Xin Zhou, Dana-Farber Cancer Institute
Novel Bifunctional Antibodies for Targeted Membrane Protein Degradation
Novel Bifunctional Antibodies for Targeted Membrane Protein Degradation
Kevan M. Shokat, University of California, San Francisco
Proximity Approaches to Hijack Immune Signaling and Recognition
Proximity Approaches to Hijack Immune Signaling and Recognition
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Tuesday, February 18, 2025
Breakfast
7:00–8:00 AM
Innovation in Induced Proximity Drug Discovery
8:00–11:00 AM
William C. Forrester, Novartis
The Novartis Targeted Protein Degradation Platform
The Novartis Targeted Protein Degradation Platform
Fleur M. Ferguson, University of California, San Diego
Interrogating the Druggable Proteome with Proximity Pharmacology
Interrogating the Druggable Proteome with Proximity Pharmacology
Philip Chamberlain, Neomorph, Inc.
Talk Title to be Announced
Talk Title to be Announced
Anil Vasudevan, AbbVie, Inc.
The Hunt for Ligands for Tissue-Restricted Ligases
The Hunt for Ligands for Tissue-Restricted Ligases
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Poster Setup
11:00–1:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Clinical Progress in Proximity Technologies
5:00–7:00 PM
Danette L. Daniels, Foghorn Therapeutics, Inc
Clinical Progress in Degrading Epigenetic Disease Drivers
Clinical Progress in Degrading Epigenetic Disease Drivers
Michael Pourdehnad, Bristol-Myers Squibb
Clinical Advances in Cereblon-based Heterobifunctional and Glue Degraders
Clinical Advances in Cereblon-based Heterobifunctional and Glue Degraders
Juliet Williams, Kymera Therapeutics
Clinical Updates on PROTACS in Immunology and Oncology
Clinical Updates on PROTACS in Immunology and Oncology
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
Beyond Degradation: New Applications of Induced Proximity
8:00–11:00 AM
Cristina Mayor-Ruiz, IRB Barcelona
Chasing Molecular Glue Degraders
Chasing Molecular Glue Degraders
Amit Choudhary, Harvard Medical School
Talk Title to be Announced
Talk Title to be Announced
Michelle R. Arkin, University of California, San Francisco
Hacking Native Protein-Protein Interaction Networks with Molecular Glues
Hacking Native Protein-Protein Interaction Networks with Molecular Glues
Francesca Ester Morreale, Francis Crick Institute
Enabling Targeted Protein Degradation in Bacteria
Enabling Targeted Protein Degradation in Bacteria
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Workshop 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Hijacking New Components of the Degradation Machinery
5:00–7:00 PM
Stefan Knapp, SGC Frankfurt
E3-Ligases and updates from the SGC
E3-Ligases and updates from the SGC
Natalie Scholes, CeMM Research Center for Molecular Medicine
When Inhibitors Act as Degraders: Supercharging Protein Turnover via Endogenous Degradation Routes
When Inhibitors Act as Degraders: Supercharging Protein Turnover via Endogenous Degradation Routes
Daniel K. Nomura, University of California, Berkeley
Covalent Ligands to Drive Proximity
Covalent Ligands to Drive Proximity
Henry M. Colecraft, Columbia University
Hacking the Polyubiquitin Code to Understand and Manipulate Ion Channel Functional Expression
Hacking the Polyubiquitin Code to Understand and Manipulate Ion Channel Functional Expression
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Social Hour with Lite Bites
7:00–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Thursday, February 20, 2025
Departure
12:00–11:59 PM
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