Autoimmunity & Autoinflammation: Translating Basic Mechanisms into Novel Therapeutic Approaches

January 19-22, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Virginia Pascual, Raphaela Theresia Goldbach-Mansky, Veit Hornung and Richard M. Siegel

  In Person
  On Demand

January 19-22, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Virginia Pascual, Raphaela Theresia Goldbach-Mansky, Veit Hornung and Richard M. Siegel

Available Formats:   = In Person     = On Demand
Monday, January 19, 2026
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, January 20, 2026
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Jenny P.Y. Ting †, University of North Carolina at Chapel Hill
A 360° View of the Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
Autoimmunity and Autoinflammation: The Nucleic Acid Sensing Perspective
9:00–11:15 AM
Veit Hornung, Ludwig-Maximilians-University Munich
Recognition of Non-Self RNA by the Innate Immune System
Andrea Ablasser †, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING in Aging-Related Inflammation and Neurodegeneration
Michael Crackower †, Ventus Therapeutics
Novel Therapies to Target cGAS-STING
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
On Own for Lunch
11:15–5:00 PM
Poster Setup
11:15–1:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Coffee Available
4:30–5:00 PM
Inflammasomes: From Basic Mechanisms to Autoinflammatory Diseases
5:00–7:00 PM
Franklin Zhong †, NTU LKC School of Medicine
The NLRP1 Inflammasome
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health
Novel Mechanisms in Autoinflammatory Diseases
Nick Clarke †, NodThera
An Update on Inflammasome Targeting
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, January 21, 2026
Breakfast
7:00–8:00 AM
Innate Immune Cell Dysregulation in Autoimmune and AutoInflammatory Diseases
8:00–11:00 AM
Musa M. Mhlanga †, Radboud Institute for Molecular Life Sciences
The Intersection of Epigenetics and Metabolism in Trained Immunity
Virginia Pascual, Cornell University
Innate Immunity Dysregulation in Human Lupus
Brian Kim †, Mount Sinai
Innate Immune Regulation of Dermatitis
Kate L. Jeffrey †, Moderna and Harvard Medical School
Epigenetic Targeting of Innate Immune-Mediated Inflammation
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Poster Setup
11:00–1:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Adaptive Immune Cell Dysregulation in Autoimmune and Autoinflammatory Diseases
5:00–7:00 PM
Francisco J. Quintana †, Harvard Medical School and the Broad Institute of MIT and Harvard
Disease-Associated Astrocyte Epigenetic Memory Promotes CNS Pathology
Carola G. Vinuesa †, Francis Crick Institute
Preclinical Models of Human Monogenic Autoimmunity
Aimee S. Payne †, Columbia University
Precision Targeting of Autoantigen-Specific B Cells in Myasthenia Gravis
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, January 22, 2026
Breakfast
7:00–8:00 AM
Stromal Cells in Autoinflammation and Autoimmunity: From Basic Mechanisms to Precision Medicine
8:00–11:00 AM
Prisca Liberali †, Friedrich Miescher Institute for Biomedical Research
Collective Behaviors in Organoids
Michael B. Brenner †, Harvard Medical School
Adipocyte and Fibroblast Dysfunction in Inflammatory Diseases
Ken H. Cadwell †, University of Pennsylvania
Patient-Derived Intestinal Organoids to Predict and Identify Individual Responsiveness to Therapy in UC
Kara Lassen †, Roche
Patient Stratification Towards Precision Medicine in IBD
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Coffee Available
4:30–5:00 PM
Novel Disease Insights and Therapies: Lessons from Tissue Profiling
5:00–6:45 PM
Tobias Lanz †, Stanford University
Roadmap for Understanding Mechanisms on how Epstein-Barr Virus Triggers Multiple Sclerosis and for Translating these Discoveries in Clinical Trials
Shruti Naik †, Icahn School of Medicine at Mount Sinai
Spatial Transcriptomics to Stratify Psoriatic Disease Severity
Richard M. Siegel, Novartis Institutes of BioMedical Research
Novel Approaches to Tissue B Cell Depletion in Autoimmune Diseases
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Social Hour with Lite Bites
7:00–8:00 PM
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Friday, January 23, 2026
Departure
12:00–11:59 PM

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