Joint with: Neurodegeneration: Linking Cellular Pathways to Therapeutic Strategies
Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology
Jun 08–11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Dorothy Schafer, Asya Rolls and Anne Schaefer
Jun 08–11, 2025 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Dorothy Schafer, Asya Rolls and Anne Schaefer
Available Formats:
Supported by:
Livestream
In Person
On Demand
Available Formats: = Livestream = In Person = On Demand
Merchandise Options
Registration Options
Sunday, June 8, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
Grand Foyer
Welcome Mixer
6:00–8:00 PM
Grand Foyer
Monday, June 9, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Sea to Sky B/C
Catherine G. Dulac, Harvard University
Neural-Immune and Regulation of Whole-Body Physiology in Health and Disease
Neural-Immune and Regulation of Whole-Body Physiology in Health and Disease
Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
Coffee Break
9:30–9:50 AM
Grand Foyer
Cell Biology of Neuroinflammation within Diseased Brain Circuits (Joint)
10:00–11:30 AM
Sea to Sky B/C
Veronique Miron, University of Toronto
Immune Regulation of Remyelination in Multiple Sclerosis
Immune Regulation of Remyelination in Multiple Sclerosis
Timothy Hammond, Sanofi
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
Aaron DiAntonio, Washington University in St. Louis
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
Poster Setup
11:15–1:00 PM
Sea to Sky A
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Sea to Sky A
Symposia Spotlight 1: The Digital Era in Neurodegeneration and Neuroinflammation (Joint)
2:30–4:30 PM
Sea to Sky B/C
Max Salick †, Insitro
Genomics, and Machine Learning to Uncover Neurological Disease Mechanisms and Therapeutic Targets
Genomics, and Machine Learning to Uncover Neurological Disease Mechanisms and Therapeutic Targets
Camille Januel †, Chan Zuckerberg Biohub San Francisco
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
Carmen Sandoval-Espinosa †, Genentech
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
Zinan Zhou, Boston Children's Hospital
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
Coffee Available
4:30–5:00 PM
Grand Foyer
Neural-Immune Signaling Intrinsic to Brain Circuits
5:00–7:00 PM
Sea to Sky B
Anne Schaefer, Icahn School of Medicine at Mount Sinai, MPI Ageing
The Operational Principles of Neuron-Microglia Circuits
The Operational Principles of Neuron-Microglia Circuits
Ádám Dénes, Hungarian Academy of Sciences
Microglia Control Circuit Homeostasis and Pathological States
Microglia Control Circuit Homeostasis and Pathological States
Dorothy Schafer, University of Massachusetts Chan Medical School
Neural-Immune Signaling Governing Microglia Function Within Brain Circuits
Neural-Immune Signaling Governing Microglia Function Within Brain Circuits
Baljit S. Khakh, David Geffen School of Medicine, UCLA
Astrocyte Control of Neural Circuits During Inflammation
Astrocyte Control of Neural Circuits During Inflammation
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Poster Session 1
7:30–10:00 PM
Sea to Sky A
Tuesday, June 10, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Mechanisms of Aging in Neuroinflammation and Neurodegeneration (Joint)
8:00–11:00 AM
Sea to Sky B/C
Robin Franklin, Altos Labs
The Impact of Aging on Remyelination Potential in the Inflamed Brain
The Impact of Aging on Remyelination Potential in the Inflamed Brain
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Role of cGAS/Sting in Neurodegenerative Diseases
Role of cGAS/Sting in Neurodegenerative Diseases
Judith Frydman, Stanford University
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
Oliver Hahn, Calico Life Sciences LLC
Short Talk: Heterochronic Myeloid Cell Replacement Reveals Local Brain Environment as the Key Driver of Microglia Aging
Short Talk: Heterochronic Myeloid Cell Replacement Reveals Local Brain Environment as the Key Driver of Microglia Aging
Ian Guldner †, Stanford University
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
Vanessa Martin †, University of California, San Diego
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
Wei Jing Chong †, Nanyang Technological University
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
Coffee Break
9:00–9:20 AM
Grand Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Sea to Sky B/C
Poster Setup
11:00–1:00 PM
Sea to Sky A
On Own for Lunch
11:00–3:30 PM
Poster Viewing
1:00–10:00 PM
Sea to Sky A
Career Roundtable (Joint)
2:15–3:15 PM
Sea to Sky B
Meet the Editors
3:30–4:30 PM
Sea to Sky B
Coffee Available
4:30–5:00 PM
Grand Foyer
Neural Circuit Control of Immunity
5:00–7:00 PM
Sea to Sky B
Asya Rolls, Tel Aviv University
Immunoception- Neuronal Representation of Immune Processes to Modulate Behavior
Immunoception- Neuronal Representation of Immune Processes to Modulate Behavior
Erica K Sloan, Monash University
Stress-Induced Regulation of Immune System Function
Stress-Induced Regulation of Immune System Function
Isaac Chiu, Harvard Medical School
Neural Control of the Peripheral Immune Response
Neural Control of the Peripheral Immune Response
Michelle Swarovski †, University of Utah
Short Talk: Uncovering the Role of Circumventricular Organs During Infection
Short Talk: Uncovering the Role of Circumventricular Organs During Infection
Pailin Chiaranunt †, UCSF
Short Talk: Investigating the Role of Interferon Signaling on Vagal Neurons During Influenza Infection
Short Talk: Investigating the Role of Interferon Signaling on Vagal Neurons During Influenza Infection
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Poster Session 2
7:30–10:00 PM
Sea to Sky A
Wednesday, June 11, 2025
Breakfast
7:00–8:00 AM
Sea to Sky A
Neural-Immune Regulation of Peripheral Organ Homeostasis
8:00–11:00 AM
Sea to Sky B
Jens C. Brüning, Max Planck Institute for Metabolism Research
Neural Control of Age-Related Metabolic Dysfunction
Neural Control of Age-Related Metabolic Dysfunction
Ivan E. de Araujo, Max Planck Institute for Biological Cybernetics
Neural Networks Controlling Peripheral Organ Function
Neural Networks Controlling Peripheral Organ Function
Ana Domingos, University of Oxford
Neuroimmune Control of Obesity
Neuroimmune Control of Obesity
Sravya Kurapati †, University of Massachusetts Chan Medical School
Short Talk: Monocytes Mobilized by Enteric Neurons Remodel the Enteric Nervous System
Short Talk: Monocytes Mobilized by Enteric Neurons Remodel the Enteric Nervous System
Kartik Rajagopalan, UT Southwestern Medical Center
Short Talk: Leptin Signaling Maintains Autonomic Stability During Severe Influenza Infection in Mice
Short Talk: Leptin Signaling Maintains Autonomic Stability During Severe Influenza Infection in Mice
Mitre Athaiya †, University of Michigan
Short Talk: The Role of Macrophage Metabolic Reprogramming in Peripheral Nervous System Regeneration and Development of Neuropathic Pain
Short Talk: The Role of Macrophage Metabolic Reprogramming in Peripheral Nervous System Regeneration and Development of Neuropathic Pain
Jaewon Sim, Michigan State University
Short Talk: Monocyte-derived IL-10 Drives Sex Difference in Pain Duration
Short Talk: Monocyte-derived IL-10 Drives Sex Difference in Pain Duration
Coffee Break
9:00–9:20 AM
Grand Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Sea to Sky B
Irene Sanchez Martin †, Cold Spring Harbor Laboratory
Maternal Immune Activation Reveals Male-Specific Sensitivity to Inflammation-Driven Deficits in Fetal Development
Maternal Immune Activation Reveals Male-Specific Sensitivity to Inflammation-Driven Deficits in Fetal Development
Annie Ciernia, University of British Columbia
Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Microglia Axis
Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Microglia Axis
Caroline L Wee, A*STAR Institute of Molecular and Cell Biology
A Gut-Immune-Brain Circuit Links Diet-Induced Microbial Dysbiosis to Sleep Disruption
A Gut-Immune-Brain Circuit Links Diet-Induced Microbial Dysbiosis to Sleep Disruption
Abi G Yates, Icahn School of Medicine at Mount Sinai
Astrocyte Precursor Cells Instruct Microglial Programming Via IL-3 For Neuronal Sculpting And Social Development
Astrocyte Precursor Cells Instruct Microglial Programming Via IL-3 For Neuronal Sculpting And Social Development
Ugur Akcan †, Columbia Univeristy
The Transcription Factor RXRɑ, Regulates the Disease-Associated Gene Signatures of Myeloid Cells in Immune-Mediated OCD
The Transcription Factor RXRɑ, Regulates the Disease-Associated Gene Signatures of Myeloid Cells in Immune-Mediated OCD
Okito Hashimoto †, Feinstein Institute for Medical Research
A Subset of Neurons in the Bed Nuclei of the Stria Terminalis (BNST) Controls IL1-β - Mediated Stress Responses
A Subset of Neurons in the Bed Nuclei of the Stria Terminalis (BNST) Controls IL1-β - Mediated Stress Responses
Bradley J Cutler, The Ohio State University
Neuro-Immune Signaling Underlying Behavioral Fever in Larval Zebrafish
Neuro-Immune Signaling Underlying Behavioral Fever in Larval Zebrafish
Nannan Lu †, Stanford University
Exploring the Interaction between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication
Exploring the Interaction between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication
Coffee Available
4:30–5:00 PM
Grand Foyer
Immune System Control of Behavior
5:00–6:45 PM
Sea to Sky B
Maayan Levy, University of Pennsylvania
Understanding the Bi-Directional Communication Between the Gut and the Brain
Understanding the Bi-Directional Communication Between the Gut and the Brain
Richard Daneman, University of California, San Diego
The Brain Vasculature: A Conduit between the Periphery and Control of Brain Circuits
The Brain Vasculature: A Conduit between the Periphery and Control of Brain Circuits
Jonathan Kipnis, Washington University School of Medicine
Immune Environment in Brain Borders Governing Circuit Function and Behavior
Immune Environment in Brain Borders Governing Circuit Function and Behavior
Shelly A Buffington †, Baylor College of Medicine
Short Talk: Protozoan Parasite Disrupts Intestinal Immunity in Pregnancy, Thalamocortical Activity in Offspring
Short Talk: Protozoan Parasite Disrupts Intestinal Immunity in Pregnancy, Thalamocortical Activity in Offspring
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Sea to Sky B
Social Hour with Lite Bites
7:00–8:00 PM
Sea to Sky A
Trivia!
8:00–9:00 PM
Thursday, June 12, 2025
Departure
12:00–11:59 PM
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