Joint with: Machine Learning Applied to Macromolecular Structure and Function
Imaging Biomolecules Across Scales: From Atoms to Tissues

Mar 23–26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Elizabeth Villa, Bridget Carragher and Ilaria Testa

  In Person
  On Demand

Mar 23–26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Elizabeth Villa, Bridget Carragher and Ilaria Testa

Supported by:
Available Formats:   = In Person     = On Demand
Sunday, March 23, 2025
Registration
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer
6:00–8:00 PM
 Longs Peak Foyer
Monday, March 24, 2025
Breakfast
7:00–8:00 AM
 Quandary Peak
Welcome and Keynote Address (Joint)
8:00–9:00 AM
 Longs Peak
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry
Cryo-Electron Tomography or the Power of Seeing the Whole Picture
Machine Learning for Protein Structure (Joint)
9:00–11:30 AM
 Longs Peak
Hannah Wayment-Steele, University of Wisconsin-Madison
Have Protein Language Models Learned Dynamics
Sergey Ovchinnikov, Massachusetts Institute of Technology
Hacking AlphaFold to Do New Things
Mohammed AlQuraishi, Columbia University
Understanding How AlphaFold Learns
Fabian C Spoendlin, University of Oxford
Short Talk: Predicting the Conformational Flexibility of Antibody and T-cell Receptor CDRs
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
 Longs Peak Foyer
Poster Setup
11:30–1:00 PM
 Quandary Peak
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
 Quandary Peak
Symposia Spotlight 1: Orthogonal Technologies
2:30–4:30 PM
 Longs Peak
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Longs Peak Foyer
Structure Determination of Challenging Complexes in vitro and in situ
5:00–7:00 PM
 Longs Peak
Lori A Passmore, MRC Laboratory of Molecular Biology
Mechanistic Insight into Polyadenylation of Eukaryotic mRNAs
Dimitry Tegunov, Genentech
Enabling High-Resolution Structure Determination In Situ
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
 Quandary Peak
Poster Session 1
7:30–10:00 PM
 Quandary Peak
Tuesday, March 25, 2025
Breakfast
7:00–8:00 AM
 Quandary Peak
CryoET/EM and Machine Learning (Joint)
8:00–11:00 AM
 Longs Peak
Bridget Carragher, Chan Zuckerberg Imaging Institute
Tools and Technologies for Accelerating cryoET
Bronwyn A Lucas, University of California Berkeley
Single Molecule Localization and Structure Probing in Cells
Elizabeth Villa, University of California, San Diego
Discovering New Biology with Cryo-ET
Elizabeth Kellogg, St. Jude Children's Research Hospital
Structural Insights into CRISPR-Based Genome Editing
Short Talk(s) Chosen from Abstracts
Jonathan Schwartz †, Chan Zuckerberg Imaging Institute
Short Talk: Advancing Particle Identification In Cryo-Electron Tomograms With Deep Learning
Coffee Break
9:00–9:20 AM
 Longs Peak Foyer
Poster Setup
11:00–1:00 PM
 Quandary Peak
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
 Quandary Peak
Career Roundtable (Joint)
3:00–4:30 PM
 Torreys Peak
Coffee Available
4:30–5:00 PM
 Longs Peak Foyer
The Big Picture: Capturing Events with Large-Volume EM and CLEM
5:00–7:00 PM
 Longs Peak
Speaker to be Announced
Talk Title to be Announced
Virginie Hamel, University of Geneva
Unveiling the Architecture of the Cell by Combining cryoET and Ultrastructure Expansion Microscopy
Adam Frost, Altos Labs
ESCRT-III Machines and Organelle Homeostasis: In Vitro Versus In Situ
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
 Quandary Peak
Poster Session 2
7:30–10:00 PM
 Quandary Peak
Wednesday, March 26, 2025
Breakfast
7:00–8:00 AM
 Quandary Peak
Light Microscopy Comes to Structure
8:00–11:00 AM
 Longs Peak
Eric Mulhall, The Scripps Research Institute
Linking the Structure, Mechanics, and Function of PIEZO Ion Channels with Fluorescence Nanoscopy
Joerg Bewersdorf, Yale University
All-Optical Super-Resolution Imaging of Molecules in Their Nanoscale Cellular Context
Francisco Balzarotti, Research Institute for Molecular Pathology
Accessing the Nanoscale with Light Microscopy
Peter Dahlberg, Stanford University
Correlating Cryogenic Light and Electron Microscopy at the Nanoscale
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Longs Peak Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Technological Breakthroughs
2:30–4:30 PM
 Longs Peak
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Longs Peak Foyer
Bringing Molecules to Life with Live Cell Imaging at High Resolution
5:00–6:45 PM
 Longs Peak
Ilaria Testa, KTH Royal Institute of Technology
From Cells to STARSS: Monitoring the Life of Proteins at the Nanoscale
Suliana Manley,  École Polytechnique Fédérale de Lausanne
Mitochondrial Dynamic and Structural States Underpinning Homeostasis
Ralf Jungmann, Max Planck Institute of Biochemistry
DNA-PAINTs, SOMAmers and Ultra-Resolution Fluorescence Localizomics of DNA, RNA and Protein Interactions
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
 Longs Peak
Social Hour with Lite Bites
7:00–8:00 PM
 Quandary Peak
Entertainment
8:00–9:00 PM
 Torreys Peak
Cash Bar
8:00–9:00 PM
 Quandary Peak
Thursday, March 27, 2025
Departure
12:00–11:59 PM

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