Metabolic and Nutritional Control of Development and Cell Fate

May 07–09, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Lydia Finley and Ralph J. DeBerardinis

  In Person
  On Demand

May 07–09, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Lydia Finley and Ralph J. DeBerardinis

Supported by the  Directors' Fund
Available Formats:   = In Person     = On Demand
Wednesday, May 7, 2025
Registration
4:00–8:00 PM
 Conference Center Atrium
Welcome Mixer
6:00–8:00 PM
 Conference Center Atrium
Thursday, May 8, 2025
Breakfast
7:30–8:30 AM
 Beverly Foyer
Poster Setup
8:00–8:30 AM
 Ipswich
Poster Viewing
8:15–3:30 PM
 Ipswich
Welcome and Keynote Address
8:30–9:30 AM
 Beverly Room
Navdeep S Chandel, Northwestern University
Mitochondrial Signals to Developmental Networks
Metabolic Control of Cell Fate
9:30–11:30 AM
 Beverly Room
Lydia Finley, Memorial Sloan Kettering Cancer Center
Identifying Mechanisms Linking Metabolites to Cell Fate Control
Sean J. Morrison, University of Texas Southwestern Medical Center
Metabolic Regulation of Hematopoiesis
Martin A Estermann, NIEHS
Short Talk: O-GlcNAcylation in the Testis: A Key Metabolic Mechanism for Male Fertility
Juan Manuel Schvartzman, Columbia University
Short Talk: Polyamines Regulate Cell Fate by Altering the Accessibility of Histone Tails
Coffee Break
10:00–10:20 AM
 Beverly Foyer
Lunch
11:30–12:30 PM
 Newburyport
Poster Session 1
12:00–2:15 PM
 Ipswich
Symposia Spotlight: Redox Control of Developmental Pathways
2:15–3:30 PM
 Beverly Room
Zoe F Mann, King's College London
Metabolic 'Tuning' of Hair Cells Along the Tonotopic Axis of the Developing Cochlea
Elaine Fuchs, Rockefeller University
Optimizing Tissue Fitness in the Face of Metabolic Stress
Masayuki Yazawa, Icahn School of Medicine at Mount Sinai
Pyruvate and Lactate Imaging in Stem Cells
Marc Amoyel, UCL
Somatic Glycolysis Sustains Germ Cell Survival Through Lactate Shuttling in The Drosophila Testis
Nancy B De La Cruz, UT Southwestern Medical Center
Glucose 6-Phosphate Dehydrogenase Promotes Trophoblast Syncytialization
Kristina S Stapornwongkul, EMBL Barcelona
Metabolic Control Of Germ Layer Proportions Through Regulation Of Nodal And Wnt Signalling
Francesco Dalla Ricca, University of California, San Francisco
A Mitochondrial Redox Switch Licenses the Onset of Morphogenesis in Animals
Jose A Soto, UCLA
Metabolic Atlas of Early Human Cortical Development
Guido T Bommer, Universite Catholique de Louvain
Dolichol Synthesis: Novel Twists and Detours Involved in Human Disease
Ashish G Toshniwal, University of Utah
The Fate of Pyruvate: Metabolic regulation of Cell Growth
Athena Jessica S Ong, Peter MacCallum Cancer Centre
NRF2 Induces Cell Plasticity During Liver Tumour Initiation
Grigor Varuzhanyan, University of California Los Angeles
PGC-1α-Induced Mitochondrial Metabolism: Steering Lineage Fate in Small Cell Neuroendocrine Cancers
Coffee Available
3:30–4:00 PM
 Beverly Foyer
Nutritional Influences on Development
4:00–6:00 PM
 Beverly Room
Alex Gould, Francis Crick Institute
Cell-Type Specific Tagging and Tracing of Metabolites in Vivo
Vivian Gama, Vanderbilt University
Mitochondrial Fission Defects Drive Disruptive Neurogenesis in the Rare Disease EMPF1
Ömer H Yilmaz, Massachusetts Institute of Technology
Dietary Control of Stem Cells in Physiology and Disease
Nick Burton, Van Andel Institute
Short Talk: Microbial Metabolism of Polyamines and Pyruvate Regulate Animal Development
Veena Prahlad, Roswell Park Cancer Inst - Buffalo, NY
Short Talk: Neuronal IL-17 Controls Caenorhabditis Elegans Development In Response To Food Through the p53 ortholog CEP-1
Dinner
6:00–7:00 PM
 Newburyport
Friday, May 9, 2025
Breakfast
7:30–8:30 AM
 Beverly Foyer
Poster Setup
8:00–8:30 AM
 Ipswich
Poster Viewing
8:15–2:30 PM
 Ipswich
Metabolic Networks Defining Early Development
8:30–11:30 AM
 Beverly Room
Utpal Banerjee, UCLA
How Metabolism Drives Preimplantation Development
Tristan A Rodriguez, Imperial College London
Mitochondrial Control of Cell Competition During Development
Berna Sozen, Yale University
Glycolytic Gradients During Gastrulation
Eleni Kafkia, Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Short Talk: TCA Rewiring Underpins Implantation and Histone Acetylation Programming
Alba Villaronga-Luque, Max Planck Institute of Molecular Cell Biology and Genetics
Short Talk: Metabolic Control of Cell Fate Specification And Morphogenesis In A Mammalian Embryo Model
Tashbib Khan, BIDMC - Harvard Medical School
Short Talk: Glycogen Derived Glutamate Fuels TCA Cycle Function and Cellular Differentiation
Patrick Steinmetz, University of Bergen
Short Talk: Nutritional Regulation of Cellular Quiescence Depth In A Population Of Stem-Like Cells In A Sea Anemone
Coffee Break
9:30–9:50 AM
 Beverly Foyer
Lunch
11:30–12:30 PM
 Newburyport
Poster Session 2
12:30–2:30 PM
 Ipswich
Roundtable Discussion: Identifying Shared Priorities and Standards in a New Field
2:30–3:30 PM
 Beverly Room
Coffee Available
3:30–4:00 PM
 Beverly Foyer
Gene-Environment Interactions in Development
4:00–5:45 PM
 Beverly Room
Sally L. Dunwoodie, Victor Chang Cardiac Research Institute
Amino Acid Metabolism and Cardiac Development
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
Fixed Metabolic Defects and their Developmental Consequences
A.J. Marian Walhout, University of Massachusetts Medical School
Nutritional Regulatory Networks
Nuno Valente-Leal, Gulbenkian Institute for Molecular Medicine
Short Talk: The Sweet Path to Fertility: Transforming Sugars Into Viable Oocytes
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
5:45–6:00 PM
 Beverly Foyer
Transportation to Town for Dinner Options
6:30–10:00 PM
On Own for Dinner
6:30–10:00 PM
Saturday, May 10, 2025
Departure
8:00–9:00 AM

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