Microproteins: from Discovery to Applications

Feb 06–08, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

  In Person
  On Demand

Feb 06–08, 2025 | Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States
Scientific Organizers: Thomas F. Martínez, Lena Ho and Anne-Ruxandra Carvunis

Available Formats:   = In Person     = On Demand
Thursday, February 6, 2025
Registration
4:00–8:00 PM
 Wylie Inn Lobby/Cafe
Welcome Mixer
6:00–8:00 PM
 Wylie Inn Lobby/Cafe
Friday, February 7, 2025
Breakfast
7:30–8:30 AM
 Beverly Foyer
Poster Setup
8:00–8:30 AM
 Ipswich
Poster Viewing
8:00–5:00 PM
 Ipswich
Welcome and Keynote Address
8:30–9:30 AM
 Beverly Room
Jonathan W. Yewdell, NIAID, National Institutes of Health
Noncanonical Translation as a Source of Novel Antigens
Microprotein Annotation Across Species
9:30–12:00 PM
 Beverly Room
Anne-Ruxandra Carvunis, University of Pittsburgh
Systems Approaches to Unravel Microprotein Biology in S. cerevisiae
Kousuke Hanada, Kyushu Institute of Technology
Identification and Characterization of Microproteins in Arabidopsis
Julie Aspden, University of Leeds
Discovery of Non-Canonical Peptides during Neuronal Differentiation
Ariel Alejandro Bazzini, Stowers Institute for Medical Research
Short Talk: Translation of Small Downstream Orfs (Dorf) Enhances Translation of Canonical Main Open Reading Frames
Gisela Storz, NICHD, NIH
Short Talk: Regulating Membrane Protein Stability with Small Proteins
Coffee Break
10:00–10:20 AM
 Beverly Foyer
Lunch
12:00–1:00 PM
 Newburyport
Poster Session 1
12:30–3:00 PM
 Ipswich
Coffee Available
3:00–3:30 PM
 Beverly Foyer
Disease-Regulating Microproteins
3:30–5:30 PM
 Beverly Room
Thomas F. Martínez, University of California, Irvine
Uncovering Novel Microprotein Regulators of Squamous Cell Carcinoma Growth
Jennifer Snead, Velia
Identifying drug targets from the microproteome
Catherine A. Makarewich, Cincinnati Children's Hospital Medical Center
Microproteins Implicated in Heart Failure
Jin Chen, Altos Labs
Functional Genomics Strategies Reveal Microproteins Involved in Disease
On Own for Dinner
5:30–9:30 PM
Transportation to Dinner Options
5:45–9:30 PM
Saturday, February 8, 2025
Breakfast
7:30–8:30 AM
 Beverly Foyer
Poster Setup
8:00–8:30 AM
 Ipswich
Poster Viewing
8:00–5:00 PM
 Ipswich
Microprotein Interactions and Functions
8:30–11:30 AM
 Beverly Room
Lena Ho, Duke-NUS Medical School
Microprotein Interactions with Mitochondrial Protein Complexes
Christine Brun, TAGC Inserm-Univ. Mediterranee
Computational Predictions of Microprotein Interactions
Sarah Slavoff, Yale University
Microproteins and Chromatin Modifying-Proteins
Ryan L. Boudreau †, University of Iowa
Short Talk: A Misannotated LncRNA that is Dysregulated in Alzheimer’s Disease Encodes a Microprotein that Influences Amyloid Beta Processing and Learning and Memory in Mice
Yiwen Chen, University of Texas MD Anderson Cancer Center
Short Talk: Large-Scale Approaches to Unravel the Functions of the “Dark” Proteome in Cancer Signaling Pathways
Jasmyn Hoeger, University of Iowa
Short Talk: Discovery and Initial Characterization of a Diverse Family of Microproteins Derived from Alternative Open Reading Frames in SCN(NaV) Genes
Coffee Break
9:30–9:50 AM
 Beverly Foyer
Lunch
11:30–12:30 PM
 Newburyport
Poster Session 2
12:00–2:30 PM
 Ipswich
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
 Beverly Room
Nasim Akbari, University of Saskatchewan
The Human Microproteins Encoded by Long Non-Coding Rnas LINC00888 and LINC00887 are Potent Restriction Factors for Enterovirus D68
Igor Fesenko, NIH
Evolution of Bacterial Microproteome
Puri Fortes †, Foundation for Applied Medical Research
Microproteins Translated from Long Non-Coding Rnas Expressed in Liver and Breast Cancer are Required for Cell Growth and Produce Tumor-Specific Antigens of Interest for Anticancer Vaccination
Vighnesh V Ghatpande, The University of Texas at Austin
Single-Embryo Ribosome Profiling Reveals Pervasive Non-Canonical Translation Oof Micropeptides During Early Mouse Embryonic Development
Beyza-Nur Güven, Goethe-University Frankfurt
The Inflammation-Induced Microprotein Mip-PSTPIP2 Modulates Intracellular Trafficking and Endothelial Cell Activation
Fabricio Loayza-Puch, German Cancer Research Center
Upstream Open Reading Frame Translation Generates Microproteins and Enhances Immunogenic Peptide Presentation in Mitotically Arrested Cancer Cells
Neelanjan Mukherjee †, University of Colorado School of Medicine
Proteogenomic Discovery of Neoepitopes in Human Beta Cells
Daniel Rebibo, Sanford Burnham Prebys
Characterizing the MYC-Regulated Microproteome in B-Cell Lymphoma
Coffee Available
4:30–5:00 PM
 Beverly Foyer
The Functional Potential of Natural and Synthetic Microproteins
5:00–6:45 PM
 Beverly Room
Gabriel Jacob Rocklin, Northwestern University
Stability and Dynamics of Miniproteins at Scale
Xuebing Wu, Columbia University
Noncoding Translation Mitigation
Aaron Wacholder, University of Pittsburgh School of Medicine
Evolutionary Multi-Omics Strategies for Microprotein Characterization
Alex S Holehouse, Washington University in St. Louis
Short Talk: Prediction of Microprotein Conformational Ensembles and Intermolecular Interactions from Sequence
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
 Beverly Room
Dinner
7:00–8:00 PM
 Tupper Manor Ballroom
Sunday, February 9, 2025
Departure
8:00–9:00 AM

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