Joint with: Somatic Mosaicism in Human Development, Aging, and Diseases
Aging: New Frontiers in Rejuvenation and Gerotherapeutics

Feb 17–20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Ashley Webb, Morgan Levine and Dario Riccardo Valenzano

  In Person
  On Demand

Feb 17–20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Ashley Webb, Morgan Levine and Dario Riccardo Valenzano

Available Formats:   = In Person     = On Demand
Monday, February 17, 2025
Registration
4:00–8:00 PM
 Colorado Ballroom Foyer
Welcome Mixer
6:00–8:00 PM
 Colorado Ballroom Foyer
Tuesday, February 18, 2025
Breakfast
7:00–8:00 AM
 Summit Gallery
Welcome and Keynote Address
8:00–9:00 AM
 Peaks 4 - 5
Anne Brunet, Stanford University
Epigenetics, Stem Cells, Longevity
Chromatin and Epigenetics in Aging
9:00–11:15 AM
 Peaks 4 - 5
Shelley L Berger, University of Pennsylvania
Mechanisms of Chromatin Regulation in Aging
Carlos Giovanni Silva Garcia, Brown University
Molecular Mechanisms Linking Epigenetic Changes to Longevity
Vera Gorbunova, University of Rochester
DNA Repair Mechanisms in Aging and Longevity
Philine Guckelberger †, Max-Planck Institute for Molecular Genetics
Short Talk: Cohesin-Mediated 3d Contacts Tune Enhancer-Promoter Regulation
Coffee Break
9:30–9:50 AM
 Colorado Ballroom Foyer
Meet the Editors
11:15–12:15 PM
 Peaks 4 - 5
Poster Setup
11:15–1:00 PM
 Breckenridge Ballroom
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
 Breckenridge Ballroom
Symposia Spotlight 1: New Horizons in Artificial Intelligence
2:30–4:30 PM
 Peaks 4 - 5
Lucas Paulo de Lima Camillo †, Shift Bioscience
CpGPT: A Foundation Model For Dna Methylation
Kejun Ying †, Harvard University
MethylGPT: A Foundation Model for the Dna Methylome
Coffee Available
4:30–5:00 PM
 Colorado Ballroom Foyer
Artificial Intelligence and Machine Learning Modeling of Cell States and Transitions
5:00–7:00 PM
 Peaks 4 - 5
Morgan Levine, Altos Labs
Machine Learning and Aging Clocks
Matt Buckley, Retro Biosciences
Machine Learning Applications in Single Cell 'Omics
Jacob Kimmel, NewLimit
In silico Design of Rejuvenating Interventions
Michael Wosczyna †, NYU Grossman School of Medicine
Short Talk: Machine Learning-Based Dimensional Reduction Of Multiparameter Cellular Morphometrics Defines Senescence Across Age
Rupa Sridharan †, University of Wisconsin-Madison
Short Talk: Untangling Cellular States Of Rejuvenation And Cell Identity In Induced Pluripotency
Social Hour with Lite Bites
7:00–8:00 PM
 Breckenridge Ballroom
Poster Session 1
7:30–10:00 PM
 Breckenridge Ballroom
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
 Summit Gallery
Metabolism and the Microbiome in Healthspan and Longevity
8:00–11:00 AM
 Peaks 4 - 5
Dario Riccardo Valenzano, Leibniz Institute on Aging
Host-Microbiome Interactions in Aging
Meng C. Wang, HHMI/Janelia Research Campus
Organelle and Metabolic Homeostasis
Thomas Mortimer †, IRB Barcelona
Talk Title to be Announced
Sean M. Gibbons, Institute for Systems Biology
Interactions Between the Gut Microbiome and Host Frailty
Peter James Mullen †, University of Southern California
Short Talk: A Metabolic Atlas of Mouse Aging
Michael Petrascheck †, Scripps Research
Short Talk: A Gero-Neuroprotector That Restores Mitochondrial Function To Extend Lifespan
Coffee Break
9:00–9:20 AM
 Colorado Ballroom Foyer
Poster Setup
11:00–1:00 PM
 Breckenridge Ballroom
On Own for Lunch
11:00–1:30 PM
Poster Viewing
1:00–10:00 PM
 Breckenridge Ballroom
Symposia Spotlight 2: Therapeutics for Healthy Aging
1:30–3:15 PM
 Peaks 4 - 5
Reza Dana †, Harvard Medical School
Effects of Advancing Age on Dysregulation of Ocular Immune Homeostasis
Nancy Morones †, Cedars-Sinai Medical Center
Age-Dependent Dysregulation of Hypothalamic Circuits Contributes to Thermoregulatory Decline and Water Homeostasis Deficits in Aged Mice
Hong Seok Shim †, The University of Texas MD Anderson Cancer Center
Maintenance of Somatic Tert Levels as An Antiaging Strategy
Pengze Yan †, Dana-Farber Cancer Institute
Midkine as a Key Driver of Both Aging and Mammary Tumorigenesis
Julio Aguado †, University of Colorado
Virus-Induced Senescence: A Driver of Post-Acute Neurotropic Infection Syndrome
Albert Higgins-Chen †, Yale University
Responsiveness of Dnam Aging Biomarkers Across 51 Longevity Interventional Studies In Humans
Ee Phie Tan †, Scripps Research Institute
Investigating Small Molecule Autophagy Activator Aa-20: From Lipophagy In Mammals To Longevity In C. Elegans
Career Roundtable (Joint)
3:30–4:30 PM
 Peaks 4 - 5
Coffee Available
4:30–5:00 PM
 Colorado Ballroom Foyer
Stem Cells and Regeneration of Aged Tissues
5:00–7:00 PM
 Peaks 4 - 5
Ashley Webb, Buck Institute on Aging
Epigenetic Mechanisms of Neural Stem Cell Aging
Darcie L. Moore, University of Wisconsin-Madison
Mechanisms Underlying Neural Stem Cell Quiescence
Leanne Jones, University of California, San Francisco
Metabolic and Signaling Mechanisms of Stem Cell Homeostasis
Fabrizio d'Adda di Fagagna †, IFOM ETS–The AIRC Institute of Molecular Oncology
Short Talk: Telomere Biology in Aging and Disease
Social Hour with Lite Bites
7:00–8:00 PM
 Breckenridge Ballroom
Poster Session 2
7:30–10:00 PM
 Breckenridge Ballroom
Thursday, February 20, 2025
Breakfast
7:00–8:00 AM
 Summit Gallery
Epigenetic Reprogramming and Rejuvenation
8:00–11:00 AM
 Peaks 4 - 5
Vittorio Sebastiano, Stanford University
Nuclear Reprogramming to Ameliorate Aging
Berenice A Benayoun, University of Southern California
Epigenetic Mechanisms of Immune Aging and Rejuvenation
Alejandro Ocampo, University of Lausanne
Improving Healthy Aging Through Cellular Reprogramming
Irene de Lazaro †, New York University
Short Talk: In Vivo Partial Reprogramming of Cardiomyocytes to a Molecularly Rejuvenated State Ameliorates Cardiac Failure
Todd Dowrey †, Boston University
Short Talk: Uncovering the Mechanisms of Exceptional Longevity Through Ipsc-Based Modeling of Resiliency
Yinqing Li †, Tsinghua University
Short Talk: Uncovering the Mechanisms of Exceptional Longevity Through Ipsc-Based Modeling of Resiliency
Manuel Collado †, Health Research Institute of Santiago de Compostela Foundation - FIDIS
Short Talk: Senomorphic Effect of Partial Reprogramming
Coffee Break
9:00–9:20 AM
 Colorado Ballroom Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 3: The Regenerative Potential of Stem Cells in Aging
2:30–4:30 PM
 Peaks 4 - 5
Luka Culig †, National Institute on Aging
One Year of Early-Onset Cyclic Partial Reprogramming in Non-Progeric Nolife Mice Shows Heterogeneous Effects Across Multiple Health Indices
Daniel J Simpson †, Mayo Clinic
PRC2 Ageindex: A Universal Biomarker Of Aging And Rejuvenation
Walter Sandt †, CECAD
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
Angelina Holcom †, Buck Institute for Research on Aging
Exploring Metabolic Dynamics in Quiescent Versus Activated Neural Stem Cells
Jingxun Chen, Stanford University - Stanford, CA
Vertebrate Organ Aging Impacted by Sexual Interaction
Coffee Available
4:30–5:00 PM
 Colorado Ballroom Foyer
Gerotherapeutics
5:00–6:45 PM
 Peaks 4 - 5
Matt Kaeberlein, Optispan
Targeting Conserved Mechanisms of Aging
James Peyer, Cambrian Bio
Enhancing Healthspan Through Targeted Therapeutics
Cynthia Kenyon, Calico Life Sciences
Advances in Longevity Research
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Targeting Chronic Inflammation in the Brain
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
 Peaks 4 - 5
Social Hour with Lite Bites
7:00–8:00 PM
 Breckenridge Ballroom
Entertainment
8:00–9:00 PM
 Peaks 4 - 5
Cash Bar
8:00–9:00 PM
 Peaks 4 - 5
Friday, February 21, 2025
Departure
12:00–11:59 PM

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