Joint with: Somatic Mosaicism in Human Development, Aging, and Diseases
Aging: New Frontiers in Rejuvenation and Gerotherapeutics
Feb 17–20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:
Ashley Webb, Morgan Levine and Dario Riccardo Valenzano
In Person
On Demand
Feb 17–20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:
Ashley Webb, Morgan Levine and Dario Riccardo Valenzano
Available Formats:
Supported by:
In Person
On Demand
Available Formats: = In Person = On Demand
Monday, February 17, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
3rd Floor Foyer
Welcome Mixer
6:00–8:00 PM
3rd Floor Foyer
Tuesday, February 18, 2025
Breakfast
7:00–8:00 AM
Summit Gallery
Welcome and Keynote Address
8:00–9:00 AM
Colorado Ballroom
* Dario Riccardo Valenzano, Leibniz Institute on Aging
Session Chair
Session Chair
Anne Brunet, Stanford University
Quantifying and Targeting Aging
Quantifying and Targeting Aging
Chromatin and Epigenetics in Aging
9:00–11:15 AM
Colorado Ballroom
* Dario Riccardo Valenzano, Leibniz Institute on Aging
Session Chair
Session Chair
Shelley L Berger, University of Pennsylvania
Mechanisms of Chromatin Regulation in Aging
Mechanisms of Chromatin Regulation in Aging
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Targeting Chronic Inflammation in the Brain
Targeting Chronic Inflammation in the Brain
Vera Gorbunova, University of Rochester
DNA Repair Mechanisms in Aging and Longevity
DNA Repair Mechanisms in Aging and Longevity
Philine Guckelberger, Max-Planck Institute for Molecular Genetics
Short Talk: Cohesin-Mediated 3d Contacts Tune Enhancer-Promoter Regulation
Short Talk: Cohesin-Mediated 3d Contacts Tune Enhancer-Promoter Regulation
Coffee Break
9:30–9:50 AM
3rd Floor Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
Colorado Ballroom
Meet the Editors
11:15–12:15 PM
Colorado Ballroom
Ines Alvarez-Garcia, PLOS Biology
*Session Chair, Senior Editor
*Session Chair, Senior Editor
Michael Basson, Springer Nature
Senior Editor
Senior Editor
Ahmet M. Denli, Cold Spring Harbor Laboratory
Associate Editor
Associate Editor
George Inglis, Nature Portfolio
Senior Editor
Senior Editor
Poster Setup
11:15–1:00 PM
Peaks 1 - 3
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Peaks 1 - 3
Symposia Spotlight 1: Therapeutics for Healthy Aging
2:30–4:30 PM
Colorado Ballroom
* Jacob Kimmel, NewLimit
Session Chair
Session Chair
* Philine Guckelberger, Max-Planck Institute for Molecular Genetics
Session Chair
Session Chair
Reza Dana, Harvard Medical School
Effects of Advancing Age on Dysregulation of Ocular Immune Homeostasis
Effects of Advancing Age on Dysregulation of Ocular Immune Homeostasis
Nancy Morones, Cedars-Sinai Medical Center
Age-Dependent Dysregulation of Hypothalamic Circuits Contributes to Thermoregulatory Decline and Water Homeostasis Deficits in Aged Mice
Age-Dependent Dysregulation of Hypothalamic Circuits Contributes to Thermoregulatory Decline and Water Homeostasis Deficits in Aged Mice
Hong Seok Shim, The University of Texas MD Anderson Cancer Center
Maintenance of Somatic Tert Levels as An Antiaging Strategy
Maintenance of Somatic Tert Levels as An Antiaging Strategy
Pengze Yan, Dana-Farber Cancer Institute
Midkine as a Key Driver of Both Aging and Mammary Tumorigenesis
Midkine as a Key Driver of Both Aging and Mammary Tumorigenesis
Julio Aguado, University of Colorado
Virus-Induced Senescence: A Driver of Post-Acute Neurotropic Infection Syndrome
Virus-Induced Senescence: A Driver of Post-Acute Neurotropic Infection Syndrome
Albert T Higgins-Chen, Yale University
Responsiveness of Dnam Aging Biomarkers Across 51 Longevity Interventional Studies In Humans
Responsiveness of Dnam Aging Biomarkers Across 51 Longevity Interventional Studies In Humans
Ee Phie Tan, Scripps Research Institute
Investigating Small Molecule Autophagy Activator Aa-20: From Lipophagy In Mammals To Longevity In C. Elegans
Investigating Small Molecule Autophagy Activator Aa-20: From Lipophagy In Mammals To Longevity In C. Elegans
Coffee Available
4:30–5:00 PM
3rd Floor Foyer
Artificial Intelligence and Machine Learning Modeling of Cell States and Transitions
5:00–7:00 PM
Colorado Ballroom
* Morgan Levine, Altos Labs
Engineering Multiscale Health
Engineering Multiscale Health
Jacob Kimmel, NewLimit
In silico Design of Rejuvenating Interventions
In silico Design of Rejuvenating Interventions
Kejun Ying, Harvard University
Short Talk: MethylGPT: A Foundation Model for the Dna Methylome
Short Talk: MethylGPT: A Foundation Model for the Dna Methylome
Michael Wosczyna, NYU Grossman School of Medicine
Short Talk: Machine Learning-Based Dimensional Reduction Of Multiparameter Cellular Morphometrics Defines Senescence Across Age
Short Talk: Machine Learning-Based Dimensional Reduction Of Multiparameter Cellular Morphometrics Defines Senescence Across Age
Rupa Sridharan, University of Wisconsin-Madison
Short Talk: Untangling Cellular States Of Rejuvenation And Cell Identity In Induced Pluripotency
Short Talk: Untangling Cellular States Of Rejuvenation And Cell Identity In Induced Pluripotency
Lucas Paulo de Lima Camillo, Shift Bioscience
Short Talk: CpGPT: A Foundation Model For Dna Methylation
Short Talk: CpGPT: A Foundation Model For Dna Methylation
Social Hour with Lite Bites
7:00–8:00 PM
Peaks 1 - 3
Poster Session 1
7:30–10:00 PM
Peaks 1 - 3
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
Summit Gallery
Metabolism and the Microbiome in Healthspan and Longevity
8:00–11:00 AM
Colorado Ballroom
Dario Riccardo Valenzano, Leibniz Institute on Aging
Host-Microbiome Interactions in Aging
Host-Microbiome Interactions in Aging
* Meng C. Wang, HHMI/Janelia Research Campus
Organelle and Metabolic Homeostasis
Organelle and Metabolic Homeostasis
Thomas Mortimer, IRB Barcelona
Circadian Clock Communication During Homeostasis and Ageing
Circadian Clock Communication During Homeostasis and Ageing
Sean M. Gibbons, Institute for Systems Biology
Interactions Between the Gut Microbiome and Host Frailty
Interactions Between the Gut Microbiome and Host Frailty
Peter James Mullen, University of Southern California
Short Talk: A Metabolic Atlas of Mouse Aging
Short Talk: A Metabolic Atlas of Mouse Aging
Michael Petrascheck, Scripps Research
Short Talk: A Gero-Neuroprotector That Restores Mitochondrial Function To Extend Lifespan
Short Talk: A Gero-Neuroprotector That Restores Mitochondrial Function To Extend Lifespan
Coffee Break
9:00–9:20 AM
3rd Floor Foyer
Poster Setup
11:00–1:00 PM
Peaks 1 - 3
On Own for Lunch
11:00–1:30 PM
Poster Viewing
1:00–10:00 PM
Peaks 1 - 3
Career Roundtable (Joint)
3:30–4:30 PM
Colorado Ballroom
Hao Zhu, University of Texas Southwestern Medical Center
Associate Professor & Attending Physician
Associate Professor & Attending Physician
Cindy Guidi, AstraZeneca
Principal Scientist
Principal Scientist
Mitchell Lee, Ora Biomedical, Inc.
Michael J Corley, Weill Cornell Medicine
Associate Professor
Associate Professor
Coffee Available
4:30–5:00 PM
3rd Floor Foyer
Stem Cells and Regeneration of Aged Tissues
5:00–7:00 PM
Colorado Ballroom
* Ashley Webb, Buck Institute on Aging
Session Chair
Session Chair
Michael A. Bonaguidi, University of Southern California
Harnessing Cell State Transitions for Cognitive Rejuvenation
Harnessing Cell State Transitions for Cognitive Rejuvenation
Darcie L. Moore, University of Wisconsin-Madison
Mechanisms Underlying Neural Stem Cell Quiescence
Mechanisms Underlying Neural Stem Cell Quiescence
Leanne Jones, University of California, San Francisco
Metabolic and Signaling Mechanisms of Stem Cell Homeostasis
Metabolic and Signaling Mechanisms of Stem Cell Homeostasis
Fabrizio d'Adda di Fagagna, IFOM ETS–The AIRC Institute of Molecular Oncology
Short Talk: Telomere Biology in Aging and Disease
Short Talk: Telomere Biology in Aging and Disease
Social Hour with Lite Bites
7:00–8:00 PM
Peaks 1 - 3
Poster Session 2
7:30–10:00 PM
Peaks 1 - 3
Thursday, February 20, 2025
Breakfast
7:00–8:00 AM
Summit Gallery
Epigenetic Reprogramming and Rejuvenation
8:00–11:00 AM
Colorado Ballroom
* Vittorio Sebastiano, Stanford University
Nuclear Reprogramming to Ameliorate Aging
Nuclear Reprogramming to Ameliorate Aging
Berenice A Benayoun, University of Southern California
Epigenetic Mechanisms of Immune Aging and Rejuvenation
Epigenetic Mechanisms of Immune Aging and Rejuvenation
Alejandro Ocampo, University of Lausanne
Improving Healthy Aging Through Cellular Reprogramming
Improving Healthy Aging Through Cellular Reprogramming
Peng Liu, Retro Biosciences
In vivo Functional Rejuvenation by a Partial Reprogramming-based Approach
In vivo Functional Rejuvenation by a Partial Reprogramming-based Approach
Todd Dowrey, Boston University
Short Talk: Uncovering the Mechanisms of Exceptional Longevity Through Ipsc-Based Modeling of Resiliency
Short Talk: Uncovering the Mechanisms of Exceptional Longevity Through Ipsc-Based Modeling of Resiliency
Yinqing Li, Tsinghua University
Short Talk: ACC-seq Reveals Chromatin Condensate-Mediated Gene Regulation and its Role in Functional Decline
Short Talk: ACC-seq Reveals Chromatin Condensate-Mediated Gene Regulation and its Role in Functional Decline
Coffee Break
9:00–9:20 AM
3rd Floor Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Rejuvenation, Stem Cells, and Reprogramming
3:00–4:30 PM
Colorado Ballroom
* Kelsey Babcock, Brown University
Session Chair
Session Chair
Daniel J Simpson, Mayo Clinic
PRC2 Ageindex: A Universal Biomarker Of Aging And Rejuvenation
PRC2 Ageindex: A Universal Biomarker Of Aging And Rejuvenation
Walter Sandt, CECAD
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
Angelina Holcom, Buck Institute for Research on Aging
Exploring Metabolic Dynamics in Quiescent Versus Activated Neural Stem Cells
Exploring Metabolic Dynamics in Quiescent Versus Activated Neural Stem Cells
Jingxun Chen, Stanford University - Stanford, CA
Vertebrate Organ Aging Impacted by Sexual Interaction
Vertebrate Organ Aging Impacted by Sexual Interaction
Irene de Lazaro, New York University
In Vivo Partial Reprogramming of Cardiomyocytes to a Molecularly Rejuvenated State Ameliorates Cardiac Failure
In Vivo Partial Reprogramming of Cardiomyocytes to a Molecularly Rejuvenated State Ameliorates Cardiac Failure
Manuel Collado, Health Research Institute of Santiago de Compostela Foundation - FIDIS
Senomorphic Effect of Partial Reprogramming
Senomorphic Effect of Partial Reprogramming
Coffee Available
4:30–5:00 PM
3rd Floor Foyer
Gerotherapeutics
5:00–7:00 PM
Colorado Ballroom
* Carlos Giovanni Silva Garcia, Brown University
Cross-Generational Mechanisms of Longevity
Cross-Generational Mechanisms of Longevity
Mitchell Lee, Ora Biomedical, Inc.
Targeting Conserved Mechanisms of Aging
Targeting Conserved Mechanisms of Aging
James Peyer, Cambrian Bio
Enhancing Healthspan Through Targeted Therapeutics
Enhancing Healthspan Through Targeted Therapeutics
Ashley Webb, Buck Institute on Aging
Transcriptional Mechanisms of Brain Aging
Transcriptional Mechanisms of Brain Aging
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–7:15 PM
Colorado Ballroom
Social Hour with Lite Bites
7:15–8:15 PM
Peaks 1 - 3
Entertainment
8:00–9:00 PM
Colorado Ballroom
Cash Bar
8:00–9:00 PM
Peaks 1 - 3
Friday, February 21, 2025
Departure
12:00–11:59 PM
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