Joint with: Aging: New Frontiers in Rejuvenation and Gerotherapeutics
Somatic Mosaicism in Human Development, Aging, and Diseases

February 17-20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Jeong Ho Lee, E. Alice Lee and Peter Campbell

  In Person
  On Demand

February 17-20, 2025 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Jeong Ho Lee, E. Alice Lee and Peter Campbell

Available Formats:   = In Person     = On Demand
Monday, February 17, 2025
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, February 18, 2025
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Christopher A. Walsh, Children's Hospital Boston
Somatic Mosaicism in Human Brain Development and Aging
Developmental and Aging Process
9:00–11:15 AM
Inigo Martincorena, Wellcome Trust Sanger Institute
Somatic Mosaicism and Evolution in Healthy Human Tissues
Young Ju, Korea Advanced Institute of Science and Technology
Genomic and Epigenetic Mosaicism in Human Early Embryogenesis
Jan Vijg, Albert Einstein College of Medicine
Somatic Mosaicism as Aging Process in Human Tissues
Ana Cvejic, University of Cambridge
Mosaicism in the Development and Aging of Hematopoietic Organs
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
On Own for Lunch
11:15–5:00 PM
Poster Setup
11:15–1:00 PM
Poster Viewing
1:00–10:00 PM
Workshop 1: SMaHT Network Training Workshop
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Mechanism and Modeling of Somatic Mosaicism
5:00–7:00 PM
E. Alice Lee, Boston Children's Hospital & Harvard Medical School
Retrotransposon as a Non-Canonical Mechanism Driving Somatic Mosaicism
Kristin Baldwin, Columbia University
Modeling Somatic Mosaicism in iPSCs
Helen Bateup, University of California, Berkeley
Modeling Somatic Mosaicism in Brain Organoids
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
Technology and Tool Development
8:00–11:00 AM
Gilad Evrony, NYU Grossman School of Medicine
Sequencing the Single-Strand DNA Precursors of Somatic Mutations
Sangwoo Kim, Yonsei University
Benchmarking Tools to Detect Low-Level somatic Mosaicism
Peter J. Park, Harvard Medical School
A Pan-Tissue Survey of Mosaic Chromosomal Alterations
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Poster Setup
11:00–1:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable (Joint)
3:30–4:30 PM
Coffee Available
4:30–5:00 PM
Cancer Evolution
5:00–7:00 PM
Peter Campbell, Wellcome Trust Sanger Institute
Somatic Mosaicism in Premalignant State and Cancer Evolution
Nuria Lopez-Bigas, IRB Barcelona
Clonal Selection in Normal Tissues and its Relation to Cancer Risk
Kelly Bolton, Washington University
Clonal Hematopoiesis Impacting Cancer Evolution and Therapy
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, February 20, 2025
Breakfast
7:00–8:00 AM
Non-Malignant Diseases
8:00–11:00 AM
Stéphanie Baulac, Paris Brain Institute and Institut du Cerveau (ICM)
Somatic Mosaicism in Epileptogenesis
Frederic Geissmann, Memorial Sloan Kettering Cancer Center
Oncogenic Somatic Mosaicism in Neurodegenerative Disorders
Hao Zhu, University of Texas Southwestern Medical Center
Somatic Mosaicism and Clonal Selection in Metabolic Liver Disease
Satu Mustjoki, University of Helsinki
Somatic Mosaicism in Immune Cells and Autoimmune Disease
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Workshop 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Somatic Mosaicism in the Clinic
5:00–6:45 PM
Jeong Ho Lee, Korea Advanced Institute of Science and Technology
Genetic Diagnosis and Targeted Therapy in Intractable Focal Epilepsy with Somatic Mosaicism
Karyn Schmidt, Alnylam Pharmaceuticals
Mechanistic Advances in RNAi Therapeutics Platform, and Implications for Diseases with Somatic Mosaicism
Michael Collins, NIDCR, National Institutes of Health
Fibrous Dysplasia of Bone/McCune-Albright Syndrome (FD/MAS) with Mosaic Activation of Gsα Protein
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Social Hour with Lite Bites
7:00–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Friday, February 21, 2025
Departure
12:00–11:59 PM

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