Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities
January 1-4, 2026 | Location to be Determined
Scientific Organizers:
Karim-Jean Armache and Cigall Kadoch
In Person
On Demand
January 1-4, 2026 | Location to be Determined
Scientific Organizers:
Karim-Jean Armache and Cigall Kadoch
Available Formats:
In Person
On Demand
Supported by the Directors' Fund
Available Formats: = In Person = On Demand
Booking Function
Thursday, January 1, 2026
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Friday, January 2, 2026
Breakfast
7:00–8:00 AM
Welcome and Keynote Address
8:00–9:00 AM
Joanna Wysocka †, Stanford University
Epigenetic Regulators in Development and Disease
Epigenetic Regulators in Development and Disease
Chromatin Regulatory Mechanisms Governing Cell Fate in Health and Disease
9:00–11:15 AM
Robert J. Klose †, University of Oxford
Mechanisms of PRC1 in Transcription Repression
Mechanisms of PRC1 in Transcription Repression
Anja Groth †, University of Copenhagen
Maintaining Cell Fate through Replication
Maintaining Cell Fate through Replication
Karim-Jean Armache, New York University Grossman School of Medicine
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Structure and Function of Epigenetic Complexes: Basic and Disease Mechanisms
Scott A. Armstrong †, Dana-Farber Cancer Institute
Targeting the MLL-Menin Axis in Cancer
Targeting the MLL-Menin Axis in Cancer
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
On Own for Lunch
11:15–5:00 PM
Poster Setup
11:15–1:00 PM
Poster Viewing
1:00–10:00 PM
Coffee Available
4:30–5:00 PM
Therapeutic Opportunities Informed by Genetic Disruption of Chromatin Factors
5:00–7:00 PM
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Structure and Function of Chromatin Remodeling Complexes in Human Disease: From Basic Mechanisms to Therapeutic Opportunities
Nicolas H. Thomä †, Friedrich Miescher Institute for Biomedical Research
Structural Basis of Transcription Factors and Protein Degradation
Structural Basis of Transcription Factors and Protein Degradation
Isaac A. Klein †, Dewpoint Therapeutics
Targeting Transcription via Condensate Disruption
Targeting Transcription via Condensate Disruption
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Saturday, January 3, 2026
Breakfast
7:00–8:00 AM
Novel Target Identification and Chemical Approaches I
8:00–11:00 AM
Tom W. Muir †, Princeton University
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
New Chemical Approaches to Reveal and Understand Chromatin Mechanisms
Ho Man Chan †, AstraZeneca
Targeting Methyltransferases and Other Epigenetic Factors with Small Molecules
Targeting Methyltransferases and Other Epigenetic Factors with Small Molecules
Alessio Ciulli †, University of Dundee, School of Life Sciences
New Approaches Toward Chemical Degradation of Chromatin Machinery
New Approaches Toward Chemical Degradation of Chromatin Machinery
Steven Bellon †, Foghorn Therapeutics
Pharmacologic Disruption of Chromatin Regulatory Factors
Pharmacologic Disruption of Chromatin Regulatory Factors
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Mechanisms and Vulnerabilities Conferred by DNA Methylation
5:00–7:00 PM
Margaret A. Goodell †, Baylor College of Medicine
DNA Methylation in Cancer
DNA Methylation in Cancer
Chao Lu †, Columbia University
At the Crossroads of Histone Modifications and DNA Methylation Cancer
At the Crossroads of Histone Modifications and DNA Methylation Cancer
Jeffrey Settleman †, Pfizer
Epigenetics in the Era of Precision Medicine
Epigenetics in the Era of Precision Medicine
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
Posters
7:30–10:00 PM
Sunday, January 4, 2026
Breakfast
7:00–8:00 AM
Interplay between Chromatin Regulation and Transcription Dynamics in Human Disease
8:00–11:00 AM
Emily Bernstein †, Mount Sinai School of Medicine
Histone Variants and Their Functions in Cancer
Histone Variants and Their Functions in Cancer
Ali Shilatifard †, Northwestern University
Transcriptional Elongation and its Control of Oncogenic Mechanisms
Transcriptional Elongation and its Control of Oncogenic Mechanisms
Danny F. Reinberg †, University of Miami
Opportunities in Cancer
Opportunities in Cancer
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Coffee Available
4:30–5:00 PM
Novel Target Identification and Chemical Approaches II
5:00–6:45 PM
Effie Apostolou †, Weill Cornell Medical College
Regulatory Mechanisms of Transcription
Regulatory Mechanisms of Transcription
Nada Jabado †, McGill University Health Centre
Epigenetics of Pediatric Brain Cancers
Epigenetics of Pediatric Brain Cancers
Yadira M Soto-Feliciano †, Massachusetts Institute of Technology
Epigenetic Reprogramming and Cell Plasticity in Cancer
Epigenetic Reprogramming and Cell Plasticity in Cancer
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Social Hour with Lite Bites
7:00–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Monday, January 5, 2026
Departure
12:00–11:59 PM
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