Fibrosis: Inflammation, Drivers, and Therapeutic Resolution
December 8-11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Valerie Horsley, Michael T. Longaker and Thomas A Wynn
In Person
On Demand
December 8-11, 2024 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Valerie Horsley, Michael T. Longaker and Thomas A Wynn
Available Formats:
In Person
On Demand
Available Formats: = In Person = On Demand
Booking Function
Sunday, December 8, 2024
Registration
4:00–8:00 PM
Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
Macdonald Foyer
Monday, December 9, 2024
Breakfast
7:00–8:00 AM
MacDonald CDEF
Welcome and Keynote Address
8:00–9:00 AM
Macdonald AB
Neil C. Henderson, Institute of Regeneration and Repair, University of Edinburgh
State of the Art Technologies to Study Organ Fibrosis
State of the Art Technologies to Study Organ Fibrosis
Fibroblast Heterogeneity and Fibrosis
9:00–11:15 AM
Macdonald AB
Darlene Dixon, NIEHS, National Institutes of Health
Mechanisms of Uterine Fibroids
Mechanisms of Uterine Fibroids
Florian Rieder, Cleveland Clinic
Fibroblast-Driven Mechanisms in Intestinal Fibrosis
Fibroblast-Driven Mechanisms in Intestinal Fibrosis
Rafael Kramann, RWTH Aachen University
Dissecting Mechanisms of Kidney and Heart Fibrosis Using Single Cell and Spatial Genomics
Dissecting Mechanisms of Kidney and Heart Fibrosis Using Single Cell and Spatial Genomics
Tianhe Sun, Genentech, Inc.
Targeting TGF-beta 3 for Fibrotic Diseases
Targeting TGF-beta 3 for Fibrotic Diseases
Coffee Break
9:30–9:50 AM
Macdonald Foyer
On Own for Lunch
11:15–2:30 PM
Poster Setup
11:15–1:00 PM
MacDonald CDEF
Poster Viewing
1:00–10:00 PM
MacDonald CDEF
Symposia Spotlight 1: Beyond the Multiome: Integrating -Omics and AI in Fibrosis Models
2:30–4:30 PM
Macdonald AB
Rico Chandra Ardy, Sloan Kettering Institute
Comprehensive Transcription Factor Perturbations Recapitulate Fibroblast Transcriptional States
Comprehensive Transcription Factor Perturbations Recapitulate Fibroblast Transcriptional States
Ross Fitzsimmons †, University of Calgary
Multi-Omic Analysis of a Fibrosis-Prone Tendon in a Clinically Relevant Large Mammalian Model
Multi-Omic Analysis of a Fibrosis-Prone Tendon in a Clinically Relevant Large Mammalian Model
Jingyi Xia †, University of Michigan Ann Arbor
A 3D Image Atlas Chronicling Cellular and Structural Dynamics Following Lung Injury Identifies the Aberrant Expansion of Nonfunctional Endothelial Cells
A 3D Image Atlas Chronicling Cellular and Structural Dynamics Following Lung Injury Identifies the Aberrant Expansion of Nonfunctional Endothelial Cells
Ari Glasner †, Technion
Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment as Well as Injury Induced Lung Fibrosis Informs New Combination Therapy Strategies
Conserved Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment as Well as Injury Induced Lung Fibrosis Informs New Combination Therapy Strategies
Lesley A. Hill, University of British Columbia
Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and Their Impact on Liver Regeneration, Fibrosis and Resolution
Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and Their Impact on Liver Regeneration, Fibrosis and Resolution
Steve Ho, Pliant Therapeutics
Multi-Omic Approach Toward Identifying Pharmacodynamic Biomarkers in Fibrotic Human Liver Explants
Multi-Omic Approach Toward Identifying Pharmacodynamic Biomarkers in Fibrotic Human Liver Explants
Michal Polonsky, Caltech
Fibroblasts Act as Key Spatial Determinants Following Acute Kidney Injury
Fibroblasts Act as Key Spatial Determinants Following Acute Kidney Injury
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Mechanobiology in Regulation of Fibrosis
5:00–7:00 PM
Macdonald AB
Michael T. Longaker, Stanford School of Medicine
Mechanical Signaling in Skin Fibrosis and Repair
Mechanical Signaling in Skin Fibrosis and Repair
Daniel Tschumperlin, Mayo Clinic
Mechanical Regulation of Lung Fibrosis Development
Mechanical Regulation of Lung Fibrosis Development
Jennifer Elisseeff, Johns Hopkins University
T Cells and Senescence in Fibrosis
T Cells and Senescence in Fibrosis
Rachel Biggs, MUSC
Short Talk: Evidence for Persistent Fibrosis in Heart Failure with a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations
Short Talk: Evidence for Persistent Fibrosis in Heart Failure with a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations
Aya Nassereddine, Yale University
Short Talk: SUN2 Acts As A Mechanosensor For Fibrotic Response
Short Talk: SUN2 Acts As A Mechanosensor For Fibrotic Response
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CDEF
Poster Session #1
7:30–10:00 PM
MacDonald CDEF
Tuesday, December 10, 2024
Breakfast
7:00–8:00 AM
MacDonald CDEF
Inflammatory Drivers of Fibrosis
8:00–11:00 AM
Macdonald AB
Thomas A Wynn, Pfizer
Type 2 Immunity and Macrophages in the Pathogenesis of Fibrosis
Type 2 Immunity and Macrophages in the Pathogenesis of Fibrosis
Shruti Naik, Icahn School of Medicine at Mount Sinai
Inflammatory Memory in Skin Regeneration
Inflammatory Memory in Skin Regeneration
Jeff Biernaskie, University of Calgary
Fibroblast Dynamics during Regenerative versus Fibrotic Skin Repair
Fibroblast Dynamics during Regenerative versus Fibrotic Skin Repair
Vinicio de Jesus Perez, Stanford University
Targeting Hyaluronan in Pulmonary Hypertension Associated with Lung Fibrosis: Insights from the SATURN Study
Targeting Hyaluronan in Pulmonary Hypertension Associated with Lung Fibrosis: Insights from the SATURN Study
Anthony Chang, UCSF
Short Talk: Defining a Stromal Niche for Type 2-Like Regulatory T Cells
Short Talk: Defining a Stromal Niche for Type 2-Like Regulatory T Cells
Asma Farhat, Medical University of Vienna/CeMM
Short Talk: An Ageing Bone Marrow Exacerbates Lung Fibrosis Via a Dysregulated Regulatory T Cell Axis, Fueling Profibrotic Macrophage Persistence.
Short Talk: An Ageing Bone Marrow Exacerbates Lung Fibrosis Via a Dysregulated Regulatory T Cell Axis, Fueling Profibrotic Macrophage Persistence.
Coffee Break
9:00–9:20 AM
Macdonald Foyer
On Own for Lunch
11:00–3:00 PM
Poster Setup
11:00–1:00 PM
MacDonald CDEF
Poster Viewing
1:00–10:00 PM
MacDonald CDEF
Career Roundtable
3:00–4:30 PM
Macdonald AB
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Macrophage-Fibroblast Interactions
5:00–7:00 PM
Macdonald AB
Carla V. Rothlin, Yale University
Cell Death Mechanisms During Tissue Repair
Cell Death Mechanisms During Tissue Repair
Charlotte L. Scott, University of Ghent & VIB
Investigating Macrophage Functional Heterogeneity in the Fibrotic Liver
Investigating Macrophage Functional Heterogeneity in the Fibrotic Liver
Sabine Eming, University of Cologne
Metabolic Regulation of Macrophages in Skin Fibrosis
Metabolic Regulation of Macrophages in Skin Fibrosis
Shin-Huey Lin, National Tsing Hua University
Short Talk: Foxm1 Regulates Macrophage Polarization and Cytokine Secretion to Drive Renal Fibrosis After Acute Kidney Injury
Short Talk: Foxm1 Regulates Macrophage Polarization and Cytokine Secretion to Drive Renal Fibrosis After Acute Kidney Injury
Preethy Parthiban, University of Minnesota- Twin Cities
Short Talk: Macrophage-Derived CCL24 Promotes Fibrosis and Worsens Cardiac Dysfunction During Heart Failure
Short Talk: Macrophage-Derived CCL24 Promotes Fibrosis and Worsens Cardiac Dysfunction During Heart Failure
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CDEF
Poster Session #2
7:30–10:00 PM
MacDonald CDEF
Wednesday, December 11, 2024
Breakfast
7:00–8:00 AM
MacDonald CDEF
New Horizons: Resolving Fibrosis
8:00–11:00 AM
Macdonald AB
Valerie Horsley, Yale University
Cellular and Molecular Crosstalk During Fibrosis Resolution
Cellular and Molecular Crosstalk During Fibrosis Resolution
Rachel C. Chambers, University College London
Epithelial Progenitor Cells in Lung Fibrosis Resolution
Epithelial Progenitor Cells in Lung Fibrosis Resolution
Tatiana Kisseleva, University of California, San Diego
Portal Fibroblasts in Liver Fibrosis Resolution
Portal Fibroblasts in Liver Fibrosis Resolution
Resat Cinar, NIAAA, National Institutes of Health
Short Talk: Targeting Fibrometabolism Via Glutamate Mediated Metabotropic Glutamate Receptor 5 (Mglur5) Signaling in Pulmonary Fibroblasts to Reverse Pulmonary Fibrosis: Prospective of Repositioning Basimglurant, a Negative Allosteric Modulator of Mglur5
Short Talk: Targeting Fibrometabolism Via Glutamate Mediated Metabotropic Glutamate Receptor 5 (Mglur5) Signaling in Pulmonary Fibroblasts to Reverse Pulmonary Fibrosis: Prospective of Repositioning Basimglurant, a Negative Allosteric Modulator of Mglur5
Konrad Hoeft, RWTH Aachen University
Short Talk: ADAMTS12 Promotes Fibrosis by Restructuring Extracellular Matrix to Enable Activation and Migration of Injury-Responsive Fibroblasts
Short Talk: ADAMTS12 Promotes Fibrosis by Restructuring Extracellular Matrix to Enable Activation and Migration of Injury-Responsive Fibroblasts
Michelle Griffin, Stanford University
Short Talk: Piezo Inhibition Prevents and Rescues Scarring by Targeting the Adipocyte To Fibroblast Transition
Short Talk: Piezo Inhibition Prevents and Rescues Scarring by Targeting the Adipocyte To Fibroblast Transition
Hyun Young Kim, University of California San Diego
Short Talk: LARP6 Binding Modulates Mrna Translation in Human Liver Fibrosis
Short Talk: LARP6 Binding Modulates Mrna Translation in Human Liver Fibrosis
Coffee Break
9:00–9:20 AM
Macdonald Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Common Fibrosis Mechanisms: Lessons Across Tissues
2:30–4:30 PM
Macdonald AB
Lisa Ahne †, Martin-Luther-University Halle-Wittenberg
Silencing Neat1 Alleviates Fibrosis in an in Vivo Model Of Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Silencing Neat1 Alleviates Fibrosis in an in Vivo Model Of Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Kara Spiller, Drexel University
Biomaterials-Based Engineering of Macrophages for Regenerative Medicine
Biomaterials-Based Engineering of Macrophages for Regenerative Medicine
Sritejasvinithi Karimikonda, Medical College of Wisconsin
Exploring the Role of Fibroblast Reg3 Proteins In Response to Intestinal Inflammation
Exploring the Role of Fibroblast Reg3 Proteins In Response to Intestinal Inflammation
M. Carrie Miceli, University of California, Los Angeles
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
Sruthi Purushothaman †, University of British Columbia
The Nail Bed Orchestrates a Multicellular Response To Promote Mammalian Fingertip (Digit Tip) Regeneration Versus Fibrosis
The Nail Bed Orchestrates a Multicellular Response To Promote Mammalian Fingertip (Digit Tip) Regeneration Versus Fibrosis
Ryan M Friedman, University of Pennsylvania & Children's Hospital of Philadelphia
Inhibition of the MRTF-A/SRF Axis Alleviates Vocal Fold Scarring
Inhibition of the MRTF-A/SRF Axis Alleviates Vocal Fold Scarring
Anne-Katrine Z. Johansen, Cincinnati Children’s Hospital Medical Center
Down-Regulation of the Basic Helix-Loop-Helix Transcription Factor TCF21 is Necessary for the Development of Cardiac Fibrosis
Down-Regulation of the Basic Helix-Loop-Helix Transcription Factor TCF21 is Necessary for the Development of Cardiac Fibrosis
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Clinical Innovations in Fibrosis
5:00–6:45 PM
Macdonald AB
Martin L. Decaris, Pliant Therapeutics
Development of a Dual avb1/avb6 Oral Therapeutic for PSC and IPF
Development of a Dual avb1/avb6 Oral Therapeutic for PSC and IPF
Haig Aghajanian, Capstan Therapeutics
In vivo Generated CAR T Cells Targeting Pathogenic Fibroblasts for the Treatment of Cardiac Fibrosis
In vivo Generated CAR T Cells Targeting Pathogenic Fibroblasts for the Treatment of Cardiac Fibrosis
Speaker to be Announced
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Macdonald AB
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CDEF
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Fundraising
Thursday, December 12, 2024
Departure
12:00–11:59 PM
Merchandise Options
Registration Options
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