Biomolecular Condensates: Mechanisms and Therapeutic Opportunities

September 6-9, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mingjie Zhang and Jin Zhang

  In Person
  On Demand

September 6-9, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mingjie Zhang and Jin Zhang

Available Formats:   = In Person     = On Demand
Friday, September 6, 2024
Registration  
4:00–8:00 PM
 Colorado Ballroom Foyer
Welcome Mixer  
6:00–8:00 PM
 Colorado Ballroom Foyer
Saturday, September 7, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Welcome and Keynote Address  
8:00–9:00 AM
 Peaks 4 & 5
Michael K. Rosen, University of Texas Southwestern Medical Center
Phase Separation in Biological Systems
Mechanisms of Phase Separation  
9:00–11:15 AM
 Peaks 4 & 5
Tanja Mittag, St. Jude Children's Research Hospital
Physical basis of Condensate Aging Processes
Mingjie Zhang, Southern University of Science and Technology
Phase Separation in Synapses
Simon Alberti, Biotechnology Center of the TU Dresden
Phase Separation and Cell Stress Signaling
Anthony K. L. Leung, Johns Hopkins University/Leung Lab
Scope and Mechanism of Poly(ADP-ribose)-mediated Protein Condensation
Coffee Break  
9:30–9:50 AM
 Colorado Ballroom Foyer
On Own for Lunch  
11:15–5:00 PM
Poster Setup  
11:15–1:00 PM
 Peaks 1 - 3
Poster Viewing  
1:00–10:00 PM
 Foyer / Peaks 1 - 3
Workshop 1: Hot off the Press: Talks Selected from Abstracts  
2:30–4:30 PM
 Peaks 4 & 5
Saki Takayanagi, Johns Hopkins University
Development of a Molecular Tool iDoG to Explore the Physiological Roles of Biomolecular Condensates
Huabin Zhou, UTSW
Structures of Biomolecular Condensates
Daniel M Shapiro, Duke University
Synthetic Biomolecular Condensates Enhance Translation from a Target mRNA in Living Cells
Melanie Allram, University of Veterinary Medicine Vienna
The Role of lncRNAs in Biomolecular Condensation of Leukemia Fusion Oncoproteins
Kevin Rhine, UC San Diego
Neuronal Aging Leads to Chronic Activation of the Stress Response
Xiao Yan †, MPI-CBG
Biomolecular Condensates as Crucibles of Protein Aggregation
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Biological Condensates in Genomic Organization and Transcriptional Regulation  
5:00–7:00 PM
 Peaks 4 & 5
Dirk Görlich, Max Planck Institute for Multidisciplinary Sciences
Phase Separation in Nuclear Pore Formation and Function
Kirstin Meyer, UCSF
YAP Signal Integration Through Transcriptional Condensates
Pilong Li, Tsinghua University
Miscibility and Immiscibility of Condensates Control Chromatin Organization and Transcription
Jonathan Henninger, Carnegie Mellon University
RNA in the Regulation of Transcriptional Condensates
Marina Feric, Pennsylvania State University
Structure-Function Relationships in Mitochondrial Transcriptional Condensates
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1 - 3
Poster Viewing  
7:30–10:00 PM
 Peaks 1 - 3
Sunday, September 8, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Biological Condensates in Cell Signaling  
8:00–11:30 AM
 Peaks 4 & 5
Jin Zhang, University of California, San Diego
Phase Separation in Protein Kinase Signaling
Monica Sharma, Genentech
PD-1 Regulates the Formation of Protein Condensates in T-Cell Receptor Signaling
Sua Myong, Boston Children's Hospital
Size Regulation of FUS Condensates
Maria F Ullo, Massachusetts Institute of Technology
Tuning Epidermal Growth Factor Receptor (EGFR) Condensate Properties Through Adaptor Protein Valency and Competition
Yi Lin, Tsinghua University
Phase Separation and Circadian Rhythm
Lindsay Case, Massachusetts Institute of Technology
Phase Separation in Integrin Signaling
Coffee Break  
9:30–9:50 AM
 Colorado Ballroom Foyer
Lunch  
11:30–12:45 PM
 Peaks 1 - 3
Poster Viewing  
11:30–6:00 PM
 Peaks 1 - 3
Panel Discussion: Challenges and Opportunities of Phase Separation in Biology  
12:45–2:15 PM
 Peaks 4 & 5
Career Roundtable  
2:30–4:00 PM
 Peaks 4 & 5
Coffee Available  
4:00–4:30 PM
 Colorado Ballroom Foyer
Interface Between Membraneless and Membrane Organelles  
4:30–6:00 PM
 Peaks 4 & 5
Sarah L. Veatch, University of Michigan
Phase Separation in Cell Signaling
Joo-Yeon Yoo, Postech
Membrane-Associated SCOTIN Condensates in the Regulation of Organelle Stress Response and Dynamics
Hong Zhang, Chinese Academy of Sciences
Phase Separation in Autophagy
Neus Sanfeliu Cerdán, ICFO - The Institute of Photonic Sciences
Liquid-to-Solid Phase Transition of MEC-2 Condensates is Required for Mechanotransduction During Touch
Kandice Levental, University of Virginia
Phase Separation and Cell Signaling at Membrane Interface
On Own for Dinner  
6:00–7:00 PM
Monday, September 9, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Biomolecular Condensates: Disease Implications and Therapeutic Opportunities  
8:00–11:00 AM
 Peaks 4 & 5
Jidong Zhu, Etern Therapeutics
Harnessing Phase Separation for Drug Development
Shannon Moreno, Whitehead Institute
Condensate Proteolethargy is a Pathogenic Mechanism in Chronic Disease
Diego Vargas, Dewpoint Therapeutics
Small Molecules Regulating Biological Condensates
Eman Elshalia, University of Denver
G-Quadruplexes Modulate TDP-43 Aggregation In Vitro And In Vivo
Benjamin Wolozin, Aquinnah Pharmaceuticals and Boston University
Applying RNA Binding Proteins and Biological Condensates to Develop Therapeutic Pipelines for Amyotrophic Lateral Sclerosis and Alzheimer’s Disease
Dorothee Dormann, Johannes Gutenberg University Mainz
Phase Separation in Neurodegeneration
Coffee Break  
9:00–9:20 AM
 Colorado Ballroom Foyer
On Own for Lunch  
11:00–5:00 PM
Workshop 2: Young Investigator Forum  
2:30–4:30 PM
 Peaks 4 & 5
Huaiying Zhang, Carnegie Mellon University
TERRA-LSD1 Phase Separation Promotes R-Loop Formation for Telomere Maintenance in ALT Cancer Cells
Benjamin R. Sabari, University of Texas Southwestern Medical Center
Gain-of-Function RNA Polymerase II Partitioning is a Shared Feature of Diverse Oncogenic Fusions
Zheng Shi, Rutgers University
Alpha-Synuclein Regulates the Material Properties of Synapsin Condensates in Live Cells
Runwen Yao, UT Southwestern Medical Center
Size-Dependent Functional Transitions in Actin Signaling Protein Condensates
Barak Raveh, The Hebrew University of Jerusalem
Combining Molecular and Whole-Cell Models to Reveal Design Features Underlying Nucleocytoplasmic Transport
Salman Banani †, University of Chicago
Active RNA Synthesis Patterns Nuclear Condensates
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Methodologies for Phase Separation Research  
5:00–6:45 PM
 Peaks 4 & 5
Hao Wu, Harvard Medical School, Boston Children's Hospital
Inflammasomes: Condensates and Ordered Supramolecular Assemblies
Felipe Quiroz, Emory University and Georgia Institute of Technology
High-Fidelity Probing of Intracellular Phase Separation Dynamics
Joshua Riback, Baylor College of Medicine
Physical-Chemical Probing Reveals a Networked Nucleolar Structure Funneling Ribosome Biogenesis
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Peaks 4 & 5
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1 - 3
Entertainment  
8:00–9:00 PM
 Peaks 4 & 5
Cash Bar  
8:00–9:30 PM
 Peaks 1 - 3
Tuesday, September 10, 2024
Departure  
12:00–11:59 PM

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