Autophagosomes and Endolysosomes: From Fundamental Mechanisms to Disease Implications
Jun 25–28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Christina Towers, Rupert Beale and Leon O. Murphy
Jun 25–28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Christina Towers, Rupert Beale and Leon O. Murphy
Available Formats:
Supported by:
In Person
On Demand
Available Formats: = In Person = On Demand
Wednesday, June 25, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
Macdonald Foyer
Thursday, June 26, 2025
Breakfast
7:00–8:00 AM
MacDonald CD
Poster Setup
7:30–8:30 AM
MacDonald CD
Poster Viewing
7:45–7:00 PM
MacDonald CD
Welcome and Keynote Address
8:00–9:00 AM
Macdonald AB
Anne Simonsen, University of Oslo
Intracellular Membrane Trafficking Through Endolysosomes and Autophagy
Intracellular Membrane Trafficking Through Endolysosomes and Autophagy
Intersections of Endolysosomes and Autophagy
9:00–11:15 AM
Macdonald AB
Marja Jäättelä, Danish Cancer Institute
Targeting Lysosomal Ion and Lipid Homeostasis in Cancer Treatment
Targeting Lysosomal Ion and Lipid Homeostasis in Cancer Treatment
Chan Lee, Harvard Medical School
Short Talk: TRPML1 Activation Promotes CASM-Dependent Recruitment of DMXL1 to Lysosomes
Short Talk: TRPML1 Activation Promotes CASM-Dependent Recruitment of DMXL1 to Lysosomes
Malene Hansen, Buck Institute for Research on Aging
On Canonical and Non-Canonical Autophagy Gene Functions in Aging
On Canonical and Non-Canonical Autophagy Gene Functions in Aging
Rupert Beale, The Francis Crick Institute
Non-Canonical Autophagy Mechanisms
Non-Canonical Autophagy Mechanisms
Coffee Break
9:30–9:50 AM
Macdonald Foyer
Lunch
11:15–12:15 PM
MacDonald CD
Poster Session 1
12:00–2:30 PM
MacDonald CD
Symposia Spotlight 1: New Insights on Targeting Autophagy and Lysosomes
3:00–4:30 PM
Macdonald AB
Joseph D. Mancias, Dana-Farber Cancer Institute
Targeting Ferritinophagy in Cancer
Targeting Ferritinophagy in Cancer
Swetha Gowrishankar, University of Illinois at Chicago
Small Molecule Modulator of Neuronal Lysosome Positioning and Function Resolves Alzheimer’s Disease-Linked Pathologies in Cultured Human Neurons
Small Molecule Modulator of Neuronal Lysosome Positioning and Function Resolves Alzheimer’s Disease-Linked Pathologies in Cultured Human Neurons
Graham J Ray, MIT
Lysosomal RNA Profiling Reveals Targeting of Specific Types of RNAs for Degradation
Lysosomal RNA Profiling Reveals Targeting of Specific Types of RNAs for Degradation
Chantell S Evans, Duke University School of Medicine
Investigating the Temporal Dynamics of Mitophagy in Neurons
Investigating the Temporal Dynamics of Mitophagy in Neurons
Suganthi Chittaranjan, British Columbia Cancer Agency
Torin-1 Reduces the Survival Rate of Cells Escaping Combined Treatment with the ATG4B and ATG4A Inhibitor LV320 and Metformin in PDAC Models
Torin-1 Reduces the Survival Rate of Cells Escaping Combined Treatment with the ATG4B and ATG4A Inhibitor LV320 and Metformin in PDAC Models
Matthew Shurtleff †, Lycia Therapeutics
Catalytic Degradation of Circulating Targets with FcRn-Mediated cycling LYTACs
Catalytic Degradation of Circulating Targets with FcRn-Mediated cycling LYTACs
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Biophysics and Biochemistry of Autophagy
5:00–7:00 PM
Macdonald AB
Sascha Martens, University of Vienna
Mechanisms of Cargo Selection and Autophagosome Biogenesis
Mechanisms of Cargo Selection and Autophagosome Biogenesis
Jingyue Cassano, University of New Mexico
Short Talk: Lysosomes Collaborate with Biomolecular Condensates in Response to Damage
Short Talk: Lysosomes Collaborate with Biomolecular Condensates in Response to Damage
James H. Hurley, University of California, Berkeley
Mechanisms of Autophagy Initiation
Mechanisms of Autophagy Initiation
Priya Chouhan, CSIR-Institute of Microbial Technology
Short Talk: Arl8b Promotes LAMP1 Sorting to Endolysosomes by Inactivating Rab11-mediated Endocytic Recycling Pathway
Short Talk: Arl8b Promotes LAMP1 Sorting to Endolysosomes by Inactivating Rab11-mediated Endocytic Recycling Pathway
Tara D Fischer, National Institutes of Health
ATG8 and Ubiquitin Conjugation at Golgi-Related Membranes
ATG8 and Ubiquitin Conjugation at Golgi-Related Membranes
On Own for Dinner
7:00–8:00 PM
Friday, June 27, 2025
Breakfast
7:00–8:00 AM
MacDonald CD
Disease Relevance and Therapeutic Opportunities: Oncology and Metabolism
8:00–11:00 AM
Macdonald AB
Christina Towers, The Salk Institute for Biological Studies
Targeting Autophagy in Cancer
Targeting Autophagy in Cancer
Rushika M. Perera, University of California, San Francisco
Lysosomes in Cancer
Lysosomes in Cancer
Caleb Cheng †, University of Michigan
Short Talk: Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer
Short Talk: Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer
Noor Gammoh, The University of Edinburgh
Lysosome ATPases in Cancer
Lysosome ATPases in Cancer
Corey N Cunningham, University of Utah
Short Talk: The Orphan Transporter SLC16A6 is Required For Melanogenesis And Lysosomal Acidification
Short Talk: The Orphan Transporter SLC16A6 is Required For Melanogenesis And Lysosomal Acidification
Chiara Di Malta, Telethon Institute of Genetics and Medicine
TFEB in Metabolic Growth Disorders
TFEB in Metabolic Growth Disorders
Coffee Break
9:00–9:20 AM
Macdonald Foyer
Poster Setup
11:00–1:00 PM
MacDonald CD
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
MacDonald CD
Career Roundtable
3:00–4:30 PM
Macdonald AB
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Disease Relevance and Therapeutic Opportunities: Neurodegeneration
5:00–7:00 PM
Macdonald AB
Yvette C. Wong, Northwestern University
Inter-Organelle Lysosome Contact Sites in Health and Neurodegeneration
Inter-Organelle Lysosome Contact Sites in Health and Neurodegeneration
Mathieu Bourdenx †, University College London
Short Talk: Subcellular Proteomics Identify a Late-Endosome-Specific Signature Predicting Alzheimer's Disease Progression
Short Talk: Subcellular Proteomics Identify a Late-Endosome-Specific Signature Predicting Alzheimer's Disease Progression
Beat Nyfeler, Novartis Institutes for BioMedical Research
Identification of Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen
Identification of Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen
Claire E Richardson, UW Madison
Short Talk: TFEB/HLH-30-Mediated Expansion of Neuronal Lysosomal Capacity in Early Adulthood Maintains Dendrite Morphology and Neurotransmission During Caenorhabditis Elegans Aging
Short Talk: TFEB/HLH-30-Mediated Expansion of Neuronal Lysosomal Capacity in Early Adulthood Maintains Dendrite Morphology and Neurotransmission During Caenorhabditis Elegans Aging
Juan S. Bonifacino, National Institutes of Health
Endolysosomes and Neurodegeneration
Endolysosomes and Neurodegeneration
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CD
Poster Session 2
7:30–10:00 PM
MacDonald CD
Saturday, June 28, 2025
Breakfast
7:00–8:00 AM
MacDonald CD
Disease Relevance and Therapeutic Opportunities: Infection and Immunity
8:00–11:00 AM
Macdonald AB
Maximiliano Gutierrez, Francis Crick Institute
Xenophagy: Implications for Tuberculosis
Xenophagy: Implications for Tuberculosis
Feng Shao, National Institute of Biological Sciences
The Role of Autophagy Machinery in Anti-Bacterial Mechanisms
The Role of Autophagy Machinery in Anti-Bacterial Mechanisms
Damian Gatica, University of Ottawa
Short Talk: The ER-Phagy Receptor FAM134B/RETREG1 is Targeted by Salmonella Typhimurium to Promote Infection
Short Talk: The ER-Phagy Receptor FAM134B/RETREG1 is Targeted by Salmonella Typhimurium to Promote Infection
James Phelan, National Cancer Institute
The Role of the Autophagy Machinery in Immunity
The Role of the Autophagy Machinery in Immunity
Kathryn Jacobs, VIB center for cancer biology
Short Talk: Autophagy as a Key Regulator of High Endothelial Venule Identity and Function During Inflammation
Short Talk: Autophagy as a Key Regulator of High Endothelial Venule Identity and Function During Inflammation
Nicola Jones, University of Toronto
The Role of Autophagy in Helicobacter Pylori-Mediated Gastrointestinal Disease
The Role of Autophagy in Helicobacter Pylori-Mediated Gastrointestinal Disease
Coffee Break
9:00–9:20 AM
Macdonald Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Novel Techniques and Models to Interrogate Autophagosomes and Endolysosomes
2:30–4:30 PM
Macdonald AB
Oluwatobi A Adeosun †, University of Osnabrueck
Transbilayer Lipid Dynamics and Signaling in Lysosomal Repair
Transbilayer Lipid Dynamics and Signaling in Lysosomal Repair
Gabriel Baonza †, Centro de Biologia Molecular Severo Ochoa (CBMSO)
The V-ATPase/ATG16L1 Axis Drives Membrane Remodeling During Epithelial Morphogenesis
The V-ATPase/ATG16L1 Axis Drives Membrane Remodeling During Epithelial Morphogenesis
Monther Abu-Remaileh, Stanford University
Novel Techniqes to Study Endolysosomes
Novel Techniqes to Study Endolysosomes
Elizabeth Delorme-Axford, Oakland University
The Nonsense-Mediated mRNA Decay Factor Upf3 is a Negative Regulator of Autophagy in Yeast
The Nonsense-Mediated mRNA Decay Factor Upf3 is a Negative Regulator of Autophagy in Yeast
Michael A Mandell, University of New Mexico School of Medicine
TRIM46 Restrains CASM-Dependent Fragmentation of the Golgi Network
TRIM46 Restrains CASM-Dependent Fragmentation of the Golgi Network
Karyn King †, University of Ottawa
Discovery of Regulatory Pathways for CASM
Discovery of Regulatory Pathways for CASM
Tara Tigani, Peter MacCallum Cancer Centre
Employing a Metabolism Focused CRISPR Screen to Identify Novel Regulators of Lysosomal Biogenesis
Employing a Metabolism Focused CRISPR Screen to Identify Novel Regulators of Lysosomal Biogenesis
Coffee Available
4:30–5:00 PM
Macdonald Foyer
What Don't We Know About the Autophagy Pathway
5:00–6:45 PM
Macdonald AB
Leon O. Murphy, Casma Therapeutics
Targeting Autophagy: Where the Field Has Been and Where is it Going
Targeting Autophagy: Where the Field Has Been and Where is it Going
Timothy Sargeant †, SAHMRI
Short Talk: Physiological Human Autophagy Increases in the PBMC Pool In Human Ageing And Human Age-Related Disease
Short Talk: Physiological Human Autophagy Increases in the PBMC Pool In Human Ageing And Human Age-Related Disease
Ana Maria Cuervo, Albert Einstein College of Medicine
Chaperone Mediated Autophagy: Where the Field has Been and Where is it Going?
Chaperone Mediated Autophagy: Where the Field has Been and Where is it Going?
Noboru Mizushima, University of Tokyo
Autophagy Mechanisms: Where the Field has Been and Where is it Going?
Autophagy Mechanisms: Where the Field has Been and Where is it Going?
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Macdonald AB
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CD
Entertainment
8:00–9:00 PM
Macdonald AB
Cash Bar
8:00–9:00 PM
MacDonald CD
Sunday, June 29, 2025
Departure
12:00–11:59 PM
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