Autophagosomes and Endolysosomes: From Fundamental Mechanisms to Disease Implications

Jun 25–28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Christina Towers, Rupert Beale and Leon O. Murphy

  In Person
  On Demand

Jun 25–28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Christina Towers, Rupert Beale and Leon O. Murphy

Available Formats:   = In Person     = On Demand
Wednesday, June 25, 2025
Registration
4:00–8:00 PM
 Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
 Macdonald Foyer
Thursday, June 26, 2025
Breakfast
7:00–8:00 AM
 MacDonald CD
Poster Setup
7:30–8:30 AM
 MacDonald CD
Poster Viewing
7:45–7:00 PM
 MacDonald CD
Welcome and Keynote Address
8:00–9:00 AM
 Macdonald AB
Anne Simonsen, University of Oslo
Intracellular Membrane Trafficking Through Endolysosomes and Autophagy
Intersections of Endolysosomes and Autophagy
9:00–11:15 AM
 Macdonald AB
Marja Jäättelä, Danish Cancer Society Research Center
Targeting Lysosomal Ion and Lipid Homeostasis in Cancer Treatment
Claudine Kraft, University of Freiburg
Molecular Mechanisms in Autophagy
Rupert Beale, The Francis Crick Institute
Non-Canonical Autophagy Mechanisms
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
 Macdonald Foyer
Lunch
11:15–12:15 PM
 MacDonald CD
Poster Session 1
12:00–2:30 PM
 MacDonald CD
Symposia Spotlight 1: New Insights on Targeting Autophagy and Lysosomes
2:30–4:30 PM
 Macdonald AB
Joseph D. Mancias †, Dana-Farber Cancer Institute
Targeting Ferritinophagy in Cancer
Chantell S Evans, Duke University School of Medicine
Investigating the Temporal Dynamics of Mitophagy in Neurons
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Macdonald Foyer
Biophysics and Biochemistry of Autophagy
5:00–7:00 PM
 Macdonald AB
Sascha Martens, University of Vienna
Mechanisms of Cargo Selection and Autophagosome Biogenesis
James H. Hurley, University of California, Berkeley
Mechanisms of Autophagy Initiation
Phyllis I. Hanson, University of Michigan
ESCRT, Endolysosomes and Membrane Trafficking
Short Talk(s) Chosen from Abstracts
On Own for Dinner
7:00–8:00 PM
Friday, June 27, 2025
Breakfast
7:00–8:00 AM
 MacDonald CD
Disease Relevance and Therapeutic Opportunities: Oncology and Metabolism
8:00–11:00 AM
 Macdonald AB
Christina Towers, The Salk Institute for Biological Studies
Targeting Autophagy in Cancer
Rushika M. Perera, University of California, San Francisco
Lysosomes in Cancer
Noor Gammoh, The University of Edinburgh
Lysosome ATPases in Cancer
Chiara Di Malta, Telethon Institute of Genetics and Medicine
TFEB in Metabolic Growth Disorders
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Macdonald Foyer
Poster Setup
11:00–1:00 PM
 MacDonald CD
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
 MacDonald CD
Career Roundtable
3:00–4:30 PM
 Macdonald AB
Coffee Available
4:30–5:00 PM
 Macdonald Foyer
Disease Relevance and Therapeutic Opportunities: Neurodegeneration
5:00–7:00 PM
 Macdonald AB
Yvette C. Wong, Northwestern University
Inter-Organelle Lysosome Contact Sites in Health and Neurodegeneration
Beat Nyfeler, Novartis Institutes for BioMedical Research
Identification of Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen
Juan S. Bonifacino, National Institutes of Health
Endolysosomes and Neurodegeneration
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
 MacDonald CD
Poster Session 2
7:30–10:00 PM
 MacDonald CD
Saturday, June 28, 2025
Breakfast
7:00–8:00 AM
 MacDonald CD
Disease Relevance and Therapeutic Opportunities: Infection and Immunity
8:00–11:00 AM
 Macdonald AB
Maximiliano Gutierrez, Francis Crick Institute
Xenophagy: Implications for Tuberculosis
Feng Shao, National Institute of Biological Sciences
The Role of Autophagy Machinery in Anti-Bacterial Mechanisms
James Phelan, NCI, National Institutes of Health
The Role of the Autophagy Machinery in Immunity
Nicola Jones, University of Toronto
The Role of Autophagy in Helicobacter Pylori-Mediated Gastrointestinal Disease
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Macdonald Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Novel Techniques and Models to Interrogate Autophagosomes and Endolysosomes
2:30–4:30 PM
 Macdonald AB
Monther Abu-Remaileh, Stanford University
Novel Techniqes to Study Endolysosomes
Malene Hansen, Buck Institute for Research on Aging
On Canonical and Non-Canonical Autophagy Gene Functions in Aging
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Macdonald Foyer
What Don't We Know About the Autophagy Pathway
5:00–6:45 PM
 Macdonald AB
Leon O. Murphy, Casma Therapeutics
Targeting Autophagy: Where the Field Has Been and Where is it Going
Ana Maria Cuervo, Albert Einstein College of Medicine
Chaperone Mediated Autophagy: Where the Field has Been and Where is it Going?
Noboru Mizushima, University of Tokyo
Autophagy Mechanisms: Where the Field has Been and Where is it Going?
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
 Macdonald AB
Social Hour with Lite Bites
7:00–8:00 PM
 MacDonald CD
Entertainment
8:00–9:00 PM
 Macdonald AB
Cash Bar
8:00–9:00 PM
 MacDonald CD
Sunday, June 29, 2025
Departure
12:00–11:59 PM

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