DNA Replication Gaps, Cancer and Disease
Apr 27–30, 2025 | Daejeon Convention Center, Daejeon, South Korea
Scientific Organizers:
Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung
In Person
On Demand
Apr 27–30, 2025 | Daejeon Convention Center, Daejeon, South Korea
Scientific Organizers:
Sharon B. Cantor, Alberto Ciccia, Vincenzo Costanzo and Kyungjae Myung
Available Formats:
Supported by:
In Person
On Demand
Available Formats: = In Person = On Demand
Merchandise Options
Registration Options
Sunday, April 27, 2025
Fundraising
Booking Function
Registration
4:00–8:00 PM
2nd Floor Lobby/Terrace
Welcome Mixer
6:00–8:00 PM
2nd Floor Lobby/Terrace
Monday, April 28, 2025
Breakfast
7:30–8:30 AM
Individual Hotel
Poster Setup
8:00–8:30 AM
Room 202
Poster Viewing
8:00–5:00 PM
Room 202
Welcome and Keynote Address
8:30–9:30 AM
Room 201
Helle D. Ulrich, Institute of Molecular Biology
Mind the Gap: How Ubiquitylation Controls Postreplicative Gap Formation and Repair in Response to DNA Replication Stress
Mind the Gap: How Ubiquitylation Controls Postreplicative Gap Formation and Repair in Response to DNA Replication Stress
DNA Replication Gaps: Causes and Consequences
9:30–12:00 PM
Room 201
Vincenzo Costanzo, IFOM
Causes and Consequences of DNA Replication Gaps
Causes and Consequences of DNA Replication Gaps
Alessandro Vindigni, Washington University
Factors Modulating Gap Formation and Repair
Factors Modulating Gap Formation and Repair
Aura Carreira, Centro de Biologia Molecular Severo Ocha (CSIC-UAM)
Mediating Replication ssDNA Gap Prevention and Repair Through the Lenses of BRCA2
Mediating Replication ssDNA Gap Prevention and Repair Through the Lenses of BRCA2
Catherine H. Freudenreich, Tufts University
Gap-Induced Fragility at DNA Structures Revealed in a Yeast Model
Gap-Induced Fragility at DNA Structures Revealed in a Yeast Model
Coffee Break
10:00–10:20 AM
Foyer
Lunch
12:00–12:45 PM
Room 202
Posters
12:00–2:00 PM
Room 202
Symposia Spotlight 1: Short Talks Chosen from Abstracts
2:30–4:30 PM
Room 201
Gary Ying Wai Chan, The University of Hong Kong
FANCM Minimizes Single-Strand Gap Formation and Promotes PARP Inhibitor Resistance by Counteracting 53BP1
FANCM Minimizes Single-Strand Gap Formation and Promotes PARP Inhibitor Resistance by Counteracting 53BP1
So Young Joo, Seoul National University
BRCA2 at the Helm: Orchestrating Telomere G4 Dynamicity and its Impact in Ovarian Cancer
BRCA2 at the Helm: Orchestrating Telomere G4 Dynamicity and its Impact in Ovarian Cancer
Ja Yil Lee, Ulsan National Institute of Science and Technology
Alteration of RPA Binding Modes on Single-Stranded DNA by NSMF Potentiates RPA Phosphorylation by ATR Kinase
Alteration of RPA Binding Modes on Single-Stranded DNA by NSMF Potentiates RPA Phosphorylation by ATR Kinase
Junko Murai, Ehime University
SLFN11 Enhances Chemotherapeutic Sensitivity by Binding to Multiple Types of Single-Stranded DNA Gaps
SLFN11 Enhances Chemotherapeutic Sensitivity by Binding to Multiple Types of Single-Stranded DNA Gaps
Yonghwan Kim, Sookmyung Women's University
RNF4 and USP7 Coordinate Spatial Regulation of SLX4 Stability within the PML Nuclear Bodies
RNF4 and USP7 Coordinate Spatial Regulation of SLX4 Stability within the PML Nuclear Bodies
Isabelle Seppa, Washington University in Saint Louis
Mechanisms of ssDNA Gap Resection in BRCA1-Proficient and -Deficient Cells
Mechanisms of ssDNA Gap Resection in BRCA1-Proficient and -Deficient Cells
Helen E Grimsley, Memorial Sloan Kettering
The 9-1-1 Complex Protects ssDNA gaps in BRCA2-Deficient Cancer Cells To Preserve Cell Viability
The 9-1-1 Complex Protects ssDNA gaps in BRCA2-Deficient Cancer Cells To Preserve Cell Viability
Yohan An, KAIST
APOBEC3A, not APOBEC3B, Drives Deaminase-Associated Mutagenesis In Single-Stranded DNA Gaps in Human Gastric Epithelium
APOBEC3A, not APOBEC3B, Drives Deaminase-Associated Mutagenesis In Single-Stranded DNA Gaps in Human Gastric Epithelium
Coffee Available
4:30–5:00 PM
Foyer
Gaps, Cell Death and Immune Responses
5:00–7:00 PM
Room 201
Sharon B. Cantor, University of Massachusetts Chan Medical School
How the Gap Model Redefines Chemotherapy Response
How the Gap Model Redefines Chemotherapy Response
Roger Greenberg, University of Pennsylvania
Tolerance to Stress vs. Immune Induction
Tolerance to Stress vs. Immune Induction
Vanesa M. Gottifredi, Fundación Instituto Leloir
Causes and Consequences of the Choice between Template Switching, Traslesion DNA Synthesis and Repriming
Causes and Consequences of the Choice between Template Switching, Traslesion DNA Synthesis and Repriming
Hervé Técher, Université Côte d'Azur
Short Talk: MRE11 Nuclease Activity Controls Senescence by Coordinating Replication Stress And Interferon Signaling
Short Talk: MRE11 Nuclease Activity Controls Senescence by Coordinating Replication Stress And Interferon Signaling
Triparna Sen, Icahn School of Medicine at Mount Sinai
Short Talk: Intratumoral Sting Pathway Activation Enhances Anti-Tumor Immune Responses And Therapeutic Efficacy of DNA Damage Repair Inhibition
Short Talk: Intratumoral Sting Pathway Activation Enhances Anti-Tumor Immune Responses And Therapeutic Efficacy of DNA Damage Repair Inhibition
On Own for Dinner
7:00–8:00 PM
Tuesday, April 29, 2025
Breakfast
7:30–8:30 AM
Individual Hotel
Poster Setup
8:00–8:30 AM
Room 202
Poster Viewing
8:00–5:00 PM
Room 202
Visualizing and Defining the Gap Architecture
8:30–11:30 AM
Room 201
Maria Spies, University of Iowa
Structure Activity Relationships: Capturing Gap Binding Proteins in the Act with CryoEM
Structure Activity Relationships: Capturing Gap Binding Proteins in the Act with CryoEM
Katharina Schlacher, MD Anderson Cancer Center
Talk Title to be Announced
Talk Title to be Announced
Nitika Taneja, Erasmus Medical Center
Local & Spatial Chromatin Reorganization under Replication Stress
Local & Spatial Chromatin Reorganization under Replication Stress
Maximilian Donsbach, Ludwig Maximilians University Munich
Short Talk: A Non-Proteolytic Release Mechanism for HMCES-DNA-Protein Crosslinks
Short Talk: A Non-Proteolytic Release Mechanism for HMCES-DNA-Protein Crosslinks
David Szuts, HUN-REN Research Centre for Natural Sciences
Short Talk: A Genetic Delineation of Template Switching Bypass and its Role in Spontaneous Mutagenesis
Short Talk: A Genetic Delineation of Template Switching Bypass and its Role in Spontaneous Mutagenesis
Jinho Park, Stanford University
Short Talk: Dissecting the Mechanism of Repriming during DNA Damage Response Using Single-Molecule Imaging
Short Talk: Dissecting the Mechanism of Repriming during DNA Damage Response Using Single-Molecule Imaging
Annabel Quinet, CEA/Francois Jacob Institute of Biology
Short Talk: Central Role of Repriming by PRIMPOL in the Response To Replication Stress Induced By Low Doses of Genotoxic Agents
Short Talk: Central Role of Repriming by PRIMPOL in the Response To Replication Stress Induced By Low Doses of Genotoxic Agents
Coffee Break
9:30–9:50 AM
Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
Room 201
Lunch
11:30–12:30 PM
Room 202
Posters
12:00–2:00 PM
Room 202
Roundtable Discussion: Brainstorming Gap Detection Tools
2:15–3:15 PM
Room 201
Career Roundtable
3:30–4:30 PM
Room 201
Coffee Available
4:30–5:00 PM
Foyer
Gap Suppression and Avoidance Pathways in Cancer
5:00–7:00 PM
Room 201
Alberto Ciccia, Columbia University
Gap Suppression in BRCA1/2-Deficient Cells
Gap Suppression in BRCA1/2-Deficient Cells
Dale A. Ramsden, University of North Carolina
Pol Theta and the Response to Replication Stress
Pol Theta and the Response to Replication Stress
Dana Branzei, FIRC Institute of Molecular Oncology
Cohesion in Replication Stress Tolerance
Cohesion in Replication Stress Tolerance
Diego Dibitetto, Istituto di Ricerche Farmacologiche Mario Negri
Short Talk: DNA-PK Counteracts Toxic Single-Strand Breaks Accumulation and Promotes PARP Inhibitor Resistance
Short Talk: DNA-PK Counteracts Toxic Single-Strand Breaks Accumulation and Promotes PARP Inhibitor Resistance
Kei-ichi Takata, Institute for Basic Science
Short Talk: DNA Helicase HELQ Facilitates Fork Reversal in Response to Leading Strand Gaps
Short Talk: DNA Helicase HELQ Facilitates Fork Reversal in Response to Leading Strand Gaps
On Own for Dinner
7:00–8:00 PM
Wednesday, April 30, 2025
Breakfast
7:30–8:30 AM
Individual Hotel
Gaps, R-Loops and Replication Stress
8:30–11:30 AM
Room 201
Kristijan Ramadan, Nanyang Technical University
The Role of Nucleophagy in DNA Repair and Genome Stability
The Role of Nucleophagy in DNA Repair and Genome Stability
Fumiko Esashi, University of Oxford
Untangling DNA Breakage at Centromeres
Untangling DNA Breakage at Centromeres
Joanna Loizou, The Institute of Cancer Research
Talk Title to be Announced
Talk Title to be Announced
Karlene A Cimprich, Stanford University
R-Loops in Cancer
R-Loops in Cancer
Marie Sebald, The Francis Crick Insitute
Short Talk: SLX complex Promotes Okazaki Fragment Maturation in FEN1 Deficient Cells
Short Talk: SLX complex Promotes Okazaki Fragment Maturation in FEN1 Deficient Cells
Larissa Milano, University of Sussex
Short Talk: BRCA1 and BRCA2-Mediated Maturation of Nascent DNA Strands During DNA Replication
Short Talk: BRCA1 and BRCA2-Mediated Maturation of Nascent DNA Strands During DNA Replication
Coffee Break
9:30–9:50 AM
Foyer
On Own for Lunch
11:30–2:30 PM
Symposia Spotlight 2: Short Talks Chosen from Abstracts
2:30–4:30 PM
Room 201
Kyunghwan Kim, IBS
Enhanced Precision Targeting of Cancer Cells Using the CRISPR/Cas9 System and Lipid Nanoparticles
Enhanced Precision Targeting of Cancer Cells Using the CRISPR/Cas9 System and Lipid Nanoparticles
Melike Caglayan, University of Florida
Last Stop on the Road to Repair: Nick Sealing by DNA Ligase 1 and 3α
Last Stop on the Road to Repair: Nick Sealing by DNA Ligase 1 and 3α
Seung Woo Cho †, UNIST
Talk Title to be Announced
Talk Title to be Announced
Jieya Shao, Washington University in St. Louis
Moonlighting Nuclear Function of The Actin-Binding Factor Profilin-1 In ssDNA Gap Formation
Moonlighting Nuclear Function of The Actin-Binding Factor Profilin-1 In ssDNA Gap Formation
Hyunje Kang, Stanford university
Fork Reversal Prevents TRAIP-Mediated POLE1 Degradation Under Conditions of ROS
Fork Reversal Prevents TRAIP-Mediated POLE1 Degradation Under Conditions of ROS
Néstor García-Rodríguez, CABIMER/University of Sevilla
The Role of ssDNA Gap Expansion in ATR Checkpoint Activation and Synthetic Lethality in BRCA1-defcient Cells
The Role of ssDNA Gap Expansion in ATR Checkpoint Activation and Synthetic Lethality in BRCA1-defcient Cells
John J Turchi, Indiana University School of Medicine
Chemical Inhibition of RPA Gap Protection Sensitizes BRCA1-deficient Cancers to PARP Inhibition
Chemical Inhibition of RPA Gap Protection Sensitizes BRCA1-deficient Cancers to PARP Inhibition
Pauline Luise Pfuderer, University of Cambridge
Artificial Intelligence-based High-resolution Analysis of DNA Replication Dynamics on Extrachromosomal DNA
Artificial Intelligence-based High-resolution Analysis of DNA Replication Dynamics on Extrachromosomal DNA
Ronnie Low, The Francis Crick Institute
MEN1 Loss Confers Resistance to Replication Stress-Inducing Drugs
MEN1 Loss Confers Resistance to Replication Stress-Inducing Drugs
Coffee Available
4:30–5:00 PM
Foyer
Drugs Modulating and Capitalizing on a Cancer Gap Vulnerability
5:00–7:00 PM
Room 201
Orlando D Schärer, University of Pittsbrugh
Trabectedin - Targeting Tumors through Transcription-Coupled Nucleotide Excision Repair Induced DNA Gaps
Trabectedin - Targeting Tumors through Transcription-Coupled Nucleotide Excision Repair Induced DNA Gaps
Jill Bargonetti, Hunter College, City University of New York
p53 Gain of Function working together with PARP1 for Cancer Persistent Repair at Gaps
p53 Gain of Function working together with PARP1 for Cancer Persistent Repair at Gaps
Kyungjae Myung, Institute for Basic Science and UNIST
Translation of DNA Damage Including Gap for Cancer Therapy
Translation of DNA Damage Including Gap for Cancer Therapy
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–7:15 PM
Room 201
Social Hour with Lite Bites
7:15–8:00 PM
Room 202
Cash Bar
8:00–9:00 PM
Room 202
Thursday, May 1, 2025
Departure
12:00–11:59 PM
Subscribe for Updates