Proximity-Based Therapeutics: Targeted Protein Degradation and Other Pharmacological Approaches

Feb 16–19, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Philip Chamberlain and Fleur M. Ferguson

  In Person
  On Demand

Feb 16–19, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Philip Chamberlain and Fleur M. Ferguson

Available Formats:   = In Person     = On Demand
Sunday, February 16, 2025
Registration
4:00–8:00 PM
 Concourse
Welcome Mixer
6:00–8:00 PM
 Cava Santa Fe
Monday, February 17, 2025
Breakfast
7:00–8:00 AM
 Anasazi Ballroom
Poster Setup
7:30–8:00 AM
 Anasazi Ballroom
Poster Viewing
7:45–7:00 PM
 Anasazi Ballroom
Welcome and Keynote Address
8:00–9:00 AM
 Eldorado Ballroom
Benjamin F. Cravatt III, The Scripps Research Institute
Activity-Based Proteomics – Protein and Ligand Discovery on A Global Scale
Molecular and Structural Biology of Induced Proximity Drugs
9:00–11:15 AM
 Eldorado Ballroom
Brenda A. Schulman, Max Planck Institute of Biochemistry
E3-Ligase Activation, Regulation and Structure
Benjamin L. Ebert, Dana-Farber Cancer Institute
New TPD Mechanisms from Functional Genomics
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
 Concourse
Lunch
11:15–12:30 PM
 Anasazi Ballroom
Poster Session 1
12:00–2:30 PM
 Anasazi Ballroom
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
 Eldorado Ballroom
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Concourse
New Induced Proximity Approaches
5:00–7:00 PM
 Eldorado Ballroom
Gerald R. Crabtree, Stanford University
Rewiring Cancer Drivers to Activate Programmed Cell Death Pathways
Xin Zhou, Dana-Farber Cancer Institute
Novel Bifunctional Antibodies for Targeted Membrane Protein Degradation
Kevan M. Shokat, University of California, San Francisco
Proximity Approaches to Hijack Immune Signaling and Recognition
Daniel K. Nomura, University of California, Berkeley
Covalent Ligands to Drive Proximity
Short Talk(s) Chosen from Abstracts
On Own for Dinner
7:00–8:00 PM
Tuesday, February 18, 2025
Breakfast
7:00–8:00 AM
 Anasazi Ballroom
Innovation in Induced Proximity Drug Discovery
8:00–11:00 AM
 Eldorado Ballroom
William C. Forrester, Novartis
The Novartis Targeted Protein Degradation Platform
Fleur M. Ferguson, University of California, San Diego
Interrogating the Druggable Proteome with Proximity Pharmacology
Philip Chamberlain, Neomorph, Inc.
Talk Title to be Announced
Anil Vasudevan, AbbVie, Inc.
The Hunt for Ligands for Tissue-Restricted Ligases
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Concourse
On Own for Lunch
11:00–5:00 PM
Poster Setup
11:00–1:00 PM
 Anasazi Ballroom
Poster Viewing
1:00–10:00 PM
 Anasazi Ballroom
Career Roundtable
3:00–4:30 PM
 Eldorado Ballroom
Coffee Available
4:30–5:00 PM
 Concourse
Clinical Progress in Proximity Technologies
5:00–7:00 PM
 Eldorado Ballroom
Danette L. Daniels, Foghorn Therapeutics, Inc
Clinical Progress in Degrading Epigenetic Disease Drivers
Michael Pourdehnad, Bristol-Myers Squibb
Clinical Advances in Cereblon-based Heterobifunctional and Glue Degraders
Juliet Williams, Kymera Therapeutics
Clinical Updates on PROTACS in Immunology and Oncology
Short Talk(s) Chosen from Abstracts
Social Hour with Lite Bites
7:00–8:00 PM
 Anasazi Ballroom
Poster Session 2
7:30–10:00 PM
 Anasazi Ballroom
Wednesday, February 19, 2025
Breakfast
7:00–8:00 AM
 Anasazi Ballroom
Beyond Degradation: New Applications of Induced Proximity
8:00–11:00 AM
 Eldorado Ballroom
Cristina Mayor-Ruiz, IRB Barcelona
Chasing Molecular Glue Degraders
Amit Choudhary, Harvard Medical School
Talk Title to be Announced
Michelle R. Arkin, University of California, San Francisco
Hacking Native Protein-Protein Interaction Networks with Molecular Glues
Francesca Ester Ester Morreale, Francis Crick Institute
Enabling Targeted Protein Degradation in Bacteria
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
 Concourse
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
 Eldorado Ballroom
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
 Concourse
Hijacking New Components of the Degradation Machinery
5:00–7:00 PM
 Eldorado Ballroom
Stefan Knapp, SGC Frankfurt
E3-Ligases and updates from the SGC
Natalie Scholes, CeMM
When Inhibitors Act as Degraders: Supercharging Protein Turnover via Endogenous Degradation Routes
Henry M. Colecraft, Columbia University
Hacking the Polyubiquitin Code to Understand and Manipulate Ion Channel Functional Expression
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
 Eldorado Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
 Anasazi Ballroom
Entertainment
8:00–9:00 PM
 Eldorado Ballroom
Cash Bar
8:00–9:00 PM
 Anasazi Ballroom
Thursday, February 20, 2025
Departure
12:00–11:59 PM

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