Epigenetic Mechanisms and Cancer Treatment
February 4-7, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:
Tony Kouzarides, Rab K. Prinjha and Marisa S. Bartolomei
In Person
On Demand
February 4-7, 2024 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:
Tony Kouzarides, Rab K. Prinjha and Marisa S. Bartolomei
Available Formats:
In Person
On Demand
Supported by the Directors' Fund
Available Formats: = In Person = On Demand
Merchandise Options
Registration Options
Booking Function
Fundraising
Sunday, February 4, 2024
Arrival and Registration
4:00–8:00 PM
Concourse
Welcome Mixer
6:00–8:00 PM
Cava Santa Fe
Monday, February 5, 2024
Breakfast
7:00–8:00 AM
Anasazi Ballroom
Poster Setup
7:30–8:00 AM
Anasazi Ballroom
Poster Viewing
8:00–7:00 PM
Anasazi Ballroom
Welcome and Keynote Address
8:00–9:00 AM
Eldorado Ballroom
* Tony Kouzarides, University of Cambridge
Session Chair
Session Chair
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Health and Disease
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Health and Disease
Targeting Epigenetic Pathways in Cancer
9:00–11:15 AM
Eldorado Ballroom
* Ali Shilatifard, Northwestern University
Session Chair
Session Chair
Ali Shilatifard, Northwestern University
Principles of Epigenetics and Chromatin in Development and Human Disease
Principles of Epigenetics and Chromatin in Development and Human Disease
Mark A. Dawson, Peter MacCallum Cancer Centre
Targeting the Epigenome for Therapeutic Gain
Targeting the Epigenome for Therapeutic Gain
Tony Kouzarides, University of Cambridge
Disruption of RNA Modification Pathways in Cancer
Disruption of RNA Modification Pathways in Cancer
Andrew Muntean, University of Michigan
Short Talk: The YEATS Domain Impacts MLL-ENL Leukemic Stem Cell Frequency through Transcriptional Target Recognition
Short Talk: The YEATS Domain Impacts MLL-ENL Leukemic Stem Cell Frequency through Transcriptional Target Recognition
Coffee Break
9:30–9:50 AM
Concourse
Lunch
11:30–12:30 PM
Anasazi Ballroom
Poster Session 1
12:00–2:30 PM
Anasazi Ballroom
Career Roundtable
3:00–4:30 PM
Kimberly Stegmaier, Dana-Farber Cancer Institute
Professor & Attending Physician
Professor & Attending Physician
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
Professor
Professor
Philippe Slos, Boehringer Ingelheim
Principal Scientist
Principal Scientist
Coffee Available
4:30–5:00 PM
Concourse
Targeting Transcription in Cancer
5:00–7:00 PM
Eldorado Ballroom
* Karen Adelman, Harvard Medical School
Session Chair
Session Chair
Kristian Helin, The Institute of Cancer Research
Epigenetic Regulation of Transcription
Epigenetic Regulation of Transcription
Karen Adelman, Harvard Medical School
Rewiring of Transcriptional Enhancers in Cancer and in Response to Therapeutics
Rewiring of Transcriptional Enhancers in Cancer and in Response to Therapeutics
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
Compartmentalisation and Gene Interplay in Transcription
Compartmentalisation and Gene Interplay in Transcription
Zuzana Tothova, Dana-Farber Cancer Institute
Short Talk: Cohesin Complex Regulates R-loop Resolution and Drives Development of Myeloid Malignancies
Short Talk: Cohesin Complex Regulates R-loop Resolution and Drives Development of Myeloid Malignancies
Nils Cordes, Helmholtz-Zentrum
Short Talk: Chromatin Architecture and Gene Expression are Critically Co-regulated by α7 Integrin in Head and Neck Cancer
Short Talk: Chromatin Architecture and Gene Expression are Critically Co-regulated by α7 Integrin in Head and Neck Cancer
On Own for Dinner
7:00–8:00 PM
Tuesday, February 6, 2024
Breakfast
7:00–8:00 AM
Anasazi Ballroom
Chromatin Structure and Regulation
8:00–11:00 AM
Eldorado Ballroom
* Robert E. Kingston, Massachusetts General Hospital
Session Chair
Session Chair
Robert E. Kingston, Massachusetts General Hospital
Nucleosome Compaction and Phase Transition in Repression
Nucleosome Compaction and Phase Transition in Repression
Shelley L. Berger, University of Pennsylvania
Epigenetic Enzymes and their Miss-Function in Disease
Epigenetic Enzymes and their Miss-Function in Disease
Anne C. Ferguson-Smith, University of Cambridge
The Genetics of Epigenetic Variation
The Genetics of Epigenetic Variation
Vincent van den Boom, University Medical Center Groningen
Short Talk: USP7 Inhibition Impacts on PRC1.1-mediated Gene Control through Increased Ubiquitination of PRC1.1 Subunits and Reduces Primary AML Cell Viability
Short Talk: USP7 Inhibition Impacts on PRC1.1-mediated Gene Control through Increased Ubiquitination of PRC1.1 Subunits and Reduces Primary AML Cell Viability
Adrian P. Bracken, Trinity College Dublin
Short Talk: Specific cPRC1 Complexes are co-opted to Mediate Oncogenic Gene Repression in H3K27M-mutant Diffuse Midline Glioma
Short Talk: Specific cPRC1 Complexes are co-opted to Mediate Oncogenic Gene Repression in H3K27M-mutant Diffuse Midline Glioma
Coffee Break
9:00–9:20 AM
Concourse
On Own for Lunch
11:00–5:00 PM
Poster Setup
11:00–1:00 PM
Anasazi Ballroom
Poster Viewing
1:00–10:00 PM
Anasazi Ballroom
Workshop 1
2:30–4:30 PM
Eldorado A
* Yael David, Memorial Sloan Kettering Cancer Center
Session Chair
Session Chair
Giovanni Gambi, NYU Grossman School of Medicine
3D Chromatin Hubs as Regulatory Units of Identity and Survival in Human Acute Leukemia
3D Chromatin Hubs as Regulatory Units of Identity and Survival in Human Acute Leukemia
Dorelle V Fawwal, Emory University
Characterizing the Oncogenic Impact of Novel H2B Variants
Characterizing the Oncogenic Impact of Novel H2B Variants
Akshay Sanghi, Stanford University
Chromatin Accessibility Associates with Protein-RNA Correlation in MAPK-driven Cancer
Chromatin Accessibility Associates with Protein-RNA Correlation in MAPK-driven Cancer
Zhen Sun, Memorial Sloan Kettering Cancer Center
Chromatin Regulation of Transcriptional Enhancers and Cell Fate by the Sotos Syndrome Gene NSD1
Chromatin Regulation of Transcriptional Enhancers and Cell Fate by the Sotos Syndrome Gene NSD1
Kishore R Akhouri, Dana-Farber Cancer Institute
Context-Dependent SOX9 Interactions with Components of BAF Complexes in Colon Neoplasia
Context-Dependent SOX9 Interactions with Components of BAF Complexes in Colon Neoplasia
Joanna Vuille, Cancer Center, Krantz Family Center for Cancer Research, Mass General Hospital
DNA Hypomethylation Silences Anti-tumor Immune Genes in Early Prostate Cancer and CTCs
DNA Hypomethylation Silences Anti-tumor Immune Genes in Early Prostate Cancer and CTCs
Diana Chin, Case Western Reserve University
Epigenetic Drivers of Osteosarcoma Metastasis
Epigenetic Drivers of Osteosarcoma Metastasis
Coffee Available
4:30–5:00 PM
Concourse
Mechanisms of RNA and DNA Modulation in Cancer
5:00–7:15 PM
Eldorado Ballroom
* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine
Session Chair
Session Chair
Ramin Shiekhattar, University of Miami
RNA Processing by the Integrator-Complex and Its Role in Cancer
RNA Processing by the Integrator-Complex and Its Role in Cancer
François Fuks, Université Libre de Bruxelles
Mapping and Function of RNA Modifications in Cancer
Mapping and Function of RNA Modifications in Cancer
Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine
DNA Methylation in Reprogramming
DNA Methylation in Reprogramming
Andrea Piunti, University of Chicago
Short Talk: CATACOMB Prevents PRC2 Mediated Transcriptional Repression Upon DNA hypomethylation
Short Talk: CATACOMB Prevents PRC2 Mediated Transcriptional Repression Upon DNA hypomethylation
Social Hour with Lite Bites
7:00–8:00 PM
Anasazi Ballroom
Poster Session 2
7:30–10:00 PM
Anasazi Ballroom
Wednesday, February 7, 2024
Breakfast
7:00–8:00 AM
Anasazi Ballroom
Epigenetic Drug Discovery in Cancer
8:00–11:00 AM
Eldorado Ballroom
* Rab K. Prinjha, GlaxoSmithKline
Session Chair
Session Chair
Rab K. Prinjha, GlaxoSmithKline
Translating Novel Epigenetic Drugs into the Clinic
Translating Novel Epigenetic Drugs into the Clinic
Helai P. Mohammad, SK Life Science Labs
Degradation of Epigenetic Machinery for the Treatment of Cancer
Degradation of Epigenetic Machinery for the Treatment of Cancer
Tamara Maes, Oryzon Genomics
Identifying an Effective Team: Optimizing Combo Treatments With the LSD1 Inhibitor Iadademstat for Oncological Indications
Identifying an Effective Team: Optimizing Combo Treatments With the LSD1 Inhibitor Iadademstat for Oncological Indications
Camiel Göbel, Netherlands Cancer Institute
Short Talk: Combined Epi-drugging as a Novel Treatment Modality for Diffuse Large B Cell Lymphoma
Short Talk: Combined Epi-drugging as a Novel Treatment Modality for Diffuse Large B Cell Lymphoma
Brian C. Capell, University of Pennsylvania
Short Talk: Disruption of H3K36 Methylation Provokes Cellular Plasticity to Drive Aberrant Glandular Formation and Squamous Carcinogenesis
Short Talk: Disruption of H3K36 Methylation Provokes Cellular Plasticity to Drive Aberrant Glandular Formation and Squamous Carcinogenesis
Adam D Durbin, St. Jude Children's Research Hospital
Short Talk: Group 3 Medulloblastoma Transcriptional Networks Collapse Under Domain-specific EP300/CBP Inhibition
Short Talk: Group 3 Medulloblastoma Transcriptional Networks Collapse Under Domain-specific EP300/CBP Inhibition
Coffee Break
9:00–9:20 AM
Concourse
On Own for Lunch
11:00–5:00 PM
Workshop 2
2:30–4:30 PM
Eldorado A
* Adrian P. Bracken, Trinity College Dublin
Session Chair
Session Chair
Isaac F. López-Moyado, La Jolla Institute for Immunology
Exacerbated Accumulation of R-loops Impairs the Proliferation of TET-deficient Cells
Exacerbated Accumulation of R-loops Impairs the Proliferation of TET-deficient Cells
Samah W. Awwad, University of Cambridge
KLF5 Loss Sensitizes to ATR Inhibition and is Synthetic Lethal with ARID1A-Deficiency
KLF5 Loss Sensitizes to ATR Inhibition and is Synthetic Lethal with ARID1A-Deficiency
Gregory Marshall, Rutgers University
Loss of KDM5C Promotes Immune Escape in Kidney Cancer
Loss of KDM5C Promotes Immune Escape in Kidney Cancer
Darko Barisic, Weill Cornell Medicine
Mammalian SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Transcription Factors and Restricts Malignant Transformation
Mammalian SWI/SNF Chromatin Remodeling Complex Orchestrates Sequential Binding of Transcription Factors and Restricts Malignant Transformation
Rebecca Starble, Yale University
METTL7A Promotes Osimertinib Resistance by Regulating Chromatin Architecture and Driving Oncogene Amplification
METTL7A Promotes Osimertinib Resistance by Regulating Chromatin Architecture and Driving Oncogene Amplification
Joseph Hsieh, University of Colorado Anschutz
Dependence of PAX3-FOXO1 Chromatin Occupancy on ETS1 Exposes New Targetable Vulnerability in Fusion-Positive Rhabdomyosarcoma
Dependence of PAX3-FOXO1 Chromatin Occupancy on ETS1 Exposes New Targetable Vulnerability in Fusion-Positive Rhabdomyosarcoma
Qi Jiang, University of Pittsburgh
Synergistic Targeting of NuRD Complex and Proteostasis to Eradicate Quiescent Ovarian Cancer Cells
Synergistic Targeting of NuRD Complex and Proteostasis to Eradicate Quiescent Ovarian Cancer Cells
Ilaria Panzeri, Van Andel Institute
Developmental Priming of Cancer Risk
Developmental Priming of Cancer Risk
Coffee Available
4:30–5:00 PM
Concourse
Epigenetics in Diagnosis and Treatment of Cancer
5:00–6:45 PM
Eldorado Ballroom
* Kimberly Stegmaier, Dana-Farber Cancer Institute
Session Chair
Session Chair
Kimberly Stegmaier, Dana-Farber Cancer Institute
Treatments in Pediatric Oncology
Treatments in Pediatric Oncology
Yael David, Memorial Sloan Kettering Cancer Center
Short Talk: Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Non-Canonical Chromatin Species
Short Talk: Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Non-Canonical Chromatin Species
Huijue Lyu, Northwestern University
Short Talk: GATA6 is a Novel Regulator of Gene Expression and 3D Genome in Colorectal Cancer
Short Talk: GATA6 is a Novel Regulator of Gene Expression and 3D Genome in Colorectal Cancer
H. Courtney Hodges, Baylor College of Medicine
Short Talk: Reactivation of the G1 Enhancer Landscape Underlies Core Circuitry Addiction to SWI/SNF
Short Talk: Reactivation of the G1 Enhancer Landscape Underlies Core Circuitry Addiction to SWI/SNF
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Eldorado Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
Anasazi Ballroom
Trivia and Hosted Bar
8:00–9:00 PM
Eldorado Ballroom
Thursday, February 8, 2024
Departure
7:00–11:59 PM
Subscribe for Updates