The gut and brain interact to control a host of behaviors (including feeding), gut function, the perception of gastrointestinal malaise, and many autonomic responses. Most of these responses are mediated at the level of the brainstem, which also represents the site for many feeding-related actions of incretin-mimetics. Understanding the systems that sense gut status and respond to incretin mimetics, as well as the defining circuits that process and relay these signals to promote specific behavioral and autonomic outputs may reveal potential targets for therapeutic intervention in obesity. This meeting will focus on the gut systems and neural circuits by which the gut and brain communicate to effect behavioral and physiologic changes. The conference will provide a venue to learn about, discuss, and integrate the latest research advances regarding the sensing of information by the gut, the relay of this information to the brain, the mechanisms and circuits that mediate ensuing behavioral and physiologic changes, and the systems that mediate anti-obesity actions of incretin-mimetics, as well as examining the integration of gut-brain signaling with islet biology. The conference will integrate academic and industry perspectives, providing the opportunity for interdisciplinary discussions that can drive therapeutic advances. Workshops will focus on emerging areas of research and technology, as well as career development. The meeting will engage researchers from diverse areas of expertise, integrating neuroscience, gut biology, metabolism, behavior, physiology, nutrition, and pharmacology, allowing participants to comprehensively understand mechanisms of gut-brain communication and the importance of these mechanisms for physiology, pathophysiology, and therapy.