Tumor evolution is a process by which cells acquire genetic and epigenetic alterations that lead to inappropriate cell proliferation. This process is fueled further by extensive interactions between cancer cells and cells of the tumor microenvironment, including immune cells and fibroblasts. In recent years, there has been a great deal of attention focused on the tumor microenvironment and signaling between different cell types within the tumor. Here we aim to draw attention back to the cancer cell itself to think about the cell intrinsic mechanisms that promote tumor development. This focus will not only provide a deeper understanding of the underpinnings of carcinogenesis but also provide new insights into potential strategies for therapeutic interventions. The sessions are intended to cover broad topics ranging from tumor evolution, tumor heterogeneity, and metabolic rewiring and plasticity to drugging cancer cell-intrinsic pathways and cancer cell vulnerabilities. A session at the end of the meeting will focus on emerging topics and unanswered questions in the field. The audience will include established scientists in the field, from academia, industry and the clinic, as well as trainees at multiple levels, including postdoctoral fellow and graduate students.  As the goal of the meeting is to stimulate thinking about changes in cancer cells themselves during the process of tumor evolution, this meeting is distinct from many meetings in the cancer field, which focus much more on crosstalk between various cell types in the tumor. Attendees will thus take away a broad-based overview of the field that is uniquely focused on the cancer cell itself, a critical perspective for both understanding tumor evolution and for designing better cancer therapies.