Emerging evidence supports the role of the neuro-immune axis as a determinant of the onset and progression of neurological diseases. This Symposium focuses on the latest advances in understanding how neuroimmune functions affect cognition, autoimmunity, and neurodegeneration in the CNS. The Symposium will intersect scientific areas of microglial biology, the blood-brain barrier, neurogenesis, cognitive decline, aging, neurological diseases and psychiatric disorders. Emphasis will be placed on innovative technologies including multiomics, state-of-the-art imaging technologies, and genome engineering that drive basic discoveries and therapeutics. The Symposium will explore the convergence of diverse pathways to regulate the neuro-immune axis and determine their contribution to brain physiology and pathology. The Symposium will feature novel therapeutic strategies targeting neuroimmune mechanisms in neurological diseases. The ultimate goal of this Symposium would be to inspire creative ideas and promote multidisciplinary collaborations for studying CNS function and dysfunction and harnessing the immune system for drug discovery for devastating neurological diseases. The Symposium is designed to foster the exchange of ideas from across fields, thus providing a novel way to think about neurologic disease. We are bringing together a highly diverse group of speakers, who normally would not have an opportunity to meet, with a wide range of expertise ranging from regulation of neuronal activity and glial cell biology, to metabolomics and neurovascular interactions, adaptive and innate immunity. The meeting will highly benefit from being held jointly with the Neurodegeneration Symposium, as neuroimmune mechanisms underlying neurological diseases will be discussed including multiple sclerosis, Alzheimer’s disease, and brain trauma.