The deadline to submit an abstract for short talk and poster presentation consideration has passed.  For any questions or issues, please email info@keystonesymposia.org.

Over 3 decades ago, Charles Janeway predicted pathogen sensing was mediated by germline-encoded pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs). Since then, a multitude of endosomal and cytoplasmic sensors, their ligands and downstream signal transduction pathways that initiate innate immunity have been defined. Emerging techniques such as cellular and spatial transcriptomics are informing us where in the human body, and in what diverse disease contexts, these pattern recognition receptors (PRRs), and associated gene circuits, are implicated. Furthermore, metabolic and chromatin analyses are illuminating acute and chronic adaptation of innate immune cell transcriptional programs. The next frontier in innate immunity will be understanding how innate sensor-ligand interactions, and the individual cellular programs that ensue, work in complex systems of tissue and microorganismal microenvironments. Of particular importance will be grasping innate immunity resolution during homeostasis and how it can be leveraged, or avoided, for treatment of infectious, autoimmune, neurodegenerative, cardiovascular and oncological diseases.

This conference will provide multidisciplinary perspectives on new horizons and the unexpected in innate immunity. The program will highlight innovative techniques and novel read outs of innate immunity at the molecular, cellular and tissue level to place importance of innate immunity in human health. We will also take a deep dive into clinical aspects of disease and contemporary drug discovery approaches to harness for innate immune modulation. This meeting will be a unique forum for researchers from diverse and traditionally non-overlapping fields (immunology, metabolism, artificial intelligence, drug discovery, structural biology), to build fresh ideas and collaborations for the next chapter of innate immune discovery and translation. The conference will be held jointly with the Keystone Symposium  on Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease, to enable cross-disciplinary insights and collaborations towards utilization of systems immunology tools to advance our understanding of innate immunity in health and disease.

Meeting co-organizer Dr. Kate Jeffrey talks about why you should attend this meeting in the video below: