The covalent attachment of ubiquitin to target proteins plays a central role in regulating a vast array of processes in eukaryotic cells. Building upon seminal work elucidating the role of ubiquitination in proteostasis as well as the mechanisms underlying the ubiquitin enzyme cascade, ongoing studies have revealed an expanded regulatory role for ubiquitin and ubiquitin-like proteins, as well as variations in the ubiquitin conjugation machinery.

This conference will bring together researchers from academia and industry to share the latest research into the role of ubiquitin family of proteins in different biological pathways, the mechanisms underlying novel roles for ubiquitin, and the development of new therapeutic strategies targeting the ubiquitin-proteasome system. There will be sessions devoted to the dynamics and specificity of the ubiquitin system, insights into the mechanisms by which ubiquitin is conjugated to biological molecules, regulatory roles of ubiquitin in health and disease, and novel approaches to targeting the ubiquitin system. Workshops featuring talks selected from abstracts will provide a forum for sharing late-breaking results and opportunities for junior investigators to feature their work. Joint sessions with the meeting on Autophagy and Disease will foster new connections and collaborations that will mutually advance the ubiquitin and autophagy fields.