This meeting will investigate the critical yet underexplored intersectionality of metabolic and immune processes at all biological levels, and their interplay in health and disease. The program will illuminate the uncharted territories of immunometabolism, from cellular mechanisms to system-wide impacts. Specifically, the program will address the intricacies of nutrient signaling, the pivotal role of microbial metabolites in modulation of nutrition and immunity, and the immune system's adaptive mechanisms across varied metabolic ecosystems and in the context of neuro-immune interactions. We will explore how immunometabolic mechanisms influence overall systemic metabolism, as well as how these processes govern aging and contribute to diseases of aging. These mechanistic insights will provide insight into translational strategies for clinical interventions aimed at enhancing healthspan.

By bringing these fields together, this meeting will catalyze robust collaborative networks that integrate metabolic and immune expertise across current siloes, to yield novel cross-disciplinary insights and research directions. The cross-pollination will also provide opportunity for methodology sharing, and innovation in tools to advance this rapidly evolving field.  Attendees will leave with enriched perspectives and ready to implement advanced techniques and new approaches to their own research. Upon conclusion of this meeting the field of immunometabolism will be poised to shift towards a more integrated approach to leveraging immunity and metabolism to ultimately pave the way for novel intervention to increase healthspan.

Additionally, this meeting will be held jointly with the Keystone Symposium on “From Systems Immunology to Immunoengineering,” to enable cross-disciplinary insights and collaborations towards utilizing systems biology approaches to better understand the complexities of immunometabolic mechanisms and contributions to disease.