Fairmont Banff Springs Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

NOTES:
This meeting will be conducted in English.

All programs are subject to change. Check this site for updates.


Download Flyer

Twitter hashtag for this meeting: #KSifn

Type I Interferon: Friend and Foe Alike (X6)

joint with the meeting on Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease (X5)

Scientific Organizers: Alan Sher, Virginia Pascual, Adolfo García-Sastre and Anne O'Garra


March 19—23, 2017

Fairmont Banff Springs, Banff, Alberta, Canada


Supported by the Directors' Fund


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

DEADLINES:
Scholarship Deadline: Nov 17, 2016 [details]
Discounted Abstract Deadline: Nov 17, 2016 [details]
Abstract Deadline: Dec 20, 2016 [details]
Discounted Registration Deadline: Jan 19, 2017 [details]

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2017-X6 "Type I Interferon: Friend and Foe Alike" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On November 17, 2016 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After November 17, 2016 until February 14, 2017 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
November 17, 2016 n/a
Discounted NON-STUDENT Registration
More details
Before and On January 19, 2017 845.00 USD
(includes 150.00 discount)
Regular NON-STUDENT Registration
More details
After January 19, 2017 995.00 USD
Discounted STUDENT Registration
More details
Before and On January 19, 2017 620.00 USD
(includes 150.00 discount)
Regular STUDENT Registration
More details
After January 19, 2017 770.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: November 17, 2016


Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is December 20, 2016)

Global Health Travel Award Deadline:


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: November 17, 2016


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: December 20, 2016


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is November 17, 2016)

Discounted Registration Deadline: January 19, 2017


Registration Fee: 845.00 USD* (includes 150.00 USD discount)
Student Registration Fee: 620.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 995.00 USD*
Student Registration Fee: 770.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 24 in order to fully experience the meeting.

SUNDAY, MARCH 19

16:00—20:00
Arrival and Registration

Van Horne Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, MARCH 20

07:00—08:00
Breakfast

Mezzanine 2
08:00—09:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

* Alan Sher, NIAID, National Institutes of Health, USA

Anne O'Garra, Francis Crick Institute, UK
Type I IFN Regulation of Cytokine Networks and Consequences for Infection

Daniel Kastner, National Institutes of Health, USA
PRR Signaling and Inflammatory Disease

Coffee Break

09:50—12:15
Nucleic Acid Recognition Pathways Regulating Type I IFN Induction (Joint)
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Cytosolic Recognition of DNA through cGAS/STING Pathway

Sun Hur, Harvard Medical School, USA
Cytosolic Sensing of Viral RNA by the RIG-I-Like Receptors

Gregory M. Barton, University of California, Berkeley, USA
Endosomal Recognition of Self-Nucleic Acids

Vishva M. Dixit, Genentech, Inc., USA
Inflammasome Signaling

12:15—14:30
On Own for Lunch

12:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 1: Innate Signals for Type I IFN Induction

Van Horne C
* Paul J. Hertzog, Hudson Institute of Medical Research, Australia

* Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA

John Ty Crowl, University of Washington, USA
Loss of Sumoylation Triggers a Spontaneous Type I Interferon Response Independent of Cytosolic Nucleic Acid Sensing Pathways

Martin R. Jakobsen, Aarhus University Faculty of Health Science, Denmark
IFI16 Dictates DNA Sensing in Human Macrophages by Promoting Production and Function of cGAMP

Stefanie Luecke, Aarhus University, Denmark
Length-Dependent Sensing of Low-Abundance dsDNA by cGAS

Jennifer Lumb, Stanford University, USA
Unbiased Haploid Genetic Screen Uncovers a Novel RNA Binding Immune Regulator

Nathalie M. Grandvaux, Université de Montréal, Canada
Characterization of a Delayed Transcriptional Program Induced in Response to the Synergistic Action of IFNBeta+TNFalpha Reveals Novel STAT2 and IRF9-Dependent Pathways

Jennie B. Altman, Icahn School of Medicine at Mount Sinai, USA
Non-Canonical Type I IFN Signaling in ISG15-/- and USP18-/- Cells

Antje Blumenthal, University of Queensland, Australia
Spatiotemporal Regulation of TLR4 Signaling and Promotion of Type I IFN Responses by the RP105-PI3K p110delta Innate Immune Signaling Axis

Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Ppp1r15a/GADD34 Controls Heterogeneity of Type-I Interferon Production in Response to dsRNA

14:30—16:30
Workshop 1: PRRs in Inflammatory Diseases

Van Horne A/B
* Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA

* Eicke Latz, University of Bonn, Germany

Sreya Ghosh, University of Massachusetts Medical School, USA
The PYHIN Protein IFI205 Regulates Immune Signaling by Controlling Expression of the Inflammasome Adaptor ASC

Mena Abdel-Nour, University of Toronto, Canada
The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Innate Immune Receptors

José Santos, University of Basel, Switzerland
Novel GBP-Dependent Mechanisms of Inflammasome Activation

Matthew James George Eldridge, Imperial College London, UK
The Atypical Ubiquitin E2 Conjugase UBE2L3 is an Indirect Caspase-1 Target and controls IL-1Beta Secretion by Inflammasomes

Nidhi Jain, Cedars-Sinai Medical Center, USA
NLRP12 Mutation Causes C57BL/6J Strain-Specific Defect in Neutrophil Recruitment

Nina Van Opdenbosch, VIB-University of Ghent, Belgium
Defective Caspase-1 Recruitment Licenses ASC Specks to Engage Non-Inflammatory Caspase-8-Driven Apoptosis in Macrophages and Intestinal Epithelial Cells

Charlotte Macleod, University of Cambridge, UK
Determining the Stoichiometry of the TLR-4 Adaptor Protein Mal/TIRAP using TIRF Microscopy

Scott W. Canna, Children's Hospital of Pittsburgh, University of Pittsburgh, USA
Chronic IL-18 of Diverse Origins Defines and Drives the Hyperinflammatory State Known as Macrophage Activation Syndrome

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Mendelian Interferonopathies and IFN-Deficiencies
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Virginia Pascual, Baylor Research Institute, USA

Dusan Bogunovic, Icahn School of Medicine at Mount Sinai, USA
Loss of Type I Interferon Negative Regulation in Humans

Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Defective Intracellular Nucleic Acid Waste Management in Type 1 Interferon-Driven Autoinflammation and Autoimmunity

Raphaela Theresia Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA
Novel Insights into the Pathogenesis and Treatment Approaches of the Type I-IFN-Mediated Autoinflammatory Diseases, CANDLE and SAVI

Joaquín M. Espinosa, University of Colorado Boulder, USA
Short Talk: Trisomy 21 Consistently Activates the Interferon Response: Understanding Down Syndrome as an Interferonopathy

17:00—19:00
Nucleic Acids in TLR and NLR Signaling
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Mohamed Lamkanfi, Ghent University, Belgium

Jonathan C. Kagan, Boston Children's Hospital, USA
Initiation and Regulation of Innate Immune Signal Transduction

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Novel Regulators of PRR-Driven Transcriptional Responses

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasomes and Pathogen Sensing

Osamu Takeuchi, Institute for Virus Research, Kyoto University, Japan
Short Talk: Spatiotemporal Regulation of Inflammatory mRNAs in Innate Immune Responses

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

TUESDAY, MARCH 21

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Type I IFN Regulation of Viral Infection and Cancer
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Ana Fernandez-Sesma, Mount Sinai School of Medicine, USA
Modulation of Innate Immunity by Dengue Virus: Feeling the STING

Andreas Wack, National Institute for Medical Research, The Francis Crick Institute, UK
Unique and Overlapping Roles of Type I and Type III Interferons in Influenza Infection

Coffee Break

John W. Schoggins, University of Texas Southwestern Medical Center, USA
Cell Intrinsic Modulation of Viral and Bacterial Infection by IFN-Stimulated Genes

Thomas J. Braciale, University of Virginia, USA
Innate Immune Control of Respiratory Virus Infection

Gaya Amarasinghe, Washington University School of Medicine, USA
Short Talk: Control of Type I IFN Signaling in Negative Sense RNA Viruses

Jason Waithman, Telethon Kids Institute, Australia
Short Talk: IFNalpha Subtypes Drive Distinct Anti-Cancer Activities

08:00—11:15
Recent Insights in Inflammasome Signaling
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Vishva M. Dixit, Genentech, Inc., USA

Fayyaz Sutterwala, Cedars-Sinai Medical Center, USA
Cardiolipin Promotes Mitochondrial Localization of NLRP3 and Caspase-1

John Bertin, GlaxoSmithKline, USA
RIPK1 Therapeutics: From Concept to Patients

Coffee Break

Kim Newton, Genentech, USA
Regulation of Inflammation and Cell Death by RIPK1

Feng Shao, National Institute of Biological Sciences, China
Pyroptosis in Anti-Bacterial Immunity: Sensing & Execution

Bharat Behl, University of Connecticut Health Center, USA
Short Talk: Molecular Determinants of Noncanonical Inflammasome Activation by LPS

Olaf Groß, TU München, Germany
Short Talk: Caspase-1 Mutant Mouse Reveals a Central Role of Caspase-1 Protease Activity and GSDMD in Fate Decisions After Inflammasome Activation

11:15—14:30
On Own for Lunch

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
14:30—16:30
Workshop 2: Role of Type I IFNs in Control and Enhancement of Infection

Van Horne C
* Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA

* Thomas J. Braciale, University of Virginia, USA

Charles S. Dela Cruz, Yale University, USA
Chitinase-Like Protein Chi3l1 Modulates Type I Interferon Response through TLR9-AP3-IRF7 Axis during Streptococcus Pneumoniae Lung Infection

Ren Sun, University of California, Los Angeles, USA
Genome-Wide Identification of Anti-Interferon Functions in Influenza A Virus

Lindsey Cook, Washington University in St. Louis, USA
Differential Roles of Type I Interferons in Chikungunya Virus Infection

Bastian Opitz, Charité University Medicine Berlin, Germany
A Common Loss-of-Function Variant of STING Affects cGAS-Dependent Antibacterial Defense

Laura Sinigaglia, Institut Pasteur, France
Transfer of Yellow Fever Virus RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Interferon Production

Nick Parekh, Penn State College of Medicine, USA
cGAS Mediates a Protective Local Response to Dermal Vaccinia Infection Independent of Control of Virus Replication

14:30—16:30
Workshop 2: PRRs in Inflammatory Diseases

Van Horne A/B
* Dmitry M. Shayakhmetov, Emory University, USA

* Denise M. Monack, Stanford University, USA

Marcia A. Munoz, Garvan Institute of Medical Research, Australia
Defective Protein Prenylation Is a Diagnostic Biomarker for Mevalonate Kinase Deficiency

T. Sam Xiao, Case Western Reserve University, USA
Structures of GSDMD C-Terminal Domain Suggest Mechanisms of Autoinhibition

Igor E. Brodsky, University of Pennsylvania, USA
Role of Caspase-8 Enzymatic Activity in Control of TLR-Induced Macrophage Gene Expression

Damien Arnoult, Hopital Paul Brousse, France
The Golgi Apparatus Acts as a Platform for TBK1 Activation After Viral RNA Sensing

Randilea Nichols, University of California, Berkeley, USA
NLRC4 Inflammasome Activation in Neutrophils is Sufficient to Cause Systemic Inflammatory Disease

Rosalie Heilig, University of Basel, Switzerland
The Role of Gasdermin D in IL-1Beta Release

Jewook Yu, Yonsei University College of Medicine, South Korea
25-hydroxycholesterol Contributes to Cerebral Inflammation of X-linked Adrenoleukodystrophy (X-ALD) through Activation of the NLRP3 Inflammasome

Cindy Chiang, University of Chicago, USA
The Human Papillomavirus E6 Oncoprotein Inhibits TRIM25- and RIG-I-Mediated Innate Immune Signaling

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Type I IFN Regulation of Viral Infection
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Andreas Wack, National Institute for Medical Research, The Francis Crick Institute, UK

Netanya Sandler Utay, University of Texas Medical Branch at Galveston, USA
Type I Interferons: Barrier or Pathway to HIV Disease?

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Regulation of Influenza Virus Sensing and Antiviral Responses by Host and Virus Factors

Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Interactions of Cellular Proteins with Viral Nucleic Acids

Ricardo Rajsbaum, University of Texas Medical Branch, USA
Short Talk: Friend and Foe in the Regulation of IFN Pathways: Pro-Viral and Anti-Viral Functions of the Host E3-Ubiquitin Ligase TRIM6

17:00—19:00
Interfering with Pathogenic TLR and NLR Signaling
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Gabriel Nuñez, University of Michigan, USA

Dana Philpott, University of Toronto, Canada
Nod2 Signaling

Dmitry M. Shayakhmetov, Emory University, USA
Non-canonical Regulated Necrotic Death and Sensing Danger

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Intracellular Innate Immune Receptors: Regulators of Inflammation, Cancer and Immunity

Vikram R. Rao, Pfizer, USA
Short Talk: IRAK4 Kinase Inhibitors: Emerging Biology and Therapeutic Implications

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

WEDNESDAY, MARCH 22

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Type I IFN Regulation of Bacterial Infection and Disease
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Alan Sher, NIAID, National Institutes of Health, USA

Thomas J. Scriba, University of Cape Town, South Africa
IFN Signatures that Predict Human Tuberculosis

Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
The Dichotomy between Interleukin 1 and Type I Interferon during Mycobacterium Tuberculosis Infection Exposes Distinct and Opposing Classes of Inflammation

Coffee Break

Craig R. Roy, Yale University School of Medicine, USA
Modulation of Type I Interferon Production during Infection by Vacuolar Pathogens

Jeffery S. Cox, University of California, Berkeley, USA
Discriminating Pathogen from Non-Pathogen: Beyond Type 1 IFN

Terje Espevik, Norwegian University of Science and Technology, Norway
Short Talk: CD150 Positively Regulates TRAM Recruitment to E.coli Phagosomes and Type I IFN Secretion

Beiyun Caitlin Liu, Tufts University, USA
Short Talk: Host-Intrinsic Interferon Signaling Licenses GBP-Mediated Attack on Cytosolic Bacteria

08:00—11:15
PRR Signaling in Bacterial and Viral Infection
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Russell E. Vance, University of California, Berkeley, USA
Activation of Inflammasomes by Bacterial Pathogens

Douglas Golenbock, University of Massachusetts Medical School, USA
Pattern Recognition in Bacterial Infections: Dual Roles for TLRs and Nucleic Acid Sensors

Coffee Break

Amal Amer, Ohio State University, USA
Unconventional Functions of Inflammasomes

Denise M. Monack, Stanford University, USA
Inflammasomes and Bacterial Infections

Christian Holm, Aarhus University, Denmark
Short Talk: Influenza A Virus Targets a cGAS-Independent STING Pathway that Controls Enveloped RNA Viruses

Peng Li, National Institute of Biological Sciences, China
Short Talk: Ubiquitination and Degradation of GBPs by Shigella Ipha9.8 Effector to Suppress Host Defenses

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Role of Type I IFN in Complex Autoimmunity
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Daniel Kastner, National Institutes of Health, USA

Virginia Pascual, Baylor Research Institute, USA
Pathogenic Functions of Type I IFN in SLE

Richard M. Siegel, NIAMS, National Institutes of Health, USA
Interferon, Anti-Interferon Antibodies and NK Cells in Systemic Autoimmunity

Robert C. Axtell, Oklahoma Medical Research Foundation, USA
Immunological Heterogeneity in Neurological Autoimmunity: Lessons from Studying Type I Interferon Responses

Mari L. Shinohara, Duke University, USA
Short Talk: Type-I Interferons and the NLRP3 Inflammasome in CNS Autoimmunity

17:00—19:00
Inflammasome and NF-kB Regulatory Mechanisms
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Christian Stehlik, Northwestern University, USA
Inflammasome Inhibition

Eicke Latz, University of Bonn, Germany
Inflammasomes in Health and Disease

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Reprogramming in Innate Immunity and Inflammation

Ali A. Zarrin, Genentech, Inc., USA
Short Talk: TPL2 Kinase Activates MEK-1/2 and/or MEK-3/6 to Regulate Inflammatory Pathways in Myeloid Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

THURSDAY, MARCH 23

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
Mechanisms Underlying Divergent Functions of Type I IFNs
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Anne O'Garra, Francis Crick Institute, UK

Jae U. Jung, Keck School of Medicine of University of Southern California, USA
TRIM-Mediated Control of Type I IFN Pathway

Marco Colonna, Washington University School of Medicine, USA
Targeting Type I IFN Activity through Plasmacytoid DC

Coffee Break

Laurel L. Lenz, University of Colorado, USA
Role of Type I - Type II IFN Crosstalk in Macrophage Effector Function

Gideon Schreiber, Weizmann Institute, Israel
The Molecular Basis for Differential Activity of Type I Interferons

Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Short Talk: Systems Biology of Type I Interferon Responses

Ronald L. Rabin, US Food and Drug Administration, USA
Short Talk: A Potential Modulatory Role for IFNalpha1 Dependent on its Low Affinity for IFNAR2

08:00—11:45
Interactions between Microbiota and the Innate Immune System
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Mihai G. Netea, Radboud University, Netherlands

Daniel Graham, Massachusetts General Hospital, USA
Host Genetics and Microbe Interactions in Human Disease

Kathy D. McCoy, University of Calgary, Canada
Intestinal Commensal Microbiota and Education of the Innate Immune System

Coffee Break

Gabriel Nuñez, University of Michigan, USA
Control of Pathogen Colonization by Host Immunity and the Microbiota in the Gut

Andrew T. Gewirtz, Georgia State University, USA
Microbial-Mediated Protection from Infectious Disease

Prosper N. Boyaka, Ohio State University, USA
Regulation of Mucosal Immunity by Toxins and Microbiota

Grace Yi Chen, University of Michigan, USA
Short Talk: NLRP6 Limits Colonization of Akkermansia to Protect Against the Development of Colitis and Colon Tumorigenesis

Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: Loss of Paneth Cell Autophagy Leads to Catastrophic Susceptibility to Acute Gastrointestinal Inflammation

11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 3: Role of Type I IFNS in Autoimmunity and Malignancy

Van Horne C
* Raphaela Theresia Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA

* Marco Colonna, Washington University School of Medicine, USA

Kebin Liu, Medical College of Georgia, USA
Jak-STAT-Mediated Chronic Inflammation Impairs Cytotoxic T Lymphocyte Activation to Decrease Anti-PD-1 Immunotherapy Efficacy in Pancreatic Cancer

Jacquelyn Gorman, Seattle Children's Research Institute, USA
The IFIH1A946T Coding Variant Mediates an Interferon Program that Limits Viral Infection but Increases the Risk for Autoimmunity

Mark E. Kleinman, University of Kentucky, USA
Epigenetic Regulation of Type I IFN Response in Age-Related Macular Degeneration

Elisaveta Voynova, Medimmune, USA
Blockade of Critical Immune Regulators Results in Different Roads to Pathogenesis in Primary Sjögren’s Syndrome

Mona Motwani, University of Massachusetts, USA
The cGAS-STING Pathway Restrains Systemic Autoimmunity

Simone Caielli, Baylor Institute for Immunology Research, USA
Oxidized Mitochondrial DNA is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype

Stephen Rubino, Brigham and Women's Hospital, USA
Activated Microglia Induce Type 1-interferon Dependent Neurodegeneration

14:30—16:00
Workshop 3: PRRs in Inflammatory Diseases

Van Horne A/B
* Amal Amer, Ohio State University, USA

* Dana Philpott, University of Toronto, Canada

Eric P. Hanson, National Institutes of Health, USA
A Novel NEMO Isoform Mediates Enhanced Antiviral Activity and Autoinflammatory Disease via Stabilization of IKKepsilon

Kiva V. Brennan, Trinity College Dublin, Ireland
Designing Vaccines for the Paediatric Population; Potential for Cytosolic Nucleic Acids as Vaccine Adjuvants

Nesrin Ozoren, Bogazici University, Turkey
ASC Specks as Vaccine Technology

Jingjin Ding, National Institute of Biological Sciences, China
LPS Binding to Caspase-11/4/5 Triggers Pyroptosis by Releasing the Pore-Forming Activity of GSDMD

Orna Rabinovich-Ernst, NIAID, National Institutes of Health, USA
An Arrayed Genome-Wide RNAi Screen for the Discovery of Novel Inflammasome Regulators

Thomas A. Kufer, University of Hohenheim, Germany
Roles of NLRP10 in Innate and Adaptive Immunity

16:00—16:30
Navigating the Peer Review Process
Information will be provided about how to understand the NIH peer review system with a focus on recent changes to the review process. Anyone interested in learning more about preparing an NIH grant application and tips about the review of grant applications is welcome to attend.

Van Horne A/B
* Tina M. McIntyre, National Institutes of Health, USA

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—18:45
Tailoring Type I IFN Interventions to Achieve Cure
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Alan Sher, NIAID, National Institutes of Health, USA

Geraldine P. Grouard-Vogel, Neovacs, France
Overexpression of IFNalpha and Derived Diseases: Innovative Approach with a Therapeutic Vaccine IFNalpha Kinoid

Miguel A. Sanjuan, Medimmune/Astrazeneca, USA
Novel Pathogenic Role for IgE in SLE, and Pharmacological Blockade of Type I IFN Receptor in Patients

John J. O'Shea, NIAMS, National Institutes of Health, USA
Targeting Type I IFN Signaling Pathways

17:00—18:45
Innate Immune Receptors and Metabolism
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
* Prosper N. Boyaka, Ohio State University, USA

Mohamed Lamkanfi, Ghent University, Belgium
Inflammasome Regulation in Auto-Inflammation

Vishwa Deep Dixit, Yale University, USA
Metabolic Control of Inflammasomes

Mihai G. Netea, Radboud University, Netherlands
Metabolic Basis for Trained Innate Immunity

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions
Registered attendees can view abstracts starting on 02/19/2017

Van Horne C
* Alan Sher, NIAID, National Institutes of Health, USA

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 02/19/2017

Van Horne A/B
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mezzanine 2

FRIDAY, MARCH 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

CEDARLANE

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI128981-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


MedImmune


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676