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This meeting took place in 2004
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Jaks and Stats: Development to Disease (E2)
Organizer(s) Robert D. Schreiber, David E. Levy and John J. O'Shea
April 15—20, 2004
Fairmont Chateau Whistler • Whistler, British Columbia Canada
Abstract Deadline: Dec 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 17, 2004
Sponsored in part by the Director's Sponsor Fund
Summary of Meeting:
The study of the Jak-Stat signaling pathway has now reached an extremely sophisticated level. Nevertheless, significant new insights continue to rapidly emerge involving either novel pathway components or novel actions of known pathway components that have profound influences on signaling through both the Jak-Stat pathway as well as other signaling pathways. Recent work has also shown that Jak and Stats are evolutionarily conserved signaling molecules that regulate a diverse group of fundamental processes ranging from stem cell renewal and embryogenesis to organogenesis and development of hematopoietic and lymphoid cells. Furthermore their roles in preventing or promoting infectious, malignant and autoimmune diseases have now become areas of intense study and exciting new findings are being made in these areas that have wide applicability to several fields of biology. The goals of this meeting are as follows: -Identify novel interactions between members of the Jak-Stat pathway not only with one another but also with receptors and components of other signal transduction pathways with special emphasis on positive and negative acting mechanisms that regulate Jak-Stat pathway signaling. -Define the roles of the Jak-Stat pathway and its components in development of primitive and higher organisms with special emphasis being placed on model genetic organisms and on the hematopoietic and immune systems. -Discuss the various protective versus disease-promoting effects of the Jak-Stat signaling pathway in infectious and neoplastic diseases.
View Scholarships/Awards
The study of the Jak-Stat signaling pathway has now reached an extremely sophisticated level. Nevertheless, significant new insights continue to rapidly emerge involving either novel pathway components or novel actions of known pathway components that have profound influences on signaling through both the Jak-Stat pathway as well as other signaling pathways. Recent work has also shown that Jak and Stats are evolutionarily conserved signaling molecules that regulate a diverse group of fundamental processes ranging from stem cell renewal and embryogenesis to organogenesis and development of hematopoietic and lymphoid cells. Furthermore their roles in preventing or promoting infectious, malignant and autoimmune diseases have now become areas of intense study and exciting new findings are being made in these areas that have wide applicability to several fields of biology. The goals of this meeting are as follows: -Identify novel interactions between members of the Jak-Stat pathway not only with one another but also with receptors and components of other signal transduction pathways with special emphasis on positive and negative acting mechanisms that regulate Jak-Stat pathway signaling. -Define the roles of the Jak-Stat pathway and its components in development of primitive and higher organisms with special emphasis being placed on model genetic organisms and on the hematopoietic and immune systems. -Discuss the various protective versus disease-promoting effects of the Jak-Stat signaling pathway in infectious and neoplastic diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, APRIL 15
FRIDAY, APRIL 16
SATURDAY, APRIL 17
SUNDAY, APRIL 18
MONDAY, APRIL 19
TUESDAY, APRIL 20
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, APRIL 15
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
James E. Darnell,
Rockefeller University, USA
Integrating STATs in Transcriptional and Developmental Function
Integrating STATs in Transcriptional and Developmental Function
08:00—11:00
Jaks and Receptors
Meeting has ended...abstracts no longer viewable online.
John J. O'Shea,
NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation
*
Sandra Pellegrini,
Institut Pasteur, France
Jaks and Cytokine Receptor Traffic
Jaks and Cytokine Receptor Traffic
Peter C. Heinrich,
Universitätsklinikum Aachen, Germany
IL-6-type Cytokine Receptor-JAK-STAT-Interactions and Modulation of Signaling
IL-6-type Cytokine Receptor-JAK-STAT-Interactions and Modulation of Signaling
Christin Carter-Su,
University of Michigan Medical School, USA
Short Talk: Sites of JAK2 Autophosphorylation and Their Function in Cytokine Signaling
Short Talk: Sites of JAK2 Autophosphorylation and Their Function in Cytokine Signaling
Paul J. Hertzog,
Hudson Institute of Medical Research, Australia
Short Talk: SOCI Regulation of Signalling through the Type IIFN Receptor
Short Talk: SOCI Regulation of Signalling through the Type IIFN Receptor
17:00—19:00
Stats: Structure and Function
Meeting has ended...abstracts no longer viewable online.
George R. Stark,
Case Western Reserve University, USA
Role of Unphosphorylated STAT3 in Cancer and in Response to Cytokines
Role of Unphosphorylated STAT3 in Cancer and in Response to Cytokines
Friedemann Horn,
Universitat Leipzig, Germany
Short Talk: Stat3 Serine Phosphorylation Reevaluated
Short Talk: Stat3 Serine Phosphorylation Reevaluated
08:00—11:00
Negative Regulation
Meeting has ended...abstracts no longer viewable online.
*
Douglas J. Hilton,
Walter and Eliza Hall Institute of Medical Research, Australia
SOCS Proteins Regulate the Quantity and Quality of Jak/Stat Signaling
SOCS Proteins Regulate the Quantity and Quality of Jak/Stat Signaling
Akihiko Yoshimura,
Keio University, Japan
SOCS1 and SOCS3; Key Positive and Negative Regulators for Macrophage and Dendritic Cell Activation
SOCS1 and SOCS3; Key Positive and Negative Regulators for Macrophage and Dendritic Cell Activation
Ke Shuai,
University of California, Los Angeles, USA
Negative Regulation of Cytokine Signaling in the Nucleus
Negative Regulation of Cytokine Signaling in the Nucleus
Benjamin G. Neel,
Ontario Cancer Institute, Canada
Role of Shp2 in Normal and Abnormal Hematopoiesis
Role of Shp2 in Normal and Abnormal Hematopoiesis
Michelle Ann Soriano,
Harvard School of Public Health, USA
Short Talk: Isolation and Characterization of a Novel Negative Regulator of STAT4 Signaling
Short Talk: Isolation and Characterization of a Novel Negative Regulator of STAT4 Signaling
14:00—16:00
Workshop 1: IRFs and Other Transcription Factors
*
Keiko Ozato,
NICHD, National Institutes of Health, USA
IRFs as Downstream Effectors of Stat-Dependent Biologic Responses
IRFs as Downstream Effectors of Stat-Dependent Biologic Responses
Isabelle J. Marie,
New York University School of Medicine, USA
Activation of IRF7 during Pathogen Infection: Kinases, Phosphorylation Sites and Regulatory Mechanisms
Activation of IRF7 during Pathogen Infection: Kinases, Phosphorylation Sites and Regulatory Mechanisms
Niamh E. Buckley,
Queen's University, Northern Ireland
IRF-7 Plays a Key Role in the BRCA 1/Interferon Gamma Mediated Apoptotic Response
IRF-7 Plays a Key Role in the BRCA 1/Interferon Gamma Mediated Apoptotic Response
Oanh Dang,
University of California, San Diego, USA
Anthrax Lethal Toxin Inhibits Activation of Interferon Regulatory Factor 3 by LPS
Anthrax Lethal Toxin Inhibits Activation of Interferon Regulatory Factor 3 by LPS
Mirjam J. Eckert,
University of Lausanne, Switzerland
The Extreme C-Terminus of IRF-1 has an effect on its Transcriptional Activity
The Extreme C-Terminus of IRF-1 has an effect on its Transcriptional Activity
Lisa N. Haubein,
University of Pennsylvania, USA
Regulation of Stat5 Function by c-Myb
Regulation of Stat5 Function by c-Myb
17:00—19:00
Jak-Stat Pathway in Non-Mammalian Development
Meeting has ended...abstracts no longer viewable online.
Jeffrey G. Williams,
University of Dundee, School of Biological Sciences, UK
Functional Analysis of the Four Dictyostelium STAT Proteins and a Crystal Structure for Activated Dd-STATa in its DNA-Unbound Form
Functional Analysis of the Four Dictyostelium STAT Proteins and a Crystal Structure for Activated Dd-STATa in its DNA-Unbound Form
Toshio Hirano,
Osaka University Graduate School of Medicine, Japan
Jaks and Stats in Epithelial-Mesenchymal Transition of Zebrafish Gastrula Organizer
Jaks and Stats in Epithelial-Mesenchymal Transition of Zebrafish Gastrula Organizer
Erika A. Bach,
New York University School of Medicine, USA
Short Talk: Epidermal Growth Factor Receptor (Egfr) Signaling in the Drosophila Embryo Requires a Functional JAK/STAT Pathway
Short Talk: Epidermal Growth Factor Receptor (Egfr) Signaling in the Drosophila Embryo Requires a Functional JAK/STAT Pathway
08:00—11:00
Jak-Stat Pathway in Mammalian Development
Meeting has ended...abstracts no longer viewable online.
James N. Ihle,
St. Jude Children's Research Hospital, USA
Stat5 Function Revisited
Stat5 Function Revisited
*
Lothar Hennighausen,
National Institutes of Health, USA
Cell-Specific and Temporal Inactivation of the Stat5 Locus in the Mouse
Cell-Specific and Temporal Inactivation of the Stat5 Locus in the Mouse
Christine J. Watson,
University of Cambridge, UK
Short Talk: The Multiple Roles of Stat Factors, and their Downstream Effectors, in Regulating Differentiation, Apoptosis and Remodeling in Mammary Gland
Short Talk: The Multiple Roles of Stat Factors, and their Downstream Effectors, in Regulating Differentiation, Apoptosis and Remodeling in Mammary Gland
Michael A. Farrar,
University of Minnesota, USA
Short Talk: Differential Regulation of B and T Cell Development by STAT5
Short Talk: Differential Regulation of B and T Cell Development by STAT5
Valeria Poli,
University of Turin, Italy
Short Talk: Non-Redundant Functions of STAT3alpha and STAT3beta revealed by Specific Ablation of Either Isoform
Short Talk: Non-Redundant Functions of STAT3alpha and STAT3beta revealed by Specific Ablation of Either Isoform
14:00—16:00
Workshop 2: New Cytokines, Cytokine Receptors and Signaling Regulators
*
Paul B. Rothman,
University of Iowa, USA
Alexander S. Banks,
Harvard Medical School, USA
Suppressor of Cytokine Signaling-7 Deficiency Results in Decreased Body Size, Increased Growth of Pancreatic Islets, and Altered Glucose Homeostasis
Suppressor of Cytokine Signaling-7 Deficiency Results in Decreased Body Size, Increased Growth of Pancreatic Islets, and Altered Glucose Homeostasis
Christine Brender,
St. Vincent's Institute of Medical Research, Australia
Regulation of T Cell Homeostasis by SOCS1 and SOCS3
Regulation of T Cell Homeostasis by SOCS1 and SOCS3
Andrei Thomas-Tikhonenko,
Children's Hospital of Philadelphia and University of Pennsylvania, USA
An Essential Role of Th1 Responses and Interferon gamma/STAT1 Signaling in Infection-Mediated Anti-Angiogenesis and Suppression of Neoplastic Growth
An Essential Role of Th1 Responses and Interferon gamma/STAT1 Signaling in Infection-Mediated Anti-Angiogenesis and Suppression of Neoplastic Growth
Ana P. Costa-Pereira,
Cancer Research UK, UK
Novel Signaling Requirements for the Class II HLA and Antiviral Responses to Interferon-gamma
Novel Signaling Requirements for the Class II HLA and Antiviral Responses to Interferon-gamma
Alejandro Villarino,
NIAMS, National Institutes of Health, USA
The IL-27R (WSX-1) is Required to Suppress Effector T Cell Functions during Infection
The IL-27R (WSX-1) is Required to Suppress Effector T Cell Functions during Infection
Pravin B. Sehgal,
New York Medical College, USA
Disruption of Endothelial-Cell Caveolin-1/Raft Scaffolding and STAT3 Activation in the Lung during Development of Monocrotaline-Induced Pulmonary Hypertension
Disruption of Endothelial-Cell Caveolin-1/Raft Scaffolding and STAT3 Activation in the Lung during Development of Monocrotaline-Induced Pulmonary Hypertension
17:00—19:00
Jak-Stat Pathway in Immune Regulation
Meeting has ended...abstracts no longer viewable online.
*
Kenneth M. Murphy,
HHMI/Washington University School of Medicine, USA
Stats in T Helper Cell Development
Stats in T Helper Cell Development
Xiaomin Chen,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Structural and Biochemical Studies of STAT Proteins
Short Talk: Structural and Biochemical Studies of STAT Proteins
Olli J. Silvennoinen,
University of Tampere, Finland
Short Talk: Regulation of Jaks and Stats in Cytokine Receptor Signaling
Short Talk: Regulation of Jaks and Stats in Cytokine Receptor Signaling
Azad Bonni,
Harvard Medical School, USA
Short Talk: Deregulation of the LIFRbeta-STAT3 Signaling Pathway In Brain Tumors
Short Talk: Deregulation of the LIFRbeta-STAT3 Signaling Pathway In Brain Tumors
Mariusz A. Wasik,
University of Pennsylvania, USA
Short Talk: Stat3-Mediated Epigenetic Silencing of SHP-1 Phosphatase Expression in Malignant T-Cell
Short Talk: Stat3-Mediated Epigenetic Silencing of SHP-1 Phosphatase Expression in Malignant T-Cell
08:00—11:00
Jak-Stat Pathway in Cancer
Meeting has ended...abstracts no longer viewable online.
Robert D. Schreiber,
Washington University School of Medicine, USA
Stat 1 and Cancer Immunoediting
Stat 1 and Cancer Immunoediting
David E. Levy,
New York University School of Medicine, USA
Multiple Distinct Mechanisms Underline the Role of Stat3 in Malignant Transformation
Multiple Distinct Mechanisms Underline the Role of Stat3 in Malignant Transformation
*
Jacqueline F. Bromberg,
Memorial Sloan Kettering Cancer Center, USA
Stats and Tumorigenesis in Epithelial Cells - Breast and Prostate Cancer
Stats and Tumorigenesis in Epithelial Cells - Breast and Prostate Cancer
Richard Jove,
Vaccine & Gene Therapy Institute of Florida, USA
Stats as Novel Targets for Cancer Therapy
Stats as Novel Targets for Cancer Therapy
Jennifer Rubin Grandis,
University of Pittsburgh Eye & Ear Institute, USA
Short Talk: STAT Alterations in Head and Neck Cancer
Short Talk: STAT Alterations in Head and Neck Cancer
17:00—19:00
Jak-Stat Pathway in Infectious Disease
Meeting has ended...abstracts no longer viewable online.
Jean-Laurent Casanova,
Rockefeller University, USA
Inherited Disorders of Human Stat-1 and Infectious Diseases
Inherited Disorders of Human Stat-1 and Infectious Diseases
*
Thomas A.F. Decker,
Vienna Biocenter, University of Vienna, Austria
Interferons and Stats in Machrophage Responses to Intracellular Bacteria
Interferons and Stats in Machrophage Responses to Intracellular Bacteria
Christine A. Biron,
Brown University, USA
STATs in Immune Responses to Viral Infections - Type 1 IFNs
STATs in Immune Responses to Viral Infections - Type 1 IFNs
Curt M. Horvath,
Northwestern University, USA
Short Talk: Viral Coalitions Uncover Weapons of STAT Destruction
Short Talk: Viral Coalitions Uncover Weapons of STAT Destruction
*Session Chair †Invited, not yet responded.
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