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This meeting took place in 2004
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Natural Variation and Quantitative Genetics in Model Organisms (J2)
Organizer(s) Detlef Weigel and Bruce Walsh
January 8—13, 2004
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Oct 15, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 10, 2003
Supported by Keystone Symposia
Summary of Meeting:
Despite tremendous advances in the genetic analysis of many biological processes, the molecular basis of the variation seen within and between species remains largely unknown. ·Standard genetic analyses in model organisms have focused on laboratory-induced mutations with large phenotypic effects, which contrasts with the variation seen in natural populations, which is mostly continuous. The phenotypic variation seen within or between closely related species also contrasts with the phenotypic variation seen between more distantly related species. It seems likely, however, that intra- and interspecific variation are two sides of the same coin, although a unifying molecular framework has not yet been developed. Now is an exciting time to revisit these questions because of several major technological advances. These include new analytical tools, such as high-throughput genotyping, new statistical and computational methods, comprehensive transcriptome and proteome profiling, as well as opportunities to compare entire genomes between closely and distantly related organisms. Understanding the molecular basis of natural variation has important implications both for understanding the evolution of new traits, as well as for understanding how selection has shaped genomes, including the human genome. The meeting will have as a major focus both animal and plant model organisms, in which the use of quantitative genetics is experiencing a renaissance. The molecular study of Quantitative Trait Loci, several of which have been traced back to individual genes, is allowing important conclusions as to the type of genes and type of changes that underlie quantitative phenotypic variation. A second focus of the meeting will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. The overall goal of this meeting is to bring together a diverse group of investigators that includes scientists interested in the evolution of developmental diversity, quantitative geneticists and population geneticists. ·Finally, the proposed meeting, which will focus on genetic model organisms such as Drosophila and Arabidopsis, will be an excellent complement to the meeting that is to be held concurrently, on Human Genetic Diversity.
View Scholarships/Awards
Despite tremendous advances in the genetic analysis of many biological processes, the molecular basis of the variation seen within and between species remains largely unknown. ·Standard genetic analyses in model organisms have focused on laboratory-induced mutations with large phenotypic effects, which contrasts with the variation seen in natural populations, which is mostly continuous. The phenotypic variation seen within or between closely related species also contrasts with the phenotypic variation seen between more distantly related species. It seems likely, however, that intra- and interspecific variation are two sides of the same coin, although a unifying molecular framework has not yet been developed. Now is an exciting time to revisit these questions because of several major technological advances. These include new analytical tools, such as high-throughput genotyping, new statistical and computational methods, comprehensive transcriptome and proteome profiling, as well as opportunities to compare entire genomes between closely and distantly related organisms. Understanding the molecular basis of natural variation has important implications both for understanding the evolution of new traits, as well as for understanding how selection has shaped genomes, including the human genome. The meeting will have as a major focus both animal and plant model organisms, in which the use of quantitative genetics is experiencing a renaissance. The molecular study of Quantitative Trait Loci, several of which have been traced back to individual genes, is allowing important conclusions as to the type of genes and type of changes that underlie quantitative phenotypic variation. A second focus of the meeting will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. The overall goal of this meeting is to bring together a diverse group of investigators that includes scientists interested in the evolution of developmental diversity, quantitative geneticists and population geneticists. ·Finally, the proposed meeting, which will focus on genetic model organisms such as Drosophila and Arabidopsis, will be an excellent complement to the meeting that is to be held concurrently, on Human Genetic Diversity.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, JANUARY 8
FRIDAY, JANUARY 9
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
SATURDAY, JANUARY 10
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
SUNDAY, JANUARY 11
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
MONDAY, JANUARY 12
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
TUESDAY, JANUARY 13
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, JANUARY 8
19:30—21:30
Keynote Session: Genetic Dissection of Complex Traits (Joint)
Meeting has ended...abstracts no longer viewable online.
*
David M. Altshuler,
Vertex Pharmaceuticals Incorporated, USA
Charles H. Langley,
University of California, Davis, USA
Polymorphism and Divergence Across the Drosophila Genome
Polymorphism and Divergence Across the Drosophila Genome
Aravinda Chakravarti,
Johns Hopkins University School of Medicine, USA
The Nature of Variation in Complex Disease
The Nature of Variation in Complex Disease
08:00—11:00
QTL in Animals I
Meeting has ended...abstracts no longer viewable online.
*
Trudy F.C. Mackay,
North Carolina State University, USA
Catherine (Katie) L. Peichel,
Fred Hutchinson Cancer Research Center, USA
Genetic Analysis of Reproductive Isolation in Sticklebacks
Genetic Analysis of Reproductive Isolation in Sticklebacks
Peter D. Keightley,
University of Edinburgh, UK
Analysing Quantitative Genetic Variation for Growth in Mice
Analysing Quantitative Genetic Variation for Growth in Mice
Kari J. Buck,
Oregon Health & Science University, USA
Genetic Control of Physical Dependence and Associated Withdrawal Episodes in Mice
Genetic Control of Physical Dependence and Associated Withdrawal Episodes in Mice
Thomas E. Johnson,
University of Colorado, USA
QTLs in Mice and Worms; Use of Recombinant Inbred Strains
QTLs in Mice and Worms; Use of Recombinant Inbred Strains
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
08:00—11:00
Patterns of Human Genome Sequence Variation
Meeting has ended...abstracts no longer viewable online.
*
Peter Donnelly,
University of Oxford, UK
Mark Daly,
Massachusetts General Hospital, USA
Human Haplotype Structure
Human Haplotype Structure
Lon Cardon,
University of Oxford, UK
Haplotype Structure Across Chromosomes
Haplotype Structure Across Chromosomes
Kelly A. Frazer,
University of California, San Diego, USA
Genetic Variation and Human Disease
Genetic Variation and Human Disease
Andrew G. Clark,
Cornell University, USA
Lessons from Candidate Gene Studies about the Genetics of Complex Traits
Lessons from Candidate Gene Studies about the Genetics of Complex Traits
17:00—19:00
Exploiting Inbred Strains to Understand Complex Traits (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Peter D. Keightley,
University of Edinburgh, UK
Keith R. Davis,
Icoria, Inc, USA
High-Throughput Plant Gene Function Analysis in Arabidopsis
High-Throughput Plant Gene Function Analysis in Arabidopsis
Wayne Frankel,
The Jackson Laboratory, USA
Effects of Genetic Background on Induced and Spontaneous, Monogenic and Polygenic Models for Epilepsy in Mice
Effects of Genetic Background on Induced and Spontaneous, Monogenic and Polygenic Models for Epilepsy in Mice
Michael P. Snyder,
Stanford University School of Medicine, USA
Identification of Functional Regions in the Genomes of Yeast and Humans
Identification of Functional Regions in the Genomes of Yeast and Humans
18:45—19:20
Comparative Genomics
Meeting has ended...abstracts no longer viewable online.
Eric S. Lander,
Massachusetts Institute of Technology, USA
08:00—11:00
QTL in Animals II
Meeting has ended...abstracts no longer viewable online.
*
Catherine (Katie) L. Peichel,
Fred Hutchinson Cancer Research Center, USA
Trudy F.C. Mackay,
North Carolina State University, USA
Molecular Quantitative Genetics of Drosophila Life Span
Molecular Quantitative Genetics of Drosophila Life Span
Chung-I Wu,
Chinese Academy of Sciences, China
Molecular Genetics of Speciation
Molecular Genetics of Speciation
John H. Werren,
University of Rochester, USA
Evolutionary Genetics of Species Differences in Nasonia
Evolutionary Genetics of Species Differences in Nasonia
Marta L. Wayne,
University of Florida, USA
Sex Dimorphism and Non-Additivity in Gene Expression in Drosophila melanogaster
Sex Dimorphism and Non-Additivity in Gene Expression in Drosophila melanogaster
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
08:00—11:00
Molecular Forces Shaping Genome Sequence Variation
Meeting has ended...abstracts no longer viewable online.
Peter Donnelly,
University of Oxford, UK
Understanding Fine-Scale Variation in Recombination Rates
Understanding Fine-Scale Variation in Recombination Rates
Richard Hudson,
University of Chicago, USA
Fine-Scale Mapping with Linkage Disequilibrium
Fine-Scale Mapping with Linkage Disequilibrium
Chris Toomajian,
University of Southern California, USA
The Pattern of Polymorphism in the Arabidopsis Genome
The Pattern of Polymorphism in the Arabidopsis Genome
Evan E. Eichler,
HHMI/University of Washington, USA
Structural Variation and Large-Scale Polymorphism within Segmental Duplications
Structural Variation and Large-Scale Polymorphism within Segmental Duplications
Richard M. Durbin,
Wellcome Trust Sanger Institute, UK
Short Talk: Significant Correspondence of Recombination Events in Pedigrees with Haplotype Block Boundaries
Short Talk: Significant Correspondence of Recombination Events in Pedigrees with Haplotype Block Boundaries
17:00—19:00
QTL in Plants I
Meeting has ended...abstracts no longer viewable online.
*
Joanne Chory,
The Salk Institute, USA
Masahiro Yano,
National Institute of Agrobiological Resources, Japan
Natural Variation in Flowering Time in Rice
Natural Variation in Flowering Time in Rice
Leonie C. Moyle,
University of California, Davis, USA
Salad Speciation: Genetics of Species Differences and Hybrid Incompatibility in Lycopersicon
Salad Speciation: Genetics of Species Differences and Hybrid Incompatibility in Lycopersicon
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
17:00—19:00
Population History and Human Sequence Variation
Meeting has ended...abstracts no longer viewable online.
*
Stephen J. O'Brien,
National Cancer Institute, National Institutes of Health, USA
John Raelson,
Galileo Genomics, Canada
Short Talk: General Extent of LD in the Quebec Founder Population
Short Talk: General Extent of LD in the Quebec Founder Population
Mark Patterson,
Public Library of Science, UK
Short Talk: Public Library of Science
Short Talk: Public Library of Science
08:00—11:00
Inherited Variation in Gene Expression (Joint)
Meeting has ended...abstracts no longer viewable online.
Stephanie Monks,
University of Washington, USA
The Genetics of Gene Expression in Mice
The Genetics of Gene Expression in Mice
Justin Fay,
Washington University, USA
Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence
Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence
Matthew Rockman,
New York University, USA
Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease
Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease
17:00—19:00
QTL in Plants II
Meeting has ended...abstracts no longer viewable online.
*
Masahiro Yano,
National Institute of Agrobiological Resources, Japan
Joanne Chory,
The Salk Institute, USA
and
and
Olivier Loudet,
Institut National de La Recherche Agronomique, France
Natural Variation in Light Signaling in Arabidopsis
Natural Variation in Light Signaling in Arabidopsis
Carlos Alonso-Blanco,
Centro Nacional de Biotecnologia, CSIC, Spain
Natural Variation for Life History Traits in Arabidopsis
Natural Variation for Life History Traits in Arabidopsis
Dani Zamir,
Cornell University, USA
Real Time QTL of Tomato Yield
Real Time QTL of Tomato Yield
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
17:00—19:00
Genetic Architecture of Human Disease
Meeting has ended...abstracts no longer viewable online.
*
Lon Cardon,
University of Oxford, UK
Stephen J. O'Brien,
National Cancer Institute, National Institutes of Health, USA
Architecture of Disease: Lessons from HIV Resistance
Architecture of Disease: Lessons from HIV Resistance
John A. Phillips,
Vanderbilt University School of Medicine, USA
Short Talk: PPH is a Complex Disease Caused by Rare and Common Variants
Short Talk: PPH is a Complex Disease Caused by Rare and Common Variants
Hua Tang,
University of Chicago, USA
Short Talk: Genetic Diseases and Natural Selection in Human
Short Talk: Genetic Diseases and Natural Selection in Human
Örjan Carlborg,
Roslin Institute, Scotland
Short Talk: The Use of Epistasis in Genetic Dissection of Complex Traits
Short Talk: The Use of Epistasis in Genetic Dissection of Complex Traits
08:00—11:00
Evolution of Adaptive Traits
Meeting has ended...abstracts no longer viewable online.
*
Neelima Sinha,
University of California, Davis, USA
June B. Nasrallah,
Cornell University, USA
Diversification of Self-Incompatibility Genes in the Brassicaceae
Diversification of Self-Incompatibility Genes in the Brassicaceae
Thomas Mitchell-Olds,
Duke University, USA
Nucleotide Polymorphism and Quantitative Trait Variation in Arabidopsis and Related Species
Nucleotide Polymorphism and Quantitative Trait Variation in Arabidopsis and Related Species
Sean B. Carroll,
University of Wisconsin-Madison, USA
Genetic and Developmental Mechanisms Underlying Divergent and Convergent Patterns of Evolution
Genetic and Developmental Mechanisms Underlying Divergent and Convergent Patterns of Evolution
Ying Tan,
University of Massachusetts-Boston, USA
Molecular Evolution of Color Vision Genes in Primates
Molecular Evolution of Color Vision Genes in Primates
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
08:00—11:00
Genetic Determinants of Common Disease
Meeting has ended...abstracts no longer viewable online.
*
Francis S. Collins,
Director, National Institutes of Health, USA
Richard P. Lifton,
HHMI/Yale University School of Medicine, USA
Genetic Dissection of Hypertension
Genetic Dissection of Hypertension
Gilles Thomas,
NCI - National Institutes of Health, USA
The Genetics of CARD15, a Susceptibility Gene for an Inflammatory Bowel Disease
The Genetics of CARD15, a Susceptibility Gene for an Inflammatory Bowel Disease
David M. Altshuler,
Vertex Pharmaceuticals Incorporated, USA
Genetic Analysis of Diabetes
Genetic Analysis of Diabetes
David Hunter,
Harvard Medical School, USA
Gene-Environment Interactions
Gene-Environment Interactions
17:00—19:00
Variation between Distant Taxa
Meeting has ended...abstracts no longer viewable online.
*
Ying Tan,
University of Massachusetts-Boston, USA
Nipam H. Patel,
University of California, Berkeley, USA
The Evolution of Arthropod Pattern Formation
The Evolution of Arthropod Pattern Formation
Neelima Sinha,
University of California, Davis, USA
The Development and Evolution of Leaves
The Development and Evolution of Leaves
Marie-Anne Felix,
Institut Jacques Monod, France
Evolution of Nematode Vulva Development: A Microevolutionary Approach
Evolution of Nematode Vulva Development: A Microevolutionary Approach
Following Session is for Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
17:00—19:00
Application to Biology, Medicine and Society
Meeting has ended...abstracts no longer viewable online.
*
Richard P. Lifton,
HHMI/Yale University School of Medicine, USA
Georgia Dunston,
Howard University, USA
The GRAD Biobank: A Resource for Exploring Genome Variation and Environment Interaction in Common Complex Diseases
The GRAD Biobank: A Resource for Exploring Genome Variation and Environment Interaction in Common Complex Diseases
Klaus Lindpaintner,
F. Hoffmann-La Roche AG, Switzerland
Pharmacogenetics: A Realistic View
Pharmacogenetics: A Realistic View
Francis S. Collins,
Director, National Institutes of Health, USA
Applying Genetics to Medicine and Society
Applying Genetics to Medicine and Society
*Session Chair †Invited, not yet responded.
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