Granlibakken Tahoe Floorplan

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This meeting took place in 2019



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Cell Competition in Development and Disease (B6)


Organizer(s) Margaret A. Goodell, Laura A. Johnston and Thomas P. Zwaka
February 24—28, 2019
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 24, 2018
Abstract Deadline: Dec 7, 2018
Scholarship Deadline: Oct 24, 2018
Discounted Registration Deadline: Jan 8, 2019

Supported by the Directors' Fund

Summary of Meeting:
Cell competition represents a radical departure from the established view that embryonic development is simply a matter of following a preprogrammed set of rules. Instead, it is a highly conserved process that promotes the context dependent elimination of less fit cells and stimulates growth of more fit cells during growth and homeostasis. Although it has long been known that the basis of competition is the ability of growing cells to monitor fitness of their neighbors, and can be induced via differences in protein production capacity, Myc levels and apico-basal cell polarity, only recently have signaling and effector mechanisms been identified. This conference aims to bring together, for the first time, researchers, from diverse fields, who study competitive and cooperative interactions between cells. It will cover recent findings on quality control systems, developing tissues, stem cell populations, and tumorigenesis, as well as address important evolutionary aspects of competitive and cooperative behavior in diverse model systems. New technologies have uncovered the prevalence of cell competition in humans, with surprising outcomes and implications for human disease. As the first broad meeting of this sort, we expect to define critical questions shared by the diverse investigators and shape this emerging area. Given the wide range of developmental and homeostatic systems that are controlled by cell competition, understanding the mechanisms and consequences of competitive interactions may permit the manipulation of these processes for therapeutic purposes.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a keynote address and closing plenary session from 17:00 to 19:15, followed by dinner and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.

SUNDAY, FEBRUARY 24

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

Granhall
08:00—11:15
Cell Competition in Development
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Cassandra G. Extavour, Harvard University, USA

Laura A. Johnston, Columbia University, USA
Sensing and Responding to Differences in Cell Fitness During Tissue Growth

Magdalena D. Zernicka-Goetz, University of Cambridge, UK
Cell Selection in Mammalian Embryos

Coffee Break

Hiromitsu Nakauchi, Stanford University, USA
Cell Competition in Interspecies Chimeras

Nicholas E. Baker, Albert Einstein College of Medicine, USA
Ribosomal Control of Cell Competition

Stephanie Ellis, Rockefeller University, USA
Short Talk: Distinct Modes of Cell Competition Shape Tissue Morphogenesis and Function in Mammalian Skin

Munemasa (Mooney) Mori, Columbia University Medical Center, USA
Short Talk: Cell Specification or Proliferation? Which Will Win for an Organ Generation?

Yoichiro Tamori, Hokkaido University, Japan
Short Talk: Mechanical Compensation in Postmitotic Cell Competition

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—17:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Gad Shaulsky, Baylor College of Medicine, USA

Kevin Foster, University of Oxford, UK
Evolution of Competition and Cooperation in Microbes

17:45—19:00
Evolution of Competition and Cooperation
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA

Gad Shaulsky, Baylor College of Medicine, USA
Cooperation and Competition in Dictyostelium

Anthony De Tomaso, University of California, Santa Barbara, USA
Inter-Individual Competition in the Colonial Ascidian, Botryllus schlosseri

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

Granhall
08:00—11:15
Stem Cell Competition
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA

Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Cell Competition during Early Embryogenesis Resembles Primitive Immune System

Margaret A. Goodell, Baylor College of Medicine, USA
Mutations Improving Fitness of Hematopoietic Stem Cells

Coffee Break

Cassandra G. Extavour, Harvard University, USA
Cell Competition in the Germ Line: Evidence, Theoretical Implications and Future Directions

Valentina Greco, Yale School of Medicine, USA
Principles of Tissue Dynamics and Function Captured by Live Imaging

Todd G. Nystul, University of California, San Francisco, USA
Short Talk: Competition for an Epithelial Stem Cell Niche Is Associated with Increased Proliferation, Differentiation Defects and Expanded Niche Signaling

Kimberly T. Truong, University of Utah, USA
Short Talk: Combining Stochastic Models and CRISPR Barcoding to Reveal Stem Cell Dynamics

Irène Aksoy, Stem Cell and Brain Research Institute, France
Short Talk: An Assessment of the Capacity of Mouse Embryonic Stem Cells and Rhesus Monkey Naive-Like Pluripotent Stem Cells to Colonize Pre-Implantation Embryos and Produce Inter-Species Chimeras in Rabbits

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop: Cell Competition Models

Mountain/Lake
* Valentina Greco, Yale School of Medicine, USA

Timothy J. Aikin, Johns Hopkins School of Medicine, USA
Dynamics-Dependent Horizontal ERK Signaling Coordinates Extrusion of Single Oncogenic Cells

Xiaotian Zhang, Van Andel Institute, USA
Systematic Inflammation Promotes the Hematopoietic Disease Development in TET2 Mutant Background

Huichun Zhan, Stony Brook Medicine, USA
Competition between Wild-Type and Mutant Hematopoietic Stem Cells Prevents Mutant Clone Expansion in a Murine Model of JAK2V617F-Positive Myeloproliferative Neoplasm

Kazutaka Akagi, National Center for Geriatrics and Gerontology, Japan
Dietary Restriction Improves Intestinal Cellular Fitness to Enhance Gut Barrier Function and Lifespan in D. melanogaster

Min Kyu Yum, Cambridge University, UK
Tumor-Initiating Clone Remodels the Niche Size and Environment of Neighboring Normal Clones

Andrew RJ Lawson, Wellcome Sanger Institute, UK
Somatic Evolution in Healthy and Diseased Bladder Urothelium

Jun Wu, University of Texas Southwestern Medical Center, USA
Cell Competition Constitutes a Barrier for Efficient Interspecies Chimerism between Evolutionary Distant Species

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
The Germline
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Tamily Weissman, Lewis and Clark College, USA

Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA
Pluripotency beyond Embryogenesis: Cell Competition and Fate Determination

Diana J. Laird, University of California, San Francisco, USA
Clonal Behaviors and Heterogeneity of Primordial Germ Cells

Erika Matunis, Johns Hopkins University School of Medicine, USA
Competing for the Niche in the Drosophila Testis

Erika A. Bach, New York University School of Medicine, USA
Short Talk: Chinmo-Mutant Germline Stem Cells Cause Mitotic Drive by Fencing Off the Niche and Evicting their Neighbors

Alexey Ryazanov, Robert Wood Johnson Medical School, USA
Short Talk: Unraveling the Mystery of Elongation Factor 2 Kinase: The Key Mechanism to Facilitate Cell Competition

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Granhall
08:00—11:30
Mosaicism and Selection in Normal Tissues
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Margaret A. Goodell, Baylor College of Medicine, USA

Kristin Baldwin, The Scripps Research Institute, USA
Mosaicism in the Brain - Genomic and Interspecies Studies

Inigo Martincorena, Wellcome Trust Sanger Institute, UK
The Hidden World of Somatic Evolution

Tamily Weissman, Lewis and Clark College, USA
Short Talk: Coordinated Clonal Cell Dynamics in the Developing Brain

Coffee Break

Philip H. Jones, Wellcome Trust Sanger Institute / University of Cambridge, UK
Outcompeting p53 Mutant Clones in Normal Esophagus through Redox Manipulation

Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

Rong Lu, University of Southern California, USA
Short Talk: Competition between Individual Hematopoietic Stem Cells during Bone Marrow Transplantation

Eric Martin Pietras, University of Colorado Anschutz Medical Campus, USA
Short Talk: Chronic Interleukin-1 Reduces HSC Fitness via PU.1-Dependent Growth Arrest

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Cell Selection in Human Disease I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* James DeGregori, University of Colorado Denver School of Medicine, USA

Thierry Voet, KU Leuven, Belgium
Genome Instability and Fitness in the Developing Human Embryo

David FitzPatrick, University of Edinburgh, UK
Post-Zygotic, Mosaic, Monoallelic Null Mutations in NIPBL Effect a Complete Phenocopy of Constitutional NIPBL Haploinsufficiency: Winning through Loss?

Mariaceleste Aragona, Université Libre De Bruxelles, Belgium
Short Talk: Stem Cell Dynamic and Signaling Controlling Mechanical Force-Mediated Skin Expansion

Sanne van Neerven, University of Amsterdam, Netherlands
Short Talk: Intestinal Stem Cell Competition in Lynch Syndrome

Rocio Vicario, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Microglia Mosaicism in Neurodegenerative Diseases

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 3

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

THURSDAY, FEBRUARY 28

07:00—08:00
Breakfast

Granhall
08:00—08:30
Cell Selection in Human Disease II
Meeting has ended...abstracts no longer viewable online.

* James DeGregori, University of Colorado Denver School of Medicine, USA

Matthew Hurles, Wellcome Trust Sanger Institute, UK
Mosacism and Implications for Human Developmental Disorders

08:30—11:15
Aging and Pre-Malignancy
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Stephanie Ellis, Rockefeller University, USA

James DeGregori, University of Colorado Denver School of Medicine, USA
The Ecology of Cancer: How Changes in Tissue Microenvironments Drive Cancer Evolution as we Age

Coffee Break

Coleman Lindsley, Dana-Farber Cancer Institute, USA
Clonal Hematopoiesis as Stem Cell Competition

Tatsushi Igaki, Kyoto University Graduate School of Biostudies, Japan
Mechanism of Tumor-Suppressive Cell Competition

Richard White, Memorial Sloan Kettering Cancer Center, USA
Short Talk: The Zebrafish as a Model for Cooperative/Competitive Interactions between Tumor and Stromal Cells

Carlos Carmona-Fontaine, New York University, USA
Short Talk: Cell Cooperation in Cancer by Collective Catabolism of Extracellular Peptides

Anne Classen, Albert Ludwigs University Freiburg, Germany
Short Talk: A JNK-Dependent Cell Cycle Arrest in G2 Promotes Survival and Senescence-Associated Signaling in Tissue Stress

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Pre Function
17:00—17:45
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Laura A. Johnston, Columbia University, USA

Gines Morata, Universidad Autonoma de Madrid, Spain
The Two Faces of Cell Competition: Tumor-Suppressing or Tumor-Stimulating

17:45—19:00
Competition in Cancer
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Inigo Martincorena, Wellcome Trust Sanger Institute, UK

Yasuyuki Fujita, Hokkaido University, Japan
Sequential Oncogenic Mutations Profoundly Influence the Outcome of Cell Competition

Jamie L. Lahvic, University of California, Berkeley, USA
Short Talk: Mechanisms of Tumor Extrusion Maintain Epithelial Homeostasis

Harold E. Varmus, Weill Cornell Medical College, USA
Turning Clues from Cancer Genomics into Mechanisms of Cancer Development and Evolution

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
19:15—20:15
Dinner

Granhall
19:15—20:15
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

FRIDAY, MARCH 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD097895-01

Funding for this conference was made possible (in part) by 1R13HD097895-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676