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This meeting took place in 2019



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Signal Dynamics and Signal Integration in Development and Disease (J4)


Organizer(s) Nicolas Tapon, Liliana Attisano and Raphael Kopan
January 27—31, 2019
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 17, 2018
Abstract Deadline: Oct 25, 2018
Scholarship Deadline: Oct 17, 2018
Discounted Registration Deadline: Nov 28, 2018

Supported by the Directors' Fund


Summary of Meeting:
The discovery and study of the major developmental signaling pathways (Notch, Hh, Wnt, RTK) has illuminated how patterning and growth are controlled in metazoans. These pathways are reiteratively used during development and adult life, acting to maintain stem cells and direct tissue repair and regeneration. When they are disrupted, cancer develops. This conference embraces recent progress in quantitative biology, mathematical modelling, single cell analysis and intravital imaging. It also presents a major opportunity to bring together knowledge from developmental systems with adult homeostasis, regeneration and cancer, as well as to elucidate how different developmental signals are integrated to influence cellular decision-making processes. The pairing with the conference on Cellular Plasticity: Reprogramming, Regeneration, and Metaplasia enables an in-depth exploration of the parallels between plasticity/pluripotency in development, regeneration and disease. In summary, the conference aims to: 1) Explore the commonalities between signaling in development, regeneration, and homeostasis, 2) Leverage quantitative, single cell and systems biology to study the dynamics and integration of developmental signaling across scales, and 3) Highlight how perturbations in developmental pathways cause diseases such as cancer.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 1 in order to fully experience the meeting.

SUNDAY, JANUARY 27

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, JANUARY 28

07:00—08:00
Breakfast

Red Cloud/Shavano/Torreys
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Jason C. Mills, Washington University, USA

* Nicolas Tapon, Francis Crick Institute, UK

Hans C. Clevers, Hubrecht Institute, Netherlands
Lgr5 Stem Cell-Based Organoids in Human Disease

09:00—11:30
Plasticity and Signaling in Development and Homeostasis (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Michael B. O'Connor, University of Minnesota, Twin Cities, USA

* Anna Mae Diehl, Duke University, USA

Jayaraj Rajagopal, Massachusetts General Hospital, USA
The Airway Epithelial Ensemble

Coffee Break

Ophir Klein, University of California, San Francisco, USA
Renewal and Plasticity in Oral Epithelia

Valentina Greco, Yale School of Medicine, USA
Principles of Tissue Dynamics and Function Captured by Live Imaging

Erin N. Sanders, Stanford University, USA
Short Talk: Real-Time Kinetics of Notch-Mediated Fate Decisions during Organ Renewal

Shiyan Yu, Rutgers University-Newark, USA
Short Talk: Injury Induces Paneth Cell Plasticity

11:30—12:30
Meet the Editors (Joint)
Scientific progress depends on efficient mechanisms to select, quality control and share rigorous and reproducible research. This panel discussion aims to give an overview on the approaches different scientific publishers and journals take to accomplish these goals and will give ample space for discussion between editors and researchers on how the editorial and peer review process can be reformed to assess both the interest of the claims made and the reliability, reproducibility and integrity of the experimental data. The following aspects will be covered in particular: 1) the peer-review process put to test: current perspectives. 2) Data reproducibility and research ethics. 3) Data accessibility and pre-print servers. 4) Open Access or Open Science?

Grays/Longs Peak
* Daniel Klimmeck, EMBO Journal, Germany

* Sheila Chari, Cell Press, USA

Iain Dickson, Nature Reviews, UK

John F. Foley, Science Signaling, USA

Seema Grewal, Development, UK

Marie Bao, Cell Press, USA

Jessie Ann Le Good, Nature Communications, UK

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Red Cloud/Shavano/Torreys
13:00—22:00
Poster Viewing

Red Cloud/Shavano/Torreys
14:30—16:30
Workshop

Longs Peak
* Silvia Santos, Francis Crick Institute, UK

Julie B. Sneddon, University California, San Francisco, USA
Cell Fate Determination in Human Pancreatic Endocrine Development

Micha Sam Brickman Raredon, Yale University, USA
Cross-Species scRNAseq Analysis of Cell-Cell Connectomics in Lung

Jarod Zepp, University of Pennsylvania, USA
Epithelial to Mesenchymal Crosstalk during the Postnatal Phase of Lung Development Coordinates Lineage Commitment and Niche Formation

Oliver Wessely, Cleveland Clinic Foundation, USA
A Design-of-Experiment Approach Towards Differentiation of Human Pluripotent Stem Cells into Definitive Kidney Cell Lineages

Akiko Mammoto, Medical College of Wisconsin, USA
Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth through YAP1

14:30—16:30
Workshop

Grays Peak
* Chay T. Kuo, Duke University School of Medicine, USA

Lorin Olson, Oklahoma Medical Research Foundation, USA
Mosaic Mutant Analysis Identifies PDGFRa/PDGFRb as Regulators of Adipocyte Progenitor Cell Plasticity

Feng Chen, University of California, San Francisco, USA
Resolving the Contribution of Adult Liver Stem/Progenitor Cells to Hepatocyte Regeneration with a Dual AAV Vector System for Inducing Liver Injury and Lineage Tracing

Kenji Ito, University of Tokyo, Japan
Cancer Drug Screening Based on Refractoriness of Cancer Cell Reprogramming

Enric Llorens-Bobadilla, Karolinska Institute, Sweden
Programming Future Fate Decisions in the Glial Scar to Promote Spinal Cord Injury Repair

Agnieszka B. Bialkowska, Stony Brook University, USA
Krüppel-Like Factor 5 Plays an Important Role in Acinar-to-Ductal Metaplasia of the Pancreas

Oscar Pellon-Cardenas, Rutgers University, USA
CDX2 Loss Disrupts the Differentiation-Proliferation Balance during Initiation and Progression of Intestinal Tumors

Lianghui Zhang, University of Illinois at Chicago, USA
Differential Pathogen Response Mechanisms and Single Cell Heterogeneity in Endothelial Regeneration

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Quantitative Approaches and Signaling Networks
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Anna Kicheva, Institute of Science and Technology Austria, Austria

Michael Elowitz, California Institute of Technology, USA
Communication and Computation in Protein Circuits

Ertugrul M. Ozbudak, Cincinnati Children's Hospital Medical Center, USA
Spatial Fold-Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish

Mary N. Teruel, Stanford University, USA
Control of Cell Differentiation by Timing and Phase-Shifting of Physiological Oscillators

Jared Toettcher, Princeton University, USA
Short Talk: Cellular Optogenetics Reveals Principles of Cell Fate Control in the Early Drosophila Embryo

Amanda L. Zacharias, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Comprehensive Quantitative Analysis of Nuclear β-catenin in C. elegans Embryos Identifies a Novel Memory Mechanism for Gene Expression Diversification

17:00—19:00
Stem Cell Recruitment and Metaplasia
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Eunyoung Choi, Vanderbilt University Medical Center, USA

Calvin Kuo, Stanford University, USA
Intestinal Stem Cell Niches

James R. Goldenring, Vanderbilt University Medical Center, USA
Inflammatory Regulation of Metaplasia Induction in the Stomach

Jason C. Mills, Washington University, USA
Reserve Stem Cells Recruited by Paligenosis, an Evolutionarily Conserved Program

Melissa Hirose Wong, Oregon Health & Science University, USA
Short Talk: Macrophage-Cancer Stem Cell Fusion Underlies Cancer Cell Plasticity and Potentiates Metastatic Spread of Disease

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Red Cloud/Shavano/Torreys
19:30—22:00
Poster Session 1

Red Cloud/Shavano/Torreys

TUESDAY, JANUARY 29

07:00—08:00
Breakfast

Red Cloud/Shavano/Torreys
08:00—11:00
Signaling Dynamics
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Dan Shaye, University of Illinois at Chicago, USA

Vivian Li, Francis Crick Institute, UK
Wnt Signal Rregulation in Intestinal Stem Cells and Cancer

Deborah L. Gumucio, University of Michigan, USA
Dynamic Roles for WNT5a During Morphogenesis of the Mouse Fetal Intestine

Coffee Break

Raphael Kopan, University of Cincinnati College of Medicine, USA
A Role for Notch Dimerization and CSL Binding-Site Architecture in Mammalian Development and Tissue Maintenance

Victoria Ng, Vanderbilt University, USA
Short Talk: The USP46 Complex Promotes Wnt Signaling by Blocking Receptor Turnover

Sergi Regot, Johns Hopkins University, USA
Short Talk: Single Cell Analysis of MAPK Signaling Dynamics in Multicellular Systems

David Sprinzak, Tel Aviv University, Israel
Short Talk: Localized Feedbacks on Fat4-Ds1 Complexes Underlie Planar Cell Polarity

Kaelyn Sumigray, Duke University School of Medicine, USA
Short Talk: Morphogenesis and Compartmentalization of the Mammalian Intestine

08:00—11:15
Cancer and Plasticity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Blair B. Madison, Washington University, USA

Arjun Raj, University of Pennsylvania, USA
Controlling Cellular Plasticity in Cancer

Ben Z. Stanger, University of Pennsylvania, USA
Epithelial-Mesenchymal Plasticity in Cancer Cell Invasion and Metastasis

Coffee Break

Carla F. Kim, Boston Children's Hospital, USA
Regulation of Progenitor Cells in the Adult Lung

Cory T. Abate-Shen, Columbia University Medical Center, USA
Cellular Plasticity in Prostate Cancer

Rohit Chandwani, Weill Cornell Medicine, USA
Short Talk: Chromatin Dynamics in vivo Reveal the Complexity of Cell Fate Transitions in Pancreatic Cancer Initiation

Ellen M. Langer, Oregon Health & Science University, USA
Short Talk: The Prolyl Isomerase PIN1 Plays a Critical Role in Pancreatic Stellate Cell Plasticity to Impact Tumor Development

Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Regenerative Origin of Metastasis-Initiating Cells

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Red Cloud/Shavano/Torreys
13:00—22:00
Poster Viewing

Red Cloud/Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Morphogen Gradients in Growth and Patterning
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Kaelyn Sumigray, Duke University School of Medicine, USA

Caroline S. Hill, Francis Crick Institute, UK
Self-Organizing Pattern Formation in Endoderm Specification in Zebrafish

Anna Kicheva, Institute of Science and Technology Austria, Austria
Coordination of Progenitor Specification and Growth in the Developing Spinal Cord

Jean-Paul B. Vincent, Francis Crick Institute, UK
Coordination of Growth and Patterning in a Developing Epithelium

Jennifer Kong, Stanford University, USA
Short Talk: Molecular Mechanisms that Regulate Target Cell Sensitivity to Hedgehog Morphogens

Shinji Takada, National Institute for Basic Biology, Japan
Short Talk: Extracellular Dynamics and Diffusion Range of Wnt Protein Complex in Xenopus Embryos

17:00—19:00
Reprogramming Cells to Assemble and Repair Organs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Sydney Shaffer, University of Pennsylvania, USA

Jason R. Spence, University of Michigan Health System, USA
Intestinal Organoids

Takanori Takebe, Yokohama City University / Cincinnati Children's Hospital Medical Center, Japan
Next-Gen Organoids from Pluripotency

Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Intestinal Stem Cells in Cancer

Purushothama Rao Rao Tata, Duke University School of Medicine, USA
Short Talk: Stem Cells and Reserve Stem Cells in the Lung

Qiong Wang, City of Hope/BRI, USA
Short Talk: Reversible Dedifferentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Red Cloud/Shavano/Torreys
19:30—22:00
Poster Session 2

Red Cloud/Shavano/Torreys

WEDNESDAY, JANUARY 30

07:00—08:00
Breakfast

Red Cloud/Shavano/Torreys
08:00—11:00
Plasticity and Signaling in Regeneration and Tumorigenesis (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Caroline S. Hill, Francis Crick Institute, UK

* Thea D. Tlsty, University of California, San Francisco, USA

Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Revival Stem Cells Regenerate the Intestine

Maike Sander, University of California, San Diego, USA
Deconstructing Endodermal Organ Development to Reconstruct Organs From Stem Cells

Coffee Break

Stacey S. Huppert, Cincinnati Children’s Hospital Medical Center, USA
Building a Functional Biliary System via Hepatocyte Plasticity

Owen J. Sansom, Beatson Institute of Cancer Research, UK
Reserve Stem Cells and Intestinal Tumorigenesis: Foetal Progenitors and Microbiome in Colorectal Cancer

Margaret E. Magaletta, University of Massachusetts Medical School, USA
Short Talk: Single Cell Transcriptomic Analysis Resolves Dynamics of Developing Pharyngeal Endoderm

P. Duc Si Dong, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Biliary Paucity Due Jagged/Notch Loss is Reversible via a Novel Non-Hepatic Multipotent Cell Population

11:00—12:00
Panel: Nomenclature in Cell Plasticity: "Plasticity," "Dedifferentiation," "Transdifferentiation," "Reprogramming," "Reversion," "Paligenosis" – Can We Agree What These Mean?
This session will seek to examine the utility of critical terms relating to cellular plasticity through an open discussion among the panelists and the audience. Particular topics will include: 1) What is dedifferentiation?; 2) What is transdifferentiation?; 3) Are more specific terms required to describe plasticity pathways?; and 4) What are the implications of terms such as metaplasia?

Grays/Longs Peak
James R. Goldenring, Vanderbilt University Medical Center, USA

Anna Mae Diehl, Duke University, USA

Jason C. Mills, Washington University, USA

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Red Cloud/Shavano/Torreys
13:00—22:00
Poster Viewing

Red Cloud/Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Cell Competition and Mechanical Interactions
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Tadanori Mammoto, Medical College of Wisconsin, USA

Eugenia Piddini, University of Bristol, UK
Mechanical Cell Competition: Mechanisms and Implications for Epithelial Biology

Miguel Torres, Centro Nacional de Investigaciones Cardiovasculares, Spain
Cell Competition in Mammalian Development and Tissue Homeostasis

Nicolas Tapon, Francis Crick Institute, UK
Growth Control and Hippo Signaling in the Drosophila Abdomen

Giulia Pilia, Uppsala Universitet, Sweden
Short Talk: Ack1 Is a Mechanoresponsive Kinase Required for Regulation of Yap/Taz

Anne-Marie Pret, University of Versailles St Quentin-en-Yvelines, France
Short Talk: JAK/STAT Signaling and Epithelial Homeostasis in Drosophila

17:00—19:00
Transcriptional Regulation of Cell Plasticity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Janel Kopp, University of British Columbia, Canada

Ramesh A. Shivdasani, Dana-Farber Cancer Institute, USA
Epigenetic Regulation of Gut Development and Plasticity

Scott T. Magness, University of North Carolina at Chapel Hill, USA
Sox9 Regulates Reserve Intestinal Stem Cell Function

Michele A. Battle, Medical College of Wisconsin, USA
Transcriptional Regulation of Barrett’s Metaplasia

William Zacharias, Cincinnati Children's Hospital, USA
Short Talk: Defining the Gene Regulatory Networks Underlying Regenerative Capacity in Alveolar Epithelial Progenitor Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Red Cloud/Shavano/Torreys
19:30—22:00
Poster Session 3

Red Cloud/Shavano/Torreys

THURSDAY, JANUARY 31

07:00—08:00
Breakfast

Red Cloud/Shavano/Torreys
08:00—11:00
Developmental Signaling and Disease
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Thijs Jasper Hagenbeek, Genentech, Inc., USA

Adolfo Ferrando, Columbia University, USA
Notch in T-Cell Acute Lymphoblastic Leukemia

Feng Cong, Novartis Institutes for BioMedical Research, USA
Drug Discovery for the Wnt, TGFß/BMP, and HIPPO Pathways

Coffee Break

Kun-Liang Guan, University of California, San Diego, USA
Hippo Signaling in Cancer

Vincent Idone, Regeneron Pharmaceuticals Inc., USA
Activin Ligand Traps in Bone Disease Treatment

Zlatko Trajanoski, Medical University of Innsbruck, Austria
Short Talk: Perturbation Biology of Colorectal Cancer Organoids Reveals Patient-Specific Signaling Rewiring and Interference with Immunity

Dominique Celeste Mitchell, University of California, San Francisco, USA
Short Talk: Small Molecule Activation of LKB1 Reveals Multiphasic Hippo Pathway Signal Buffering

08:00—11:00
Injury, Inflammation and Regeneration
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Leonard H. Augenlicht, Albert Einstein College of Medicine, USA

Irene Miguel-Aliaga, Imperial College London, UK
Sex Differences in Organ Plasticity

Xin Sun, University of California, San Diego, USA
Neural-Immune Niches in the Airway

Coffee Break

Juanita L. Merchant, University of Arizona College of Medicine, USA
How Do Immune Cells Reprogram the Epithelium?

Anil K. Rustgi, University of Pennsylvania, USA
Metaplasia in Esophagus and Pancreas

Peter J. Dempsey, University of Colorado Denver, USA
Short Talk: Cellular Plasticity of Defa4-Cre-Expressing Paneth Cells

Won Jae Huh, Vanderbilt University Medical Center, USA
Short Talk: Transforming Growth Factor-α (TGFα) Overexpression Induces Spasmolytic Polypeptide Expressing Metaplasia

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Integration of Developmental Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Raphael Kopan, University of Cincinnati College of Medicine, USA

Liliana Attisano, University of Toronto, Canada
NUAK2, a Feed Forward Regulator of the Hippo Pathway during Tumorigenesis

Norbert Perrimon, Harvard Medical School, USA
Insights on the Role of Ion Channels in the Drosophila Gut Epithelium

Lukasz Bugaj, University of Pennsylvania, USA
High-Throughput Multicolor Optogenetics for the Systematic Dissection of Signal Dynamics and Integration

Andrei V. Karginov, University of Illinois at Chicago, USA
Short Talk: Interrogation of Signaling Pathways using Light-Regulated Protein Kinases

17:00—18:45
Applications of Cell Plasticity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Nicholas Zachos, Johns Hopkins University School of Medicine, USA

Joe Q. Zhou, Weill Cornell Medical College, USA
Making Insulin-Secreting Cells from Intestine

Darrell N. Kotton, Boston University, USA
Pluripotent Stem Cell Models of Lung Development and Disease

Wendy M. McKimpson, Columbia University, USA
Short Talk: Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Longs Peak
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Red Cloud/Shavano/Torreys
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Red Cloud/Shavano/Torreys

FRIDAY, FEBRUARY 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HD096834-01

Funding for this conference was made possible (in part) by 1 R13 HD096834-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179