Beaver Run Resort Floorplan

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This meeting took place in 2018



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Exosomes/Microvesicles: Heterogeneity, Biogenesis, Function and Therapeutic Developments (E2)


Organizer(s) Crislyn D'Souza-Schorey and David Lyden
June 4—8, 2018
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Feb 6, 2018
Abstract Deadline: Mar 6, 2018
Scholarship Deadline: Feb 6, 2018
Discounted Registration Deadline: Apr 10, 2018

Supported by Directors' Fund

Summary of Meeting:
Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication in both local and distant microenvironments, during normal development and physiological processes, as well as in orchestrating systemic pathophysiological events. EVs comprise a large group of heterogeneous particles, including exosomes and microvesicles, and are released from virtually all cell types. Differing in size, macromolecular composition, and mechanism of formation, subpopulations of extracellular vesicles contain biologically active molecules, such as nucleic acids (DNA, mRNA, microRNA and other noncoding RNAs), proteins (transmembrane receptors, transcription factors, enzymes, extracellular matrix proteins), and lipids that can in part or in sum contribute to the functional capabilities of the vesicle itself, or the reprogramming of target cells that interact with EVs. This complexity presents significant challenges to determining the functional roles of the various EV populations during both normal and pathological processes. Conference sessions will focus on EV cargo and composition; the role of EVs in development; EV-mediated immune regulation; EVs in cancer and metastasis, neurodegeneration and infectious disease; emerging technologies; and harnessing the therapeutic potential of EVs. The overall goal is to deepen our understanding of the structural and functional complexity of extracellular vesicles, their biogenesis and function in health and disease, cargo enrichment, potential as ideal biomarkers, and breakthroughs in their use as therapeutic targets/agents.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Monday, June 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, June 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, June 9 in order to fully experience the meeting.

MONDAY, JUNE 4

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

TUESDAY, JUNE 5

07:30—08:30
Breakfast

Summit Gallery
08:00—08:30
Poster Setup

Breckenridge Ballroom
08:30—17:00
Poster Viewing

Breckenridge Ballroom
08:30—11:45
EV Cargo and Delivery
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Xandra O. Breakefield, Massachusetts General Hospital, USA
Functional Delivery by EVs

Dolores Di Vizio, Cedars-Sinai Medical Center, USA
Oncosomes in Prostate Cancer

Coffee Break

Bruno Costa-Silva, Champalimaud Foundation, Portugal
Population Analysis of Exosomes

James Clancy, University of Notre Dame, USA
Regulated Cargo Delivery to Tumor Microvesicles: How Do Cells Put their Messages in a Bottle?

Andrew M. Leidal, University of California, San Francisco, USA
Short Talk: The Autophagy Conjugation Machinery Specifies the Loading of RNA-Binding Proteins into Extracellular Microvesicles

Michael Hantak, Loyola University Stritch School of Medicine, USA
Short Talk: Enhancers and Suppressors of EV - Mediated Intercellular Cargo Transfer

11:45—12:30
Lunch

Breckenridge Ballroom
12:00—14:30
Poster Session 1

Breckenridge Ballroom
14:30—16:30
Panel: Meet the Editors

Colorado Ballroom
* David Lyden, Weill Cornell Medical College, USA

Gemma Kathleen Alderton, Science Magazine, UK

Alexia-Ileana Zaromytidou, Nature Cell Biology, UK

Simona Fiorani, Nature Communications, UK

Elisabetta Argenzio, EMBO Journal, Germany

Petra Gross, Journal of Cell Science, UK

Masha Gelfand, Cell Press, USA

16:30—17:00
Coffee Available

Foyer
17:00—19:15
EVs and Regulation of the Immune Response
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Marca H.M. Wauben, Universiteit Utrecht, Netherlands
Cross-Organism Communication: The Immune Regulatory Role of Breast Milk Extracellular Vesicles

Susanne Gabrielsson, Karolinska Institutet, Sweden
Potentiating Immune Responses to Exosomes for Cancer Therapy

Olga V. Volpert, University of Texas MD Anderson Cancer Center, USA
The Dichotomy of the Innate Immune Response to Cancer Exosomes

Simon Heidegger, Klinikum Rechts der Isar, Technical University Munich, Germany
Short Talk: Targeting Tumor-Intrinsic RIG-I Signaling Initiates the Release of Immunogenic Extracellular Vesicles that Mediate T Cell-Based Antitumor Immunity

Jessy S. Deshane, University of Alabama at Birmingham, USA
Short Talk: Extracellular Vesicles from Airways of Asthmatics Promote Th2 and Th17 Polarization

19:15
On Own for Dinner


WEDNESDAY, JUNE 6

07:30—08:30
Breakfast

Summit Gallery
08:30—11:45
EVs and Cancer I (Tumor Growth and Dissemination)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
Michael J. Powell, DiaCarta, Inc., USA
Precision Nucleic Acid Based Molecular Diagnostics Powered by Xenonucleic Acids

* Richard A. Cerione, Cornell University, USA
Probing the Mechanisms of Extracellular Vesicle Biogenesis and Function in Cancer and Development

Coffee Break

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Generation and Testing of Clinical-Grade Engineered Exosomes to Facilitate Therapeutic Targeting of Oncogenic KRAS in Pancreatic Cancer

Clotilde Théry, Institut Curie, France
Biochemical and Functional Heterogeneity of Extracellular Vesicles in Cancer-Immune Crosstalk

Leonora Balaj, Massachusetts General Hospital, USA
Short Talk: Longitudinal Analysis of Serum-Derived Extracellular RNA for Monitoring of Treatment Response to Targeted Therapy in Glioblastomas

Haiying Zhang, Cornell University, USA
Short Talk: Identification of Distinct Nanoparticles and Subsets of Extracellular Vesicles by Asymmetric-Flow Field-Flow Fractionation

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Colorado Ballroom Foyer
13:00—22:00
Poster Viewing

Colorado Ballroom Foyer
14:30—16:30
Workshop 1

Colorado Ballroom
* Crislyn D'Souza-Schorey, University of Notre Dame, USA

Philip D. Stahl, Washington University in St. Louis, School of Medicine, USA
Special Lecture: The Exosome Paradigm of Intercellular Communication

John Pena, Weill Cornell Medical College, USA
Enhancing Extracellular Vesicle Imaging in Biological Fluids and Tissues using a Non-Reversible Fixative

Mikael Klingeborn, Duke University, USA
Retinal Exosomes as Therapeutic Targets and Diagnostic Biomarkers

Albert Lu, Stanford University, USA
A Genome-Wide CRISPR Screen using Barcoded-MicroRNAs Enables Systematic Interrogation of Extracellular Vesicle Biology

16:30—17:00
Coffee Available

Foyer
17:00—19:00
EVs in Neurobiology: Neurodevelopment, Degeneration and Regeneration
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
Andrew Hill, La Trobe University, Australia
Extracellular Vesicles - Their Role in Neurodegenerative Disease Pathogenesis

* Stefan Momma, Frankfurt University Hospital, Germany
Extracellular Vesicle-Mediated Communication from Blood to Brain Is Triggered by Neural Activity in vivo

Tsuneya Ikezu, Boston University School of Medicine, USA
Recent Progress in EV Biology in Neurodegenerative Disorders

Jason Shepherd, University of Utah, USA
Short Talk: Viral-Like Mechanisms of Neuronal Extracellular Vesicle Biogenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Colorado Ballroom Foyer

THURSDAY, JUNE 7

07:30—08:30
Breakfast

Summit Gallery
08:30—11:30
EVs and Cancer II (Metastases)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
David Lyden, Weill Cornell Medical College, USA
The Role of Tumor-Secreted Exosomes in Cancer Metastasis

* Janusz Rak, McGill University, Canada
Extracellular Vesicles and Brain Malignancies

Coffee Break

Takahiro Ochiya, National Cancer Center Research Institute, Japan
EV-Mediated Micromanaging of Tumor Metastasis

Dihua Yu, University of Texas MD Anderson Cancer Center, USA
Tumor Microenvironment-Derived Exosomes in Metastasis and Immune Activation

Viktor Fleming, German Cancer Research Center, Germany
Short Talk: Induction of Myeloid-Derived Suppressor Cells via Tumor-Derived Extracellular Vesicles in Malignant Melanoma

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Colorado Ballroom Foyer
13:00—22:00
Poster Viewing

Colorado Ballroom Foyer
14:30—16:30
Workshop 2

Colorado Ballroom
* Alissa M. Weaver, Vanderbilt University School of Medicine, USA
Investigating the Role of Exosome Secretion in Cellular Migration by Live Imaging

Amy E. Baek, University of Illinois at Urbana-Champaign, USA
Cholesterol Metabolite Promotes Breast Cancer Progression via Extracellular Vesicles

Jörg Votteler, University of Utah, USA
Designed Proteins Induce Formation of Nanocage-Containing Vesicles

Ana O'Loghlen, Blizard Institute, UK
The Bystander Effect of Exosomes in Senescence and Aging

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Current and Emerging Technologies
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
Olivier De Wever, University of Ghent, Belgium
Standardized Analysis of Extracellular Vesicles in Liquid Biopsies

Huang-Ge Zhang, University of Louisville, USA
Development of Three Generations of Edible Plant Exosome-Like Nanovectors for Therapy

* David Issadore, University of Pennsylvania, USA
Optofluidics Platforms for Exosome-Based Diagnostics

Jina Ko, University of Pennsylvania, USA
Short Talk: Multiplexed Exosome Diagnostics Using Machine Learning Combined Nanofluidics

Robert R. Kitchen, Exosome Diagnostics, USA
Short Talk: A High-Performance Urine Exosomal-mRNA Signature to Rule-Out Healthy Individuals Suspected of Bladder Cancer

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Colorado Ballroom Foyer

FRIDAY, JUNE 8

07:30—08:30
Breakfast

Summit Gallery
08:30—11:30
EVs in Host-Pathogen Interactions
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
Neta Regev-Rudzki, Weizmann Institute of Science, Israel
Malaria Parasites Regulate Secretion of Exosomes Carrying Distinct Cargo

* Jeff S. Schorey, University of Notre Dame, USA
Extracellular Vesicles: Friend or Foe in the Immune Response against a Mycobacterium tuberculosis Infection

Coffee Break

Ana Claudia Torrecilhas, Universidade Federal de São Paulo, Brazil
Extracellular Vesicles Modulate Innate Immune Response in Protozoa Infection

Marlene Dreux, CIRI, International Center for Infectology Research, France
Flavor of Flavivirus by Plasmacytoid Dendritic Cells

João Pedra, University of Maryland School of Medicine, USA
Short Talk: Trans-Kingdom Intercommunication at the Vector-Pathogen-Host Interface

Sreenivas Gannavaram, US Food and Drug Administration, USA
Short Talk: Role of Exosomal MicroRNAs in Shaping Protective Immunity Induced by Live Attenuated Leishmania Vaccines

11:30—17:00
On Own for Lunch

15:00—16:30
Meet the NIH Staff: Opportunities

Colorado Ballroom
Aaron Pawlyk, NIDDK, National Institutes of Health, USA
Overview of the NIH and NIDDK

Olivier Blondel, NIDDK, National Institutes of Health, USA
Exosome/Microvesicle-Relevant Opportunities at the NIDDK

Matthew R. Young, NCI, National Institutes of Health, USA
Overview and Exosome/Microvesicle-Relevant Opportunities at the NCI

16:30—17:00
Coffee Available

Foyer
17:00—18:45
EV Therapeutics
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Johan Skog, Exosome Diagnostics, Inc., USA
Current State of Exosome-Based Diagnostics

Jan Lötvall, University of Gothenburg, Sweden
Potential of Extracellular Vesicles for Therapeutic Uses

Eva Rohde, Paracelsus Medical University Salzburg, Austria
Pharmaceutical Engineering and Clinical Testing of Stromal Cell-Derived Extracellular Vesicles

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Breckenridge Ballroom

SATURDAY, JUNE 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support from these exhibitors at this conference:

Izon Science NanoView Biosciences Inc.
The Paul G. Allen Frontiers Group
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA228495-01

Funding for this conference was made possible (in part) by 1R13CA228495-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

University of Notre Dame

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676