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This meeting took place in 2018



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Frontiers in Islet Biology and Diabetes (B3)


Organizer(s) Matthias Hebrok, Seung K. Kim, Felicia Pagliuca and Anil Bhushan
February 4—8, 2018
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 5, 2017
Abstract Deadline: Nov 7, 2017
Scholarship Deadline: Oct 5, 2017
Discounted Registration Deadline: Dec 7, 2017

Sponsored by Novo Nordisk A/S

Summary of Meeting:
Diabetes mellitus is a pandemic disease rooted in defects of multiple organs. Autoimmune destruction of pancreatic islet beta cells (type 1 diabetes) or relentless deterioration in beta cell function from excessive systemic insulin demand (type 2 diabetes) culminates in severe or lethal metabolic derangement. Inter-organ signaling has emerged as a crucial mechanism for achieving metabolic balance, including responses by peripheral insulin-target organs that, in turn, remotely regulate islet activity. This meeting will focus on crucial aspects of beta cell biology, including islet development, pancreas cellular plasticity, beta cell surrogate generation from stem cells, novel gene editing technologies, and immune-islet interactions, as well as translation of basic discoveries into novel therapeutic trials for diabetic patients. This meeting aims to encourage the presentation of novel concepts, foster useful interactions between participants from academia and industry, and accelerate interdisciplinary approaches in diabetes research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 8 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 9 in order to fully experience the meeting.

SUNDAY, FEBRUARY 4

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 5

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Matthias Hebrok, University of California, San Francisco, USA

Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors, Diabetes and Beyond

09:00—11:30
Beta Cell Development/Maturation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Lori Sussel, University of Colorado Anschutz Medical Campus, USA

Danwei Huangfu, Memorial Sloan Kettering Cancer Institute, USA
Human Pancreas Development Through the Lens of Pluripotent Stem Cells

Coffee Break

Chris Wright, Vanderbilt University Medical Center, USA
Pancreatic Endocrine-Cell Birth: Focal Cell-Intrinsic Neurog3-Independent Morphogenetic Programs Linked to Epithelial Feedback, and Lineage-Priming as a Progenitor-Partitioning Mechanism

Joon Ho Moon, Korea Advanced Institute of Science & Technology, South Korea
Short Talk: Serotonin Regulates β-cell Proliferation during Perinatal Period

Roland W. Stein, Vanderbilt University Medical Center, USA
Recruitment of the Swi/Snf Chromatin Remodeling Complex by Pdx1 Is Required for Regulating Pancreas Development and Adult Islet β Cell Function in vivo

Chengran Xu, Peking University, China
Short Talk: Deciphering Pancreatic Islet β-Cell and α-Cell Maturation Pathways and Characteristic Features at the Single-Cell Level

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Human Islet Biology
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Roland W. Stein, Vanderbilt University Medical Center, USA

Alvin C. Powers, Vanderbilt University School of Medicine, USA
Lessons from Early Human Pancreatic Islet Development and Function

Anath Shalev, University of Alabama at Birmingham, USA
Clinical Trials Promoting beta Cell Survival

Peter C. Butler, University of California, Los Angeles, USA
The Mitochondrial Network and Function in Beta Cells in Health and Type 2 Diabetes

Marta Perez-Alcantara, University of Oxford, UK
Short Talk: Human Islet Differentiation Model Highlights Developmental Mechanisms Contributing to Type 2 Diabetes Pathology

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Alpha Cells/Intracellular Islet Communication
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Seung K. Kim, Stanford University, USA

Patrick MacDonald, University of Alberta, Canada
Alpha Cell Function and Identity in Human T2D

Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Regulation of Islet Cell Fates by Long Noncoding RNAs

Coffee Break

Francis C. Lynn, University of British Columbia, Canada
Expression of Npas4 in Activated β-cells Represses the α-Cell Fate

Mark O. Huising, University of California, Davis, USA
A Urocortin 3-Mediated Negative Feedback Loop Controls Insulin Secretion to Determine the Homeostatic Set Point for Blood Glucose

Diana E. Stanescu, University of Pennsylvania, Children's Hospital of Philadelphia, USA
Short Talk: The Role of SLC38A5 in Pancreatic alpha Cell Development

Megan Capozzi, Duke University, USA
Short Talk: α Cells Control β Cell Function

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Emerging Technologies and Disease Modeling
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Guy A. Rutter, Imperial College London, UK

Danny Hung-Chieh Chou, University of Utah, USA
Novel Ultrafast-Acting Insulin

Andrew F. Stewart, Mount Sinai School of Medicine, USA
Synergistic Increases in Adult Human Beta Cell Proliferation Induced By Combined Small Molecule Treatment

Clive N. Svendsen, Cedars-Sinai Regenerative Medicine Institute, USA
Using Organ-On-Chip Combined with Induced Pluripotent Stem Cells to Model Human Disease

Alice Anna Tomei, Diabetes Research Institute, USA
Short Talk: Conformal Coating of Stem-Cell-Derived Insulin-Secreting Cells for Transplantation in Confined Well-Vascularized Sites without Immunosuppression

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, FEBRUARY 7

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Progenitor to Islet Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Markus Grompe, Oregon Health & Science University, USA
Reprogramming Approaches for Beta-Cell Replacement

Anil Bhushan, University of California, San Francisco, USA
A New Paradigm for T1D Pathogenesis

Coffee Break

Matthias Hebrok, University of California, San Francisco, USA
Functional Analysis of Human Stem Cell Derived beta Cells

Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Beta Cell Heterogeneity and Maturation

Fiona M. Docherty, University of Colorado Denver, USA
Short Talk: Identification of Factors Involved in Maintenance and Differentiation of Uncommitted Human Pancreatic Endoderm

Carolina Rosselot, Icahn School of Medicine at Mount Sinai, USA
Short Talk: c-Myc Regulation of Adaptive Beta Cell Proliferation and Expansion: Impairment in Type 2 Diabetes

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
14:30—16:30
Workshop 1: Single Cell Analysis of Islet Cell Constituencies
This workshop will discuss the latest technological advances and transformative discoveries in the area of single cell analysis. The focus will be on approaches that further our understanding of cell heterogeneity in the islet and immune cells during the development of diabetes.

Grays Peak
* Julie B. Sneddon, University California, San Francisco, USA
Lineage Dynamics of Pancreatic Development at Single-Cell Resolution

Carmen Argmann, Icahn School of Medicine at Mount Sinai, USA
Integrative Analysis of Bulk and Single Cell Sequence Data of Human Insulinomas to Reveal Beta Cell Mitogenic Candidate Genes

JaeAnn Dwulet, University of Colorado Denver, USA
Subpopulations of β-cells Play a Disproportionate Role in Multicellular Islet Dynamics

Nathalie Groen, Leiden University Medical Center, Netherlands
Exploring Human Pancreatic β-Cell Plasticity using Single-cell RNA Sequencing

Nicole A. Krentz, , Canada
Single Cell Transcriptome Profiling of the Mouse and Human Endocrine Pancreas Lineages

Yan Li, Case Western Reserve University, USA
High-Throughput Single Cell Transcriptome Analysis and CRISPR Screen Identify Key Beta Cell-Specific Disease Genes

Nils Wierup, Lund University, Sweden
Multiple Type 2 Diabetes Genes and Functional Genetic Networks Identified using Single-cell RNA-sequencing of Human Pancreatic Islets

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Inter-Organ Signaling Islet Biology
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Anil Bhushan, University of California, San Francisco, USA

Guy A. Rutter, Imperial College London, UK
Role and Regulation of Beta Cell Pacemakers

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Liver-Derived Signals Regulating beta Cell Function

Seung K. Kim, Stanford University, USA
Evidence that Neuromedin U Is a Mammalian Decretin Hormone

Limor Landsman, Tel Aviv University, Israel
Short Talk: Pancreatic Pericytes Support beta-cell Function in a Tcf7l2-dependent Manner

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, FEBRUARY 8

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Immunology/Clinical Trials
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Felicia Pagliuca, Semma Therapeutics, Inc, USA

Anette G. Ziegler, Helmholtz Zentrum München, Germany
Prevention, Identification and Treatment of Early-Stage Type 1 Diabetes

Kevan C. Herold, Yale University, USA
Autoimmune Diabetes and Endocrinopathies Induced by Checkpoint Inhibitors

Coffee Break

Everett H. Meyer, Stanford University, USA
CAR T-Cell Immunomodulation in Diabetes

Sahar Keshvari, University of Queensland, Australia
Short Talk: Development of Interleukin-22-Based Therapy for Type 2 Diabetes

Sushant Bhatnagar, University of Alabama at Birmingham, USA
Short Talk: The Complement 1q-Like 3 Secreted Protein Acts as an Inhibitor of Insulin Secretion from Pancreatic β Cells

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 2: New Tools and Technologies for Diabetes Research
This workshop will explore how bioinformatics can help to better understand the genetic and epigenetic basis of diabetes and how using data analytics will foster efforts to create a precision medicine approach to diabetes therapies.

Grays Peak
* Olov Andersson, Karolinska Institutet, Sweden
In vivo Drug Discovery for Increasing the Number of Incretin Expressing Cells to Reinforce Glucose Control by the Gut-Pancreas Axis

Ronan Russell, University California, San Francisco, USA
Genome Editing in hPSCs Reveals an Important Role for MAFB in Human Beta Cell Formation

Heshan Peiris, Stanford University School of Medicine, USA
Conditional Genetics and Human Islet Studies to Discover Diabetes Risk Gene Function

Jonathan D. Douros, Duke University, USA
Vertical Sleeve Gastrectomy (VSG) Rapidly and Weight-Independently Enhances Intrinsic Cell Triggering and Amplifies Pathways for Insulin Secretion

Gregory Michael Ku, University of California, San Francisco, USA
A Genetic Interaction Map of Insulin Production Identifies Mfi as a Novel Inhibitor of Mitochondrial Fission

Masaya Oshima, INSERM, France
Viral-Like Infection Induces Human β Cell Dedifferentiation

Sophie Bauer, TissUse GmbH, Germany
Functional Coupling of Human Pancreatic Islet Microtissues and Liver Spheroids in a Microphysiological System: Towards a Novel Human ex vivo Model of Type 2 Diabetes

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Bioengineering/Encapsulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Matthias Hebrok, University of California, San Francisco, USA

Tejal A. Desai, University of California, San Francisco, USA
Nanoporous Thin Film Devices for Islet Encapsulation

Felicia Pagliuca, Semma Therapeutics, Inc, USA
Development of a Stem Cell-Derived Pancreatic Islet Cell Therapy for Diabetes

Cherie Stabler, University of Florida, USA
Engineering Bioactive Encapsulation Platforms for Islet Transplantation

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, FEBRUARY 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Novo Nordisk A/S

We gratefully acknowledge additional support from these exhibitors at this conference:

Mercodia, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK104616-03

Funding for this conference was made possible (in part) by 5R13DK104616-03 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


National Institutes of Health

Grant No. 5R13DK104616-04

Funding for this conference was made possible (in part) by 5R13DK104616-04 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

InSphero Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676