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This meeting took place in 2018



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Translational Systems Immunology (A9)


Organizer(s) Sally John, Soumya Raychaudhuri, Michael Vincent and Mark M. Davis
January 28—February 1, 2018
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Oct 2, 2017
Abstract Deadline: Oct 31, 2017
Scholarship Deadline: Oct 2, 2017
Discounted Registration Deadline: Dec 1, 2017

Sponsored by AbbVie Inc., Biogen, Bioverativ Therapeutics, Merck & Co., Inc. and Theravance Biopharma

Summary of Meeting:
Advances in large-scale data acquisition, immune phenotyping and computational biology are transforming immunology research and allowing unprecedented insights into the networks, pathways and systems that influence human health and disease. This conference will cover the exciting technology advances that are enhancing our ability to elucidate human immune function and networks as well as practical applications in drug and biomarker discovery and patient stratification. The meeting begins with a look at progress in human genetics and the use of sequencing to assign functional mutations to rare human immune phenotypes. The impact of common variants on immune function requires larger sample sizes, and speakers will cover how genome-wide high-throughput genomics in combination with detailed phenotyping and physiologically relevant perturbations are providing foundational data sets that allow an unbiased view of immune function in cells and tissues. Also discussed will be emerging computational and analytical methods that enable integration and interpretation of high-content molecular data. The meeting will then move on to look at the application of these technological advances, expanding investigation to study the immune response in tissues and organs to enable a deeper understanding of interaction between immune and non-immune cells and their respective roles in disease states. Critical to clinical progress is the translation of systems immunology research into novel therapies and diagnostic or prognostic tests. Sessions themed around infectious disease and vaccine development advances in immune-oncology and patient stratification in complex disease and treatment response aim to provide depth from foundational science to clinical translation. Finally, a key goal is fostering collaboration across disciplines and the development of novel ideas. The meeting will be relevant for immunologists, computational biologists and clinicians with an interest in molecular characterization of the immune system.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.

SUNDAY, JANUARY 28

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, JANUARY 29

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
* Sally John, Biogen, USA

Sarah Teichmann, Wellcome Trust Sanger Institute, UK
Immunogenomics One Cell at a Time

09:00—11:30
Human Phenotypic Validation via Rare Genetic Mutations
Meeting has ended...abstracts no longer viewable online.
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.

Ballroom 1-2
* Sally John, Biogen, USA

Danish Saleheen, University of Pennsylvania, USA
Human Knockout Program

Coffee Break

Helen C. Su, NIAID, National Institutes of Health, USA
Elucidating Molecular Mechanisms of a Novel Inherited Immunodeficiency-Immunodysregulation Disorder

Hakon Hakonarson, Children's Hospital of Philadelphia, USA
Exome Sequencing to Diagnosis and Treat Pediatric Immune Disease

Cecilia Dominguez Conde, CeMM/LBI-RUD, Austria
Short Talk: Insights into DOCK2 Deficiency through the Analysis of Protein Interactions

Michael P. O'Connell, NIAID, National Institutes of Health, USA
Short Talk: EXTL1- and NDST2-mediated Regulation of Allergic Disease

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Ballroom 3
13:00—22:00
Poster Viewing

Ballroom 3
14:30—16:30
Workshop 1: Translation from Mice to Man: Friendly Debate
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.

Ballroom 1-2
* Michael Vincent, Pfizer Inc., USA

* Mark M. Davis, ITI, USA

Jeffrey Barrett, Wellcome Trust Sanger Institute, UK
Using Human Genetics for Target Discovery in Inflammatory Bowel Disease

Richard M. Siegel, NIAMS, National Institutes of Health, USA
A Systems Approach to Defining Contributions of TNF-Family Cytokines to Autoimmune Disease Susceptibility Reveals a Protective Role for TL1A/TNFSF15 in IBD

Adam Laing, King's College London, UK
Immune Parameters Are Constrained within a Multidimensional Shape that Describes Immune Competence

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Genetics and Epigenetics Variation in Human Immune Traits
Meeting has ended...abstracts no longer viewable online.
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.

Ballroom 1-2
* Sally John, Biogen, USA

Julian C. Knight, University of Oxford, UK
Genetic and Epigenetic Modulators of Monocyte Activation in Health and Disease

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Transcriptional and Epigenetic Regulation in Cancer and Cancer Immunotherapy

Nicole Soranzo, Wellcome Trust Sanger Institute, UK
Human Genetic Variation of Hematological Parameters

Dafni Glinos, Wellcome Trust Sanger Institute, UK
Short Talk: Genetic Effects on Transcriptional Variation of Human T Regulatory Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 3
19:30—22:00
Poster Session 1

Ballroom 3

TUESDAY, JANUARY 30

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Advancing our Understanding of Immune Cell Repertoires
Meeting has ended...abstracts no longer viewable online.
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.

Ballroom 1-2
* Michael Vincent, Pfizer Inc., USA

Aleksandra Walczak, École Normale Supérieure, France
Diversity of Immune Receptor Repertoires

Mark M. Davis, ITI, USA
T-Cell Repertoires and How to Read Them

Coffee Break

Harlan Robins, Fred Hutchinson Cancer Research Center, USA
Reading the Cellular Adaptive Immune System to Diagnose Disease

George Georgiou, University of Texas at Austin, USA
The Human Serological and BCR Antibody Repertoires in Cancer, Autoimmunity or following Vaccination

Nathaniel D. Chu, Massachusetts Institute of Technology, USA
Short Talk: Longitudinal Immunosequencing in Healthy Individuals Reveals Persistent T Cell Receptors Rich in Public Receptors

Scott Nicholas Furlan, Seattle Children's Research Institute, USA
Short Talk: Dissecting the Mechanics of T Cell Alloproliferation

11:15—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

Ballroom 3
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Integrative Analysis, Dynamic Networks and Systems Immunology
Meeting has ended...abstracts no longer viewable online.
In this session we focus on different methodological approaches to build networks and models of systems.

Ballroom 1-2
* Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA

Kasper Lage, Massachusetts General Hospital, USA
Human Gene and Protein Networks Perturbed by Genetics to Identify Therapeutics

Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Talk Title to be Announced

Shai S. Shen-Orr, Technion, Israel
Connect the Dots – An Integrative Cell-Centered View of Immunity

Jiyang Yu, St. Jude Children's Research Hospital, USA
Short Talk: NetBID, a Novel Systems Biology Approach, Identifies Hippo Signaling as a “Hidden” Driver Selectively Programming CD8α+ Dendritic Cell Activity

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 3
19:30—22:00
Poster Session 2

Ballroom 3

WEDNESDAY, JANUARY 31

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Systems Immunology at the Tissue Level
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
* Nicole Soranzo, Wellcome Trust Sanger Institute, UK

Betty Diamond, Feinstein Institute for Medical Research, USA
Deconstructing Lupus Nephritis through a Single Analysis of Immune Cells in the Kidney

Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA
Single Cell Sequencing in Rheumatoid Synovial Tissue

Coffee Break

Carolyn B. Coyne, University of Pittsburgh, USA
Immunology of the Human Placenta

Elham Azizi, Memorial Sloan Kettering Cancer Center, USA
Computational Approaches to Understanding Cellular Heterogeneity in the Tumor-Immune Microenvironment

Zoltan Maliga, Harvard Medical School, USA
Short Talk: Deep Immunophenotyping of Idiopathic and ICI-Induced Skin Disease with Cyclic Immunofluorescence Microscopy

Michelle Miron, Columbia University, USA
Short Talk: Human Lymph Nodes Maintain Resident Memory T Cells with High Proliferative Capacity and Clonal Diversity

11:15—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

Ballroom 3
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Human Immune Response to Infectious Disease
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
* Mark M. Davis, ITI, USA

Bali Pulendran, Stanford University School of Medicine, USA
Microbiome and B Cell Responses

Purvesh Khatri, Stanford University, USA
Adventures of a "Data Parasite": Translational Medicine using Heterogeneous Public Data

Máté Manczinger, MTA Szegedi Biológiai Kutatóközpont, Hungary
Short Talk: Pathogen Diversity Drives the Evolution of Promiscuous Peptide Binding of Human MHC-II Alleles

Susanna S. Ng, QIMR Berghofer Medical Research Institute, Australia
Short Talk: Identifying Novel Immune Checkpoint Molecules that can be Targeted to Improve CD4+ T Helper Cell Function during Chronic Infection

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 3
19:30—22:00
Poster Session 3

Ballroom 3

THURSDAY, FEBRUARY 1

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:30
Immuno-Oncology from Basic Science to Clinical Practice
Meeting has ended...abstracts no longer viewable online.
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.

Ballroom 1-2
* Kasper Lage, Massachusetts General Hospital, USA

Shannon J. Turley, Genentech, Inc., USA
Leukocyte Function and Positioning in Diverse Stromal Niches

Alexandra Snyder, Adaptive Biotechnologies, USA
T Cell Receptor Sequencing (TCR) in Immuno-Oncology: Systemic, Intratumoral and Antigen-Specific Immunity

Coffee Break

Cassian Yee, University of Texas MD Anderson Cancer Center, USA
Terminators: No Fate but What You Make

Wendy Broom, Genocea Biosciences, USA
Neoantigen Identification using ATLAS Across Multiple Tumor Types Highlights Limitations of Prediction Algorithms

Pauline L. Gonnord, INSERM UMR1043, France
Short Talk: High-Dimensional Immunophenotyping of Chronic Lymphocytic Leukemia (CLL) Patients Reveals Remodeling of the CD8+ T Cell Compartment by Tumor Progression and Predicts Need for Therapy

Daniel Wells, Parker Institute for Cancer Immunotherapy, USA
Short Talk: Genetic Mechanisms of Immune Evasion in Colorectal Cancer

Mazlina Ismail, University College London, UK
Short Talk: Characterising the T Cell Receptor Repertoire of Patients with Non-small-cell Lung Cancer (NSCLC) within the Lung TRACERx Study

11:30—17:00
On Own for Lunch

14:30—16:30
Workshop 2: CyTOF Change to Human Immunoprofiling

Ballroom 1-2
* Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA

Petter Brodin, Karolinska Institutet, Sweden
Convergence of Immune Systems in Diverse Newborn Children during the First Months of Life

Jean-Louis Palgen, CEA, France
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Luis Miguel Franco, National Institutes of Health, USA
Immune Regulation by Glucocorticoids Can Be Linked to Cell-Lineage-Specific Transcriptional Responses

Oisin Huhn, University of Cambridge, UK
Characterizing the Architecture of the Decidual Natural Killer Cell Niche using Time of Flight Mass Cytometry

Ainhoa Perez-Diez, NIAID, National Institutes of Health, USA
Antibody Profiling Identifies a Strong and Widespread Auto-Immune Response in Idiopathic CD4 Lymphopenic Patients

Arnon Arazi, Broad Institute, USA
Beyond Clustering: Using scRNA-seq Data to Generate Quantitative, Testable Models of Human Disease

Ning Jenny Jiang, University of Texas at Austin, USA
High-Throughput Detection of T Cell Antigen Reactivity at Single T Cell Level using de novo Generated DNA-Linked MHC Tetramers

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Clinical Immunoprofiling and Patient Stratification
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
* David M. Sansom, University College London Medical School, UK

Holden T. Maecker, Stanford School of Medicine, USA
Comprehensive Immune Profiling and Functional Analysis of Human Aging / Response to Therapy

Sally John, Biogen, USA
A Network Approach to Understanding the Role of the Immune System in Neurodegenerative Disease

Sathya Baarathi Shanthi Ravichandran, Indian Institute of Science, India
Short Talk: Identification of a Robust Blood-Based Biomarker Signature for Chronic Systemic Inflammation through a Meta-Analysis of Disease Networks

Maria Gutierrez-Arcelus, Harvard Medical School, USA
Short Talk: Cis Regulatory Variation Determines Time Dependent Allelic Expression of HLA-DQB1 during T Cell Activation

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 2-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 2-3

FRIDAY, FEBRUARY 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc. Biogen
Bioverativ Therapeutics Merck & Co., Inc.
Theravance Biopharma
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI136444-01

Funding for this conference was made possible (in part) by 1 R13 AI136444-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Pfizer Research Technology Center


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676