Beaver Run Resort Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Myeloid Cells (B7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Myeloid Cells (D2)


Organizer(s) Edward J. Pearce, Florent Ginhoux and Ana-Maria Lennon-Duménil
April 8—12, 2018
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Dec 7, 2017
Abstract Deadline: Jan 9, 2018
Scholarship Deadline: Dec 7, 2017
Discounted Registration Deadline: Feb 7, 2018

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

Summary of Meeting:
This Keystone Symposia conference is the eighth in a series of related Keystone Symposia conferences that have played a pivotal role in emphasizing and focusing myeloid cell research. High-throughput approaches are revealing previously unappreciated complexity in myeloid cell development and function. This ninth meeting focuses on addressing these issues at the basic levels of ontogeny and cellular activation, in the areas of niche specialization, cell/cell interactions, tissue repair, regeneration and development, and infectious and neoplastic disease. The goals of the meeting are to bring together interdisciplinary groups of researchers to attempt to reveal areas of research synergy in a rapidly evolving field, and to generate a vision of critical areas of future research on myeloid cells. The meeting includes a focus on disease that will serve to emphasize the medical relevance of myeloid cell research. Emphasis on the application of cutting-edge immunological approaches in omics, imaging and cell biology makes the conference of general interest to scientists working in these areas of basic and clinical research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 13 in order to fully experience the meeting.

SUNDAY, APRIL 8

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, APRIL 9

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany

Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Development and Function of Dendritic Cell Subsets

09:00—11:30
Ontogeny and Differentiation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Caetano Reis e Sousa, Francis Crick Institute, UK

* Florent Ginhoux, Singapore Immunology Network, Singapore
Human Dendritic Cells: From Development to Functions

Coffee Break

Joachim L. Schultze, LIMES Institute, University of Bonn, Germany
Human Monocytes, Monocyte-Derived Cells, Dendritic Cells and Tissue Macrophages Revisited

Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics

Venetia Bigley, Newcastle University, UK
Short Talk: Differential IRF8 Requirement Defines Two Pathways of Human Dendritic Cell Development in vivo

Lai Guan Ng, Singapore Immunology Network, Singapore
Short Talk: Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking and Effector Functions

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Workshop 1: Infection

Colorado Ballroom
* David L. Sacks, NIAID, National Institutes of Health, USA

* Molly Ingersoll, Institut Pasteur, France

Lu Huang, Cornell University, USA
Different Macrophage Lineages Exhibit Distinct Metabolic States and Support Differential Growth of Mycobacterium tuberculosis in vivo

Livia Lacerda, Institut Pasteur, France
Novel Macrophage Subsets Differentially Impact Bladder Immunity to Uropathogen Infection

Sang Hun Lee, NIAID, National Institutes of Health, USA
Mannose Receptor (MRhi), M2 Dermal Macrophages Mediate Non-Healing Leishmania Major Infection in a TH1 Immune Environment

Rejane Rua, NINDS, National Institutes of Health, USA
Infection and Natural Inflammatory Aging Drive Monocyte Engraftment into the Meninges that Impairs CNS Immunity

Nan Zhang, Washington University in St. Louis, USA
Clotting Initiated by Factor V+ Resident Peritoneal Macrophages Rapidly Limits Systemic Microbial Dissemination and Accounts for the “Macrophage Disappearance Reaction"

Bibo Zhu, Mayo Clinic, USA
Reciprocal Regulation of Lung-Resident Alveolar Macrophage Function and Repopulation by β-Catenin and PPAR-γ Dictates Host Morbidity and Tissue Recovery from Respiratory Viral Infection

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Priming and Tolerance
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA

* Andrey S. Shaw, Genentech, Inc., USA

Martin Guilliams, Ghent University - VIB, Belgium
Transcriptional Control of Macrophage Identity

Caetano Reis e Sousa, Francis Crick Institute, UK
Dendritic Cells as Drivers of Immunity

Jordi C. Ochando, Mount Sinai School of Medicine, USA
Preventing Trained Immunity Promotes Immunological Tolerance

Anders Etzerodt, Aarhus University, Denmark
Short Talk: Tissue-Resident Macrophages in Omentum Play a Key Role in Development of Metastatic Ovarian Cancer

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

TUESDAY, APRIL 10

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
Inflammation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* David L. Sacks, NIAID, National Institutes of Health, USA

* Tim Lämmermann, Max Planck Institute of Immunobiology and Epigenetics, Germany

Andrés Hidalgo, Fundación CNIC, Spain
Rhythms of Neutrophils in Homeostasis

Mariana J. Kaplan, NIAMS, National Institutes of Health, USA
Neutrophils in Autoimmune Diseases

Coffee Break

Mihai G. Netea, Radboud University, Netherlands
Innate Immunity in Sepsis

William C. Gause, Rutgers New Jersey Medical School, USA
Macrophage and Neutrophil Interactions during Pulmonary Inflammation

Andreas Schlitzer, University of Bonn, Germany
Short Talk: Lung-Specific Innate Immune Memory Controls Reactivity of Mononuclear Phagocytes to Acute and Chronic Inflammation

Honami Naora, University of Texas MD Anderson Cancer Center, USA
Short Talk: Tumor-Induced Neutrophil Extracellular Traps Promote Formation of the Pre-Metastatic Niche in Ovarian Cancer

Pierre Guermonprez, Kings College London, UK
Short Talk: Ontogeny of Human Inflammatory Dendritic Cells

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regeneration/Repair/Development
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Gwendalyn J. Randolph, Washington University, USA

* Andrés Hidalgo, Fundación CNIC, Spain

Paul Martin, University of Bristol, UK
Live Imaging Inflammation in Wound Healing and Cancer

Sonia Garel, INSERM, France
Microglia and Neuron Interactions during Development

Limin Shang, Novimmune SA, Switzerland
Selective CD47 Targeting to Harness Macrophage Activity to Control Tumor Growth

Guillaume Dumenil, Institut Pasteur, France
Short Talk: Neisseria Meningitidis Detection by Perivascular Macrophages Fails to Recruit Neutrophils Sufficiently Early to Control Vascular Damages

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

WEDNESDAY, APRIL 11

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Activation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mihai G. Netea, Radboud University, Netherlands

* Ana-Maria Lennon-Duménil, Curie Institute, France

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Repurposed for Cytokines in Macrophages

Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Control of Alternative Macrophage Activation

Coffee Break

Ana-Maria Lennon-Duménil, Curie Institute, France
A Unique Population of Intra-Epithelial Dendritic Cells Restricted to the Upper Region of the Small Intestine

Rab K. Prinjha, GlaxoSmithKline, UK
Drugging Transcription: Progress and Potential for Treating Human Immune Dysfunction

Philippe J. Benaroch, Institut Curie, INSERM, France
Short Talk: Siglec-1 Expression by Human Dendritic Cell Precursors Enables HIV-1 Replication and Dissemination to CD4+ T Cells

Brian T. Edelson, Washington University School of Medicine, USA
Short Talk: The Transcription Factor Bhlhe40 Regulates Large Peritoneal Macrophages and Type 2 Immunity

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Workshop 2: Cancer

Colorado Ballroom
* Jie Sun, Mayo Clinic, USA

Faezzah Baharom, National Institutes of Health, USA
Targeting Dendritic Cells and Monocytes with a Nanoparticle Neoantigen-TLR7/8 Agonist Vaccine Induces Anti-Tumor CD8 T Cell Immunity

Katherine Brempelis, Seattle Children's Research Institute, USA
Genetically Engineered Macrophages as an Immunotherapy for Solid Tumors

Mytrang Do, Weill Cornell Medical College, USA
mTORC1- Dependent Regulation of Macrophage Response in Cancer

Hiroki Ishii, NCI, National Institutes of Health, USA
miR-130a and -145 Reprogram Myeloid-Derived Suppressor Cells and Inhibit Tumor Metastasis through Improved Anti-Tumor Immunity

Sarah E. Corcoran, Trinity College Dublin, Ireland
The Small Molecule NLRP3 Inhibitor MCC950 Potently Inhibits the Production of the Mature Forms of Caspase 1, IL-1b and IL-18 ex Vivo in PBMCs from Familial Cold Autoinflammatory Syndrome (FCAS) Patients

Karen Olivia Dixon, Harvard Medical School/Brigham and Women's Hospital, USA
The Co-Inhibitory Molecule TIGIT Contributes to Suppressor Function of Dendritic Cells

Hai Huang, University of Pittsburgh, USA
Neutrophil Extracellular Traps Promote Inflammation and Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cancer
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Romina S. Goldszmid, NCI, National Institutes of Health, USA
Microbiota: Key Modulator of the Tumor Microenvironment

Hélène Salmon, Icahn School of Medicine at Mount Sinai, USA
Modulating the Myeloid and Stromal Cell Compartments to Promote Anti-Tumor Immunity

Matthew F. Krummel, University of California, San Francisco, USA
Imaging and Manipulating Myeloid Biology in Cancer

Julie Helft, Institut Curie, France
Short Talk: High-Dimensional Analysis of the Myeloid Cell Landscape in Human Breast Cancer Metastatic Lymph Nodes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

THURSDAY, APRIL 12

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Niche Specialization
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Paul Martin, University of Bristol, UK

* Florent Ginhoux, Singapore Immunology Network, Singapore

Alison Clare Lloyd, University College London, UK
The Role of Macrophages in Peripheral Nerve Homeostasis and Regeneration

Gwendalyn J. Randolph, Washington University, USA
Serosal Macrophages

Coffee Break

Steffen Jung, Weizmann Institute of Science, Israel
Studying Microglia and BM Graft-derived CNS Macrophages - Transcriptomes, Epigenomes and Responsiveness to Challenge

Daniel R. Saban, Duke University School of Medicine, USA
Short Talk: A Novel Microglia-Restricted Microniche in the Retina Is Associated with Neuroprotection

Sebastiaan De Schepper, KU Leuven, Belgium
Short Talk: Self-Maintaining Embryonic Gut Macrophages Are Essential for Intestinal Homeostasis

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 3: Ontogeny/Different Tissue Populations

Colorado Ballroom
* Slava Epelman, University of Toronto, Canada

* Andreas Schlitzer, University of Bonn, Germany

Anna E. Beaudin, University of California, Merced, USA
Regulation of Tissue-Resident Macrophage Development by IL7R

Sarah A. Dick, University Health Network, Canada
Using Single Cell Genomics and Genetic Fate Mapping to Define Cardiac Macrophage Heterogeneity and Cardioprotective Functions

Laufey Geirsdottir, Uniklinik Freiburg, Germany
What Makes a Microglia? Comparing Relatives in the Molecular Age

Rebecca Gentek, Centre d'Immunologie de Marseille-Luminy CIML, France
Tissue-Resident Mast Cells Are of Dual Hematopoietic Origin

Chang Liu, NHLBI, National Institutes of Health, USA
Distribution and Functions of Embryonic Microglial Cells in the Immunoprivileged Central Nervous System

Zhaoyuan Liu, Shanghai Jiao Tong University, China
A Universal Fate Mapper Mouse Model of Blood-Circulating Monocytes

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Myeloid Crosstalk
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Steffen Jung, Weizmann Institute of Science, Israel

* William C. Gause, Rutgers New Jersey Medical School, USA

Venizelos Papayannopoulos, Francis Crick Institute, UK
Neutrophils in the Regulation of Inflammation

Daniel Robert Engel, Institute of Experimental Immunology and Imaging, Germany
Crosstalk of Myeloid Cells at Mucosal Sites

Tim Lämmermann, Max Planck Institute of Immunobiology and Epigenetics, Germany
Myeloid Cell Dynamics at Local Sites of Inflammation, Infection and Anaphylaxis

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Breckenridge Ballroom

FRIDAY, APRIL 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI138575-01

Funding for this conference was made possible (in part) by 1R13AI138575-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



NovImmune SA


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676