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This meeting took place in 2018



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The Resolution of Inflammation in Health and Disease (C6)


Organizer(s) Catherine Godson, Ira Tabas and Mauro Perretti
March 24—28, 2018
Royal Dublin Society • Dublin, Ireland
Discounted Abstract Deadline: Nov 29, 2017
Abstract Deadline: Dec 21, 2017
Scholarship Deadline: Nov 29, 2017
Discounted Registration Deadline: Jan 18, 2018

Organized in Collaboration with Science Foundation Ireland
Sponsored by Gilead Sciences, Inc.
This activity was supported by an educational grant from Celgene Corporation.

Summary of Meeting:
Inflammation and its resolution are critical to effective host defense and tissue homeostasis. There is a steady increase in the recognition that the effective resolution of inflammation is dynamically regulated through cellular responses to endogenously generated mediators. Ineffective resolution of inflammatory responses likely contributes to the pathogenesis of numerous prevalent conditions including atherosclerosis, arthritis and diabetes. Unresolved chronic inflammation may lead to fibrosis and eventual organ failure. Whereas anti-inflammatory therapeutic approaches are conventional, a growing consensus based on experimental data suggests that an alternative approach may be to mimic agonism of resolution. The aim of this meeting is to enhance our understanding of the molecular mechanisms which underpin the effective resolution of inflammation and how these may fail in aging and disease. Specifically, it seeks to: 1) Encourage dialog between those working in areas where the potential of mimicry of resolution of inflammation might play an under-appreciated role; 2) Consolidate data from diverse mediators that promote resolution; and 3) Contribute to the education and training of graduate students, fellows and faculty. These discussions will provide a multidisciplinary community with insight into physiologic processes underpinning resolution and potential mimicry of such processes for therapeutic gain in pathological conditions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Saturday, March 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, March 28 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Thursday, March 29 in order to fully experience the meeting.

SATURDAY, MARCH 24

16:00—20:00
Arrival and Registration

Hall 4
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Hall 4

SUNDAY, MARCH 25

08:00—08:30
Poster Setup

Hall 4
08:30—17:00
Poster Viewing

Hall 4
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Catherine Godson, University College Dublin, Ireland

* Alberto Mantovani, Humanitas University, Italy

Charles N. Serhan, Brigham and Women's Hospital, USA
Pro-Resolving Lipid Mediators & Mechanisms in the Resolution of Inflammation

09:30—12:00
Fundamentals of Inflammation Biology – Cells, Mediators and Mechanisms in the Resolution of Inflammation I
Meeting has ended...abstracts no longer viewable online.
Mediators, targets, cells, macrophages, ILCs, T cell plasticity, specialized pro-resolving mediators, proteins and peptides, hypoxia, cannabinoids, efferocytosis, prostanoids, PPARs, A20, SOCS, etc.

Concert Hall
* Catherine Godson, University College Dublin, Ireland

* Alberto Mantovani, Humanitas University, Italy

Derek W. Gilroy, University College London, UK
Susceptibility to Infection or Autoimmunity – It All Depends on How Inflammation Resolves

Ioannis Kourtzelis, University of Dresden, Germany
Short Talk: The Endogenous Homeostatic Factor Del-1 Contributes to Resolution of Inflammation

Coffee Break

Daniele Piomelli, University of California, Irvine, USA
NAAA-Regulated Lipid Amide Signaling as a Point of Control in Inflammation

Charles A. Parkos, University of Michigan, USA
Short Talk: Epithelial Expression of CD47 Plays a Crucial Role in Intestinal Mucosal Wound Healing

Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK
Differential Regulation of Leukocyte Function by the HIF/Hydroxylase Pathway

12:00—12:45
Lunch

Hall 4
12:00—14:30
Poster Session 1

Hall 4
15:00—16:30
Workshop 1: Resolvomics: Potential and Pitfalls

Concert Hall
* Derek W. Gilroy, University College London, UK

* Bruce D. Levy, Brigham and Women's Hospital, USA

Amiram Ariel, University of Haifa, Israel
IFNbeta is a Novel Effector Cytokine in Resolving Inflammation

Fiona C. McGillicuddy, Conway Institute, University College Dublin, Ireland
Metabolic High Density Lipoprotein Particles in Human Obesity – A Novel Tool for the Measurement of Metabolic Inflammation?

Koen Schepers, Leiden University Medical Center, Netherlands
Mapping the Essential Roles of Amino Acid and Lipid Metabolism in Mesenchymal Stromal Cell-Mediated Immunomodulation

Daniel Irimia, Massachusetts General Hospital, USA
How to Cool a Chain-Reaction: LXA4 Controls Neutrophil Swarming

Astrid S. Kahnt, Goethe University, Germany
SPM Biosynthesis in Human Leukocytes – Who’s Involved?

16:30—17:00
Coffee Available

Hall 4
17:00—19:00
Fundamentals of Inflammation Biology – Cells, Mediators and Mechanisms in the Resolution of Inflammation II
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Mauro Perretti, Queen Mary University of London, UK

* Lina Hsiu Kim Lim, National University of Singapore, Singapore

Alberto Mantovani, Humanitas University, Italy
Macrophage Plasticity and Tuning of Innate Immunity and Inflammation

Marc Peters-Golden, University of Michigan, USA
Vesicular SOCS as a Vector of Macrophage to Epithelial Cell Crosstalk at the Respiratory Surface

Douglas Brubaker, Massachusetts Institute of Technology, USA
Short Talk: Systems Biology Approaches To Precision Medicine in Inflammatory Bowel Disease

Carla V. Rothlin, Yale University, USA
TAM Receptor Signaling in Resolution of Inflammation

19:00
On Own for Dinner


MONDAY, MARCH 26

08:30—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Ira Tabas, Columbia University, USA

* Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK

Christopher K. Glass, University of California, San Diego, USA
Nature and Nurture of Tissue-Resident Macrophages

09:15—11:45
Diseases of Dysregulated Resolution and Repair
Meeting has ended...abstracts no longer viewable online.
Complex pathologies = failed resolution? Focus on atherosclerosis, cancer, arthritis.

Concert Hall
* Ira Tabas, Columbia University, USA

* Sarah R. Walmsley, University of Edinburgh, Queen's Medical Research Institute, UK

Lina Hsiu Kim Lim, National University of Singapore, Singapore
Annexins in Breast Cancer: Regulation of Inflammation and Metastasis

Joan Claria, University of Barcelona, Spain
Short Talk: Specialized Pro-Resolving Mediators (SPM) and Resolution of Inflammation in Obese Adipose Tissue and Liver

Coffee Break

Bruce Cronstein, New York University, USA
What Goes Around Comes Around. Adenosine, A Retaliatory Metabolite, Dampens Inflammation and Promotes Wound Healing

Edward A. Fisher, New York University School of Medicine, USA
Short Talk: Inflammatory Monocytes Drive the Resolution of Atherosclerosis in a Plaque Regression Mouse Model by Becoming M2 Macrophages with Distinct Molecular Features

Gabrielle Fredman, Albany Medical Center, USA
Dysregulation of Resolution Pathways in Chronic Inflammatory Disease

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Hall 4
13:00—22:00
Poster Viewing

Hall 4
15:00—16:30
Workshop 2: Experimental Models of Resolution

Concert Hall
* Matthew Spite, Harvard Medical School and Brigham and Women's Hospital, USA

* Gabrielle Fredman, Albany Medical Center, USA

Audrey Bernut, University of Sheffield, UK
Balancing the Immune Response in Cystic Fibrosis: Using Zebrafish Models of Inflammation to Uncover New Therapeutic Approaches

Steven Bozinovski, RMIT University, Australia
Aspirin-Triggered Resolvin D1 Reduces Pneumococcal Lung Burden in a Viral and Bacterial Co-Infection Model

Annie Curtis, Royal College of Surgeons in Ireland, Ireland
Loss of the Molecular Clock in Myeloid Cells Exacerbates T Cell-Mediated CNS Autoimmune Disease

Stephanie A. Legere, Dalhousie University, Canada
A Potential Role for Human Mast Cells in the Resolution of Cardiac Inflammation

Viktoria Lyngstadaas, Harvard Medical School, USA
The Pro-Resolving Mediator Annexin A1 Regulates MUC5AC Secretion in Cultured Goblet Cells, Suggesting a New Use in Inflammatory Conjunctival Diseases

16:30—17:00
Coffee Available

Hall 4
17:00—19:00
Diabesity and the Resolution of Inflammation
Meeting has ended...abstracts no longer viewable online.
Obesity and type 2 diabetes.

Concert Hall
* Joan Claria, University of Barcelona, Spain

* Eoin P. Brennan, Conway Institute, Ireland

Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Journal of Lipid Research Lectureship: Metaflammation, Organelle Function and Metabolic Homeostasis

Yun Sok Lee, University of California, San Diego, USA
Tissue Hypoxia in Metaflammation and Type 2 Diabetes

Brian Sansbury, Harvard Medical School, USA
Short Talk: Resolvin D1 Promotes Revascularization during Limb Ischemia via its Receptor, ALX/FPR2

Catherine Godson, University College Dublin, Ireland
Lipoxins: Resolving Inflammation, Suppressing Diabetic Complications

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Hall 4
19:30—22:00
Poster Session 2

Hall 4

TUESDAY, MARCH 27

08:30—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Edward A. Fisher, New York University School of Medicine, USA

* Charles A. Parkos, University of Michigan, USA

Lalita Ramakrishnan, University of Cambridge, UK
Host Genotype Dictates Inflammation, Resolution and Repair

09:15—11:45
Regulation of Defense, Resolution and Repair
Meeting has ended...abstracts no longer viewable online.
Imprinting/Genetics, GWAS, T cell plasticity, transcriptional networks, systems biology of resolution.

Concert Hall
* Edward A. Fisher, New York University School of Medicine, USA

* Charles A. Parkos, University of Michigan, USA

Ira Tabas, Columbia University, USA
The Interplay Between Efferocytosis and Inflammation Resolution

Michelle Amantéa Sugimoto, Universidade Federal de Minas Gerais, Brazil and Queen Mary University of London, UK
Short Talk: Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Efferocytosis and Macrophage Reprogramming

Coffee Break

Muredach P. Reilly, Columbia University, USA
Genomic Discoveries in Metainflammation

Matt DeBerge, Northwestern University, USA
Short Talk: Divergence of TAM Receptor Tyrosine Kinase Control of Inflammation Resolution and Repair after Heart Attack

Maksim Plikus, University of California, Irvine, USA
Reactivating Embryonic-Like Regeneration Programs in Adult Skin Wounds

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Hall 4
13:00—22:00
Poster Viewing

Hall 4
15:00—16:30
Workshop 3: Nano Technologies and Targeting Receptors to Resolve Inflammation

Concert Hall
* Nan Chiang, Harvard Medical School, USA

Louise M. Topping, Queen Mary University of London, UK
Targeting Neutrophil Microvesicles to Damaged Cartilage Using Antibodies to Post-Translationally Modified Collagen II

Eva Koziolova, Institute of Macromolecular Chemistry, Czech Republic
Polymer-Based Drug Delivery Systems for Targeted Therapy of Inflammatory Diseases – Their in vivo Biodistribution in Mice with Acute Arthritis

Simon Rauber, Friedrich-Alexander University Erlangen-Nürnberg, Germany
IL-9-Producing Type 2 Innate Lymphoid Cells – Key Players that Orchestrate Resolution of Chronic Inflammation in Arthritis

Miguel Quiros, University of Michigan, USA
Specialized Pro-Resolving Lipid Mediator Resolvin E1 Promotes Intestinal Mucosal Wound Repair

Takehiko Yokomizo, Juntendo University School of Medicine, Japan
12-Hydroxyheptadecatrienoic Acid Accelerates Epithelial Wound Healing through Leukotriene B4 Receptor 2, BLT2

16:30—17:00
Coffee Available

Hall 4
17:00—19:15
Infection
Meeting has ended...abstracts no longer viewable online.
Bacterial infection, sepsis, viral infection, parasites, barrier function.

Concert Hall
* Nathalie Vergnolle, INSERM UMR-1220, France

* Charles N. Serhan, Brigham and Women's Hospital, USA

Bruce D. Levy, Brigham and Women's Hospital, USA
Specialized Pro-Resolving Mediators: Endogenous Regulators of Infection

Asma Nusrat, University of Michigan, USA
Intestinal Mucosal Barrier Repair Is Orchestrated by Pro-Repair Mediators Released by Epithelial and Immune Cells at Sites of Injury

Aoife Keogh, Royal College of Surgeons in Ireland, Ireland
Short Talk: MSC-Monocyte Interactions in Sepsis

Mauro Martins Teixeira, Universidade Federal de Minas Gerais, Brazil
The Impact of Resoluton Pathways in Acute Infections – Annexin-a1 and Dengue

Prabir Ray, University of Pittsburgh, USA
Short Talk: The Mito-DAMP Cardiolipin Suppresses Resolution of Bacterial Pneumonia

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Hall 4
19:30—22:00
Poster Session 3

Hall 4

WEDNESDAY, MARCH 28

08:30—11:45
Resolution and Repair or Fibrosis?
Meeting has ended...abstracts no longer viewable online.
Cellular cross-talk and signal integration, failed resolution, epithelial plasticity, TGF-beta super-family, novel targets.

Concert Hall
* Lalita Ramakrishnan, University of Cambridge, UK

* Lucy V. Norling, Queen Mary University of London, UK

Nathalie Vergnolle, INSERM UMR-1220, France
Proteolytic Balance in Mucosal Inflammation and Repair

Robert F. Schwabe, Columbia University, USA
Liver Cancer: A Wound That Does Not Heal

Takayoshi Suganami, Nagoya University, Japan
Short Talk: CD11c+ Resident Macrophages Drive Hepatocyte Death-Triggered Liver Fibrosis in Nonalcoholic Steatohepatitis

Coffee Break

Jörg H.W. Distler, University of Erlangen-Nuremberg, Germany
Targeting Persistent Fibroblast Activation in Fibrotic Diseases

Preethi Vijayaraj, University of California, Los Angeles, USA
Short Talk: Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-Fibrotic Small Molecule

Jesmond Dalli, Queen Mary University of London, UK
Immunoresolvents Promote Tissue Repair and Regeneration

11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Hall 4
17:00—19:00
Therapeutic Innovation in Resolution
Meeting has ended...abstracts no longer viewable online.
Receptor pharmacology, biased agonism, omega-3 derived therapeutics.

Concert Hall
* Daniele Piomelli, University of California, Irvine, USA

* Bruce Cronstein, New York University, USA

Arthur Christopoulos, Monash University, Australia
Harnessing GPCR Allostery and Bias for Novel Drug Targeting

Mauro Perretti, Queen Mary University of London, UK
From Resolution of Inflammation to Resolution Pharmacology: Therapeutic Innovation in Inflammation

Monica de Gaetano, University College Dublin, Ireland
Short Talk: Investigation of the Bioactions of Novel Synthetic Lipoxin Mimetics

Makoto Arita, Keio University, Japan
Genetics and Lipidomics of Omega-3 Polyunsaturated Fatty Acid Biology

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Concert Hall
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Hall 4
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Hall 4

THURSDAY, MARCH 29

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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Keystone Symposia thanks our Sponsors for generously supporting this meeting:

This activity was supported by an educational grant from Celgene Corporation Gilead Sciences, Inc.
Science Foundation Ireland
 

We gratefully acknowledge additional support from these exhibitors at this conference:

Don Whitley Scientific Limited
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI136481-01

Funding for this conference was made possible (in part) by 1 R13 AI136481-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cayman Chemical Company Fáilte Ireland
Journal of Lipid Research Research Diets, Inc.

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