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This meeting took place in 2018



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Novel Aspects of Bone Biology (E3)


Organizer(s) Gerard Karsenty and David T. Scadden
June 13—16, 2018
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Feb 27, 2018
Abstract Deadline: Mar 27, 2018
Scholarship Deadline: Feb 27, 2018
Discounted Registration Deadline: Apr 12, 2018

Supported by the Directors' Fund

Summary of Meeting:
This conference presents recent progress made in two relatively novel areas of skeletal biology not covered by other meetings. The first one is the cross-talk between bone, hematopoiesis and leukemogenesis. The second is the study of the various endocrine functions of bone and how their study impacts on our understanding of multiple degenerative diseases. Meetings of bone biology are traditionally dominated by the need to explain the basis and to propose treatments for the most frequent bone disease: osteoporosis. Aside from this very vivid field, these two other novel aspects of bone biology have developed in the last decade. A shared feature is that they link bone biology to multiple other organs and to other functions besides making bones. This conference showcases the many advances made in these two aspects of skeleton biology and how these developments have enriched our understanding of the pathogenesis of multiple degenerative diseases affecting the bone marrow, energy metabolism or the brain. Because of its very nature, this conference brings together investigators from different fields rarely afforded an opportunity to meet.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Wednesday, June 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, June 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, June 17 in order to fully experience the meeting.

WEDNESDAY, JUNE 13

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

THURSDAY, JUNE 14

07:30—08:30
Breakfast

Primrose
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Christa Maes, KU Leuven, Belgium

Daniel E. Lieberman, Harvard University, USA
An Evolutionary Medical Perspective on Bone Disease

09:30—12:00
The Origin of the Osteoblast
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Christa Maes, KU Leuven, Belgium

Roberta Faccio, Washington University, USA
Bone-Derived Dickkopf-Related Protein 1 (Dkk1) Exerts Immune-Suppressive Effects in Cancer

Coffee Break

Siddhartha Mukherjee, Columbia University Medical Center, USA
Definition of a Post-Natal Osteoblast Stem Cell

Henry M. Kronenberg, Massachusetts General Hospital, USA
Sox9-Expressing Cells Are Progenitors of Osteoblasts, Stromal Cells and Chondrocytes in Mouse Bone

Shawon Debnath, Weill Cornell Medicine, Cornell University, USA
Short Talk: Identification of a Novel Periosteal Stem Cell Population that Mediates Intramembranous Bone Formation

Constance T. Noguchi, NIDDK, National Institutes of Health, USA
Short Talk: Altered Erythropoietin Signaling Disrupts Bone Marrow Stromal Cell Differentiation

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
The Bone Marrow Niche
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Sabina Sangaletti, Fondazione IRCCS Istituto Tumori Milano, Italy

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Defining (and applying) The Bone Marrow Niche

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
The Maintenance of the Adult Skeleton

Paul S. Frenette, Albert Einstein College of Medicine, USA
Neural Regulation of the Aging Bone Marrow Niche

John Chute, University of California, Los Angeles, USA
Bone Marrow Osteolineage Cells Regulate Hematopoietic Regeneration via Secretion of Dkk1

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Primrose
19:30—22:00
Poster Session 1

Primrose

FRIDAY, JUNE 15

07:30—08:30
Breakfast

Primrose
08:30—11:45
The Endocrine Function of the Osteoblast
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Mathieu Ferron, Institut de Recherches Cliniques de Montréal, Canada

Gerard Karsenty, Columbia University Medical Center, USA
Osteocalcin Is Necessary and Sufficient to Mount an Acute Stress Response

Aline Bozec, University of Erlangen, Germany
High-Fat Diet and Microbiota Control the Bone Marrow Niche and Hematopoietic Stem Cell Differentiation

Coffee Break

Seiji Fukumoto, Tokushima University, Japan
The Biology of FGF23

Yihong Wan, University of Texas Southwestern Medical Center, USA
Endocrine and Metabolic Regulation of Osteoclastogenesis

Omar Al Rifai, Clinical Research Institute of Montreal, IRCM, Canada
Short Talk: Proprotein Convertase Furin is a Novel Pleiotropic Regulator of Bone Endocrine Functions

Julian Berger, Columbia University Medical Center, USA
Short Talk: Osteocalcin Signaling in the Adrenal Cortex is Necessary for Steroid Hormones Biosynthesis and Adrenal Gland Growth

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
The Relationship between Bone and Leukemia
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Lev Silberstein, Fred Hutchinson Cancer Research Center, USA

Emmanuelle Passegué, Columbia University, USA
Aging of Stem Cells and Leukemogenesis

Stavroula Kousteni, Columbia University, USA
The Osteoblast as an Inducer of Leukemogenesis

Stéphane J. C. Mancini, INSERM, France
Short Talk: Hematopoietic Stem Cells and Early B Cells Form Specific Interaction Networks with A Unique Peri-Sinusoidal Stromal Cell Niche in the Bone Marrow

Annas Al-Sharea, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Cholinergic Regulation of Bone Marrow Vascular Microenvironment Influences Hematopoietic Stem Cell Mobilization

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Primrose
19:30—22:00
Poster Session 2

Primrose

SATURDAY, JUNE 16

07:30—08:30
Breakfast

Primrose
08:30—11:30
Molecular Genetics of Bone Metastasis
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Patricia Ducy, Columbia University, USA

Yibin Kang, Princeton University, USA
The Role of Bone Stromal Niches in the Seeding, Outgrowth and Treatment Resistance of Bone Metastasis

Theresa A. Guise, Indiana University, USA
Systemic Effects of the Tumor-Bone Microenvironment: Mechanisms and Therapeutic Approaches

Coffee Break

G. David Roodman, Indiana University, USA
The Pathogenesis of Multiple Myeloma

Camilla Engblom, Massachusetts General Hospital, USA
Lung Tumors Talk to Bones and Bones Answer Back

Aaron E. Chiou, Cornell University, USA
Short Talk: Investigating Pre-Metastatic Alterations of Bone Extracellular Matrix

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:45
The Relationship between Bone and the Immune System
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Hiroshi Takayanagi, University of Tokyo, Japan
Interaction between Bone and the Immune System

Rheinallt M. Jones, Emory University, USA
The Influence of the Gut Microbiota on Bone Metabolism: In Pursuit of Mechanisms

Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany
Blood Vessel Growth, Function and Aging in the Skeletal System

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 2

SUNDAY, JUNE 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AR073678-01

Funding for this conference was made possible (in part) by 1R13AR073678-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

The Journal of Rheumatology

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676